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Article

Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility

  • Authors:
    • Malgorzata Szczepańska
    • Adrianna Mostowska
    • Przemyslaw Wirstlein
    • Jana Skrzypczak
    • Matthew Misztal
    • Paweł P. Jagodziński
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, Poznań 60‑781, Poland, Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań 60‑781, Poland
  • Pages: 3055-3060
    |
    Published online on: May 6, 2015
       https://doi.org/10.3892/mmr.2015.3733
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Abstract

Data suggests that dopamine receptor DRD2 gene variants may contribute to hyperprolactinemia and that they may be risk factors for endometriosis‑related infertility. The purpose of the present study was to determine whether nucleotide variants of the DRD2 gene may be associated with infertility related to endometriosis. Five DRD2 SNPs, rs1800497, rs6277, rs2283265, rs4245146 and rs4648317, which are located in different blocks of linkage disequilibrium, were studied in 151 cases and 381 controls. No significant differences between DRD2 rs1800497, rs6277, rs2283265, rs4245146 and rs4648317 genotype, allele nor haplotype frequencies were observed in women with endometriosis‑related infertility compared with the control group. The present results did not confirm DRD2 gene variants to be genetic risk factors for endometriosis-related infertility.
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1 

Gregoriou G, Bakas P, Vitoratos N, Papadias K, Goumas K, Chryssicopoulos A and Creatsas G: Evaluation serum prolactin levels in patients with endometriosis and infertility. Gynecol Obstet Invest. 48:48–51. 1999. View Article : Google Scholar

2 

Panidis D, Vavilis D, Rousso D, Panidou E and Kalogeropoulos A: Provocative tests of prolactin before, during and after long-term danazol treatment in patients with endometriosis. Gynecol Endocrinol. 6:19–24. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Wang H, Gorpudolo N and Behr B: The role of prolactin- and endometriosis-associated infertility. Obstet Gynecol Surv. 64:542–547. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Reese J, Binart N, Brown N, Ma WG, Paria BC, Das SK, Kelly PA and Dey SK: Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR. Endocrinology. 141:1872–1881. 2000.PubMed/NCBI

5 

Novella-Maestre E, Carda C, Noguera I, Ruiz-Saurí A, García-Velasco JA, Simón C and Pellicer A: Dopamine agonist administration causes a reduction in endometrial implants through modulation of angiogenesis in experimentally induced endometriosis. Hum Reprod. 24:1025–1035. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Ben-Jonathan N, LaPensee CR and LaPensee EW: What can we learn from rodents about prolactin in humans? Endocr Rev. 29:1–41. 2008. View Article : Google Scholar

7 

Missale C, Nash SR, Robinson SW, Jaber M and Caron MG: Dopamine receptors: From structure to function. Physiol Rev. 78:189–225. 1998.PubMed/NCBI

8 

Nilsson C and Eriksson E: Partial dopamine D2 receptor agonists antagonize prolactin-regulating D2 receptors in a transfected clonal cell line (GH4ZR7). Eur J Pharmacol. 218:205–211. 1992. View Article : Google Scholar : PubMed/NCBI

9 

Calarge CA, Ellingrod VL, Acion L, Miller DD, Moline J, Tansey MJ and Schlechte JA: Variants of the dopamine D2 receptor gene and risperidone-induced hyperprolactinemia in children and adolescents. Pharmacogenet Genomics. 19:373–382. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Hansen KA, Zhang Y, Colver R, Tho SP, Plouffe L Jr and McDonough PG: The dopamine receptor D2 genotype is associated with hyperprolactinemia. Fertil Steril. 84:711–718. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Bilibio JP, Matte U, de Conto E, Genro VK, Souza CA and Cunha-Filho JS: Dopamine receptor D2 genotype (3438) is associated with moderate/severe endometriosis in infertile women in Brazil. Fertil Steril. 99:1340–1345. 2013. View Article : Google Scholar

12 

Canis M, Donnez JG, Guzick DS, Halme JK, Rock JA, Schenken RS and Vernon MW: Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 67:817–821. 1997. View Article : Google Scholar

13 

Sasieni PD: From genotypes to genes: Doubling the sample size. Biometrics. 53:1253–1261. 1997. View Article : Google Scholar

