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Article

Protective effects of gallic acid against spinal cord injury‑induced oxidative stress

  • Authors:
    • Yong Hong Yang
    • Zao Wang
    • Jie Zheng
    • Ran Wang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The 117th Hospital of People's Liberation Army, Hangzhou, Zhejiang 310013, P.R. China
  • Pages: 3017-3024
    |
    Published online on: May 6, 2015
       https://doi.org/10.3892/mmr.2015.3738
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Abstract

The present study aimed to investigate the role of gallic acid in oxidative stress induced during spinal cord injury (SCI). In order to measure oxidative stress, the levels of lipid peroxide, protein carbonyl, reactive oxygen species and nitrates/nitrites were determined. In addition, the antioxidant status during SCI injury and the protective role of gallic acid were investigated by determining glutathione levels as well as the activities of catalase, superoxide dismutase, glutathione peroxidase and glutathione‑S‑transferase. Adenosine triphophatase (ATPase) enzyme activities were determined to evaluate the role of gallic acid in SCI‑induced deregulation of the activity of enzymes involved in ion homeostasis. The levels of inflammatory markers such as nuclear factor (NF)‑κB and cycloxygenase (COX)‑2 were determined by western blot analysis. Treatment with gallic acid was observed to significantly mitigate SCI‑induced oxidative stress and the inflammatory response by reducing the oxidative stress, decreasing the expression of NF‑κB and COX‑2 as well as increasing the antioxidant status of cells. In addition, gallic acid modulated the activity of ATPase enzymes. Thus the present study indicated that gallic acid may have a role as a potent antioxidant and anti‑inflammatory agent against SCI.
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View References

1 

Amar AP and Levy ML: Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury. Neurosurgery. 44:1027–1039. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Hall ED: The role of oxygen radicals in traumatic injury: clinical implications. J Emerg Med. 11(Suppl 1): 31–36. 1993.PubMed/NCBI

3 

Hall ED: Lipid antioxidants in acute central nervous system injury. Ann Emerg Med. 22:1022–1027. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Hall ED: Antioxidant therapies for acute spinal cord injury. Neurotherapeutics. 8:152–167. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Li L, Ng TB, Gao W, Li W, Fu M, Niu SM, Zhao L, Chen RR and Liu F: Antioxidant activity of gallic acid from rose flowers in senescence accelerated mice. Life Sci. 77:230–240. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Ng TB, He JS, Niu SM, Zhao L, Pi ZF, Shao W and Liu F: A gallic acid derivative and polysaccharides with antioxidative activity from rose (Rosa rugosa) flowers. J Pharm Pharmacol. 56:537–545. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Giftson JS, Jayanthi S and Nalini N: Chemopreventive efficacy of gallic acid, an antioxidant and anticarcinogenic polyphenol, against 1,2-dimethyl hydrazine induced rat colon carcinogenesis. Invest New Drugs. 28:251–259. 2010. View Article : Google Scholar

8 

Kroes BH, van den Berg AJ, Quarles van Ufford HC, van Dijk H and Labadie RP: Anti-inflammatory activity of gallic acid. Planta Med. 58:499–504. 1992. View Article : Google Scholar : PubMed/NCBI

9 

Pellegrina CD, Padovani G, Mainente F, Zoccatelli G, Bissoli G, Mosconi S, Veneri G, Peruffo A, Andrighetto G, Rizzi C and Chignola R: Anti-tumour potential of a gallic acid-containing phenolic fraction from Oenothera biennis. Cancer Lett. 226:17–25. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Hsu CL, Lo WH and Yen GC: Gallic acid induces apoptosis in 3T3-1 pre-adipocytes via a Fas- and mitochondrial-mediated pathway. J Agric Food Chem. 55:7359–7365. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Inoue M, Suzuki R, Sakaguchi N, Li Z, Takeda T, Ogihara Y, Jiang BY and Chen Y: Selective induction of cell death in cancer cells by gallic acid. Biol Pharm Bull. 18:1526–1530. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Patel SS and Goyal RK: Cardioprotective effects of gallic acid in diabetes-induced myocardial dysfunction in rats. Pharmacognosy Res. 3:239–245. 2011. View Article : Google Scholar

13 

Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem. 193:265–275. 1951.PubMed/NCBI

14 

Erel O: A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 37:112–119. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Erel O: A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 38:1103–1111. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, Ahn BW, Shaltiel S and Stantman ER: Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186:464–478. 1990.PubMed/NCBI

17 

Esterbauer H and Cheeseman KH: Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol. 186:407–421. 1990.PubMed/NCBI

18 

Hashimoto M, Tanabe Y, Fujii Y, Kikuta T, Shibata H and Shido O: Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats. J Nutr. 135:549–555. 2005.PubMed/NCBI

19 

Sun Y, Oberley LW and Li Y: A simple method for clinical assay of superoxide dismutase. Clin Chem. 34:497–500. 1988.PubMed/NCBI

20 

Aebi H: Catalase. Methods of Enzymatic Analysis. Bergmeyer U: Academic Press; New York: pp. 673–677. 1974

21 

Habig WH, Pabst MJ and Jakoby WB: Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 249:7130–7139. 1974.PubMed/NCBI

22 

Paglia DE and Valentine WN: Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med. 70:158–169. 1967.PubMed/NCBI

23 

Bonting SL: Sodium-potassium activated adenosine triphosphatase and cation transport. Membranes and Ion Transport. Bittar EE: Wiley-Interscience; London: pp. 257–263. 1970

24 

Ohnishi T, Suzuki T, Suzuki Y and Ozawa K: A comparative study of plasma membrane Mg2+ -ATPase activities in normal, regenerating and malignant cells. Biochim Biophys Acta. 684:67–74. 1982. View Article : Google Scholar : PubMed/NCBI

25 

Hjertén S and Pan H: Purification and characterization of two forms of a low-affinity Ca2+ -ATPase from erythrocyte membranes. Biochim Biophys Acta. 728:281–288. 1983. View Article : Google Scholar

26 

Towbin H, Staehelin T and Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA. 76:4350–4354. 1979. View Article : Google Scholar : PubMed/NCBI

27 

Hall ED and Braughler JM: Central nervous system trauma and stroke. II Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radic Biol Med. 6:303–313. 1989. View Article : Google Scholar

28 

Tator CH and Fehlings MG: Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg. 75:15–26. 1991. View Article : Google Scholar : PubMed/NCBI

29 

Faden AI: Therapeutic approaches to spinal cord injury. Adv Neurol. 72:377–386. 1997.PubMed/NCBI

30 

Faden AI and Salzman S: Pharmacological strategies in CNS trauma. Trends Pharmacol Sci. 13:29–35. 1992. View Article : Google Scholar : PubMed/NCBI

31 

Hall ED and Braughler JM: Free radicals in CNS injury. Res Publ Assoc Res Nerv Ment Dis. 71:81–105. 1993.PubMed/NCBI

32 

Koc RK, Akdemir H, Karakücük EI, Oktem IS and Menkü A: Effect of methylprednisolone, tirilazad mesylate and vitamin E on lipid peroxidation after experimental spinal cord injury. Spinal Cord. 37:29–32. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Halliwell B and Gutteridge JM: Oxidative stress. Free Radicals in Biology and Medicine. 3rd. Oxford University Press; New York: pp. 246–350. 1999

34 

Greenberg ME, Li XM, Gugiu BG, Gu X, Qin J, Salomon RG and Hazen SL: The lipid Whisker model of the structure of oxidized cell membranes. J Biol Chem. 283:2385–2396. 2008. View Article : Google Scholar

35 

West JD and Marnett LJ: Endogenous reactive intermediates as modulators of cell signaling and cell death. Chem Res Toxicol. 19:173–194. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Christie SD, Comeau B, Myers T, Sadi D, Purdy M and Mendez I: Duration of lipid peroxidation after acute spinal cord injury in rats and the effect of methylprednisolone. Neurosurg Focus. 25:E52008. View Article : Google Scholar : PubMed/NCBI

37 

Diaz-Ruiz A, Rios C, Duarte I, Correa D, Guizar-Sahagun G, Grijalva I, Madrazo I and Ibarra A: Lipid peroxidation inhibition in spinal cord injury: cyclosporin-A vs. methylprednisolone. Neuroreport. 11:1765–1767. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Price A, Lucas PW and Lea PJ: Age dependent damage and glutathione metabolism in ozone fumigated barley: a leaf section approach. J Exp Bot. 41:1309–1317. 1990. View Article : Google Scholar

39 

Kim KT, Kim MJ, Cho DC, Park SH, Hwang JH, Sung JK, Cho HJ and Jeon Y: The neuroprotective effect of treatment with curcumin in acute spinal cord injury: laboratory investigation. Neurol Med Chir (Tokyo). 54:387–394. 2014. View Article : Google Scholar

40 

Khalatbary AR and Ahmadvand H: Neuroprotective effect of oleuropein following spinal cord injury in rats. Neurol Res. 34:44–51. 2012. View Article : Google Scholar

41 

Nabavi SF, Habtemariam S, Jafari M, Sureda A and Nabavi SM: Protective role of gallic acid on sodium fluoride induced oxidative stress in rat brain. Bull Environ Contam Toxicol. 89:73–77. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Ramkumar K, Vijayakumar R, Vanitha P, Suganya N, Manjula C, Rajaguru P, Sivasubramanian S and Gunasekaran P: Protective effect of gallic acid on alloxan-induced oxidative stress and osmotic fragility in rats. Hum Exp Toxicol. 33:638–649. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Mansouri MT, Farbood Y, