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August-2015 Volume 12 Issue 2

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Article

X609, a novel manassantin A derivative, exhibits antitumor activity in MG-63 human osteosarcoma cells in vitro and in vivo

  • Authors:
    • Ji Li
    • Kongbo Zhao
    • Fu Wang
    • Jinfang Cai
    • Zongyu Li
    • Lin Zou
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The Quanzhou Licheng Xingxian Hospital, Quanzhou 362005, P.R. China, Department of Orthopedics, Linyi People's Hospital, Linyi 276000, P.R. China, Department of Orthopedics, Shandong Provincial Hospital, Jinan 250021, P.R. China, Department of Orthopedics, The Jinan Military General Hospital, Jinan 250031, P.R. China
  • Pages: 3115-3120
    |
    Published online on: May 5, 2015
       https://doi.org/10.3892/mmr.2015.3729
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Abstract

Manassantin A has been well-established as an inhibitor of HIF-1. In the present study, a new manasantin A derivative, X609, with decreased stereochemical complexity, rendering it amenable to a simplified synthesis scheme, was synthesized and was found to increase HIF‑1 inhibitory activity. X609 exhibited antiproliferative activity in a broad spectrum of tumor cell lines, via HIF‑1‑dependent mechanisms. X609 may induce apoptosis in MG‑63 cells through activation of the mitochondrial pathway. Oral administration of X609 significantly inhibited the growth of human osteosarcomas implanted into nude mice. In light of the results of the present study, it may be possible to develop X609 for use as a novel antitumor agent, which targets human osteosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Zhao K, Wang F, Cai J, Li Z and Zou L: X609, a novel manassantin A derivative, exhibits antitumor activity in MG-63 human osteosarcoma cells in vitro and in vivo. Mol Med Rep 12: 3115-3120, 2015.
APA
Li, J., Zhao, K., Wang, F., Cai, J., Li, Z., & Zou, L. (2015). X609, a novel manassantin A derivative, exhibits antitumor activity in MG-63 human osteosarcoma cells in vitro and in vivo. Molecular Medicine Reports, 12, 3115-3120. https://doi.org/10.3892/mmr.2015.3729
MLA
Li, J., Zhao, K., Wang, F., Cai, J., Li, Z., Zou, L."X609, a novel manassantin A derivative, exhibits antitumor activity in MG-63 human osteosarcoma cells in vitro and in vivo". Molecular Medicine Reports 12.2 (2015): 3115-3120.
Chicago
Li, J., Zhao, K., Wang, F., Cai, J., Li, Z., Zou, L."X609, a novel manassantin A derivative, exhibits antitumor activity in MG-63 human osteosarcoma cells in vitro and in vivo". Molecular Medicine Reports 12, no. 2 (2015): 3115-3120. https://doi.org/10.3892/mmr.2015.3729
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Zhao K, Wang F, Cai J, Li Z and Zou L: X609, a novel manassantin A derivative, exhibits antitumor activity in MG-63 human osteosarcoma cells in vitro and in vivo. Mol Med Rep 12: 3115-3120, 2015.
APA
Li, J., Zhao, K., Wang, F., Cai, J., Li, Z., & Zou, L. (2015). X609, a novel manassantin A derivative, exhibits antitumor activity in MG-63 human osteosarcoma cells in vitro and in vivo. Molecular Medicine Reports, 12, 3115-3120. https://doi.org/10.3892/mmr.2015.3729
MLA
Li, J., Zhao, K., Wang, F., Cai, J., Li, Z., Zou, L."X609, a novel manassantin A derivative, exhibits antitumor activity in MG-63 human osteosarcoma cells in vitro and in vivo". Molecular Medicine Reports 12.2 (2015): 3115-3120.
Chicago
Li, J., Zhao, K., Wang, F., Cai, J., Li, Z., Zou, L."X609, a novel manassantin A derivative, exhibits antitumor activity in MG-63 human osteosarcoma cells in vitro and in vivo". Molecular Medicine Reports 12, no. 2 (2015): 3115-3120. https://doi.org/10.3892/mmr.2015.3729
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