14 

Comings DE and Blum K: Reward deficiency syndrome: Genetic aspects of behavioral disorders. Prog Brain Res. 126:325–341. 2000.PubMed/NCBI

15 

Noble EP: D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet B Neuropsychiatr Genet. 116B:103–125. 2003. View Article : Google Scholar

16 

Caccavelli L, Cussac D, Pellegrini I, Audinot V, Jaquet P and Enjalbert A: D2 dopaminergic receptors: Normal and abnormal transduction mechanisms. Horm Res. 38:78–83. 1992. View Article : Google Scholar : PubMed/NCBI

17 

Thompson J, Thomas N, Singleton A, Piggott M, Lloyd S, Perry EK, Morris CM, Perry RH, Ferrier IN and Court JA: D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: Reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics. 7:479–484. 1997. View Article : Google Scholar

18 

Noble EP, Blum K, Ritchie T, Montgomery A and Sheridan PJ: Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry. 48:648–654. 1991. View Article : Google Scholar : PubMed/NCBI

19 

Young RM, Lawford BR, Barnes M, Burton SC, Ritchie T, Ward WK and Noble EP: Prolactin levels in antipsychotic treatment of patients with schizophrenia carrying the DRD2*A1 allele. Br J Psychiatry. 185:147–151. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Mihara K, Suzuki A, Kondo T, Yasui-Furukori N, Ono S, Otani K, Kaneko S and Inoue Y: Relationship between Taq1 A dopamine D2 receptor (DRD2) polymorphism and prolactin response to bromperidol. Am J Med Genet. 105:271–274. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Aklillu E, Kalow W, Endrenyi L, Harper P, Miura J and Ozdemir V: CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine. Pharmacogenet Genomics. 17:989–993. 2007. View Article : Google Scholar : PubMed/NCBI

22 

López-Rodríguez R, Román M, Novalbos J, Pelegrina ML, Ochoa D and Abad-Santos F: DRD2 Taq1A polymorphism modulates prolactin secretion induced by atypical antipsy-chotics in healthy volunteers. J Clin Psychopharmacol. 31:555–562. 2011. View Article : Google Scholar

23 

Houston JP, Fijal B, Heinloth AN and Adams DH: Genetic associations of prolactin increase in olanzapine/fluoxetine combination-treated patients. Psychiatry Res. 175:171–172. 2010. View Article : Google Scholar

24 

Houston J, Dharia S, Bishop JR, Ellingrod VL, Fijal B, Jacobson JG and Hoffmann VP: Association of DRD2 and ANKK1 polymorphisms with prolactin increase in olanzapine-treated women. Psychiatry Res. 187:74–79. 2011. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Szczepańska M, Mostowska A, Wirstlein P, Skrzypczak J, Misztal M and Jagodziński PP: Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility. Mol Med Rep 12: 3055-3060, 2015.
APA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Misztal, M., & Jagodziński, P.P. (2015). Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility. Molecular Medicine Reports, 12, 3055-3060. https://doi.org/10.3892/mmr.2015.3733
MLA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Misztal, M., Jagodziński, P. P."Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility". Molecular Medicine Reports 12.2 (2015): 3055-3060.
Chicago
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Misztal, M., Jagodziński, P. P."Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility". Molecular Medicine Reports 12, no. 2 (2015): 3055-3060. https://doi.org/10.3892/mmr.2015.3733
Copy and paste a formatted citation
x
Spandidos Publications style
Szczepańska M, Mostowska A, Wirstlein P, Skrzypczak J, Misztal M and Jagodziński PP: Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility. Mol Med Rep 12: 3055-3060, 2015.
APA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Misztal, M., & Jagodziński, P.P. (2015). Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility. Molecular Medicine Reports, 12, 3055-3060. https://doi.org/10.3892/mmr.2015.3733
MLA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Misztal, M., Jagodziński, P. P."Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility". Molecular Medicine Reports 12.2 (2015): 3055-3060.
Chicago
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Misztal, M., Jagodziński, P. P."Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility". Molecular Medicine Reports 12, no. 2 (2015): 3055-3060. https://doi.org/10.3892/mmr.2015.3733
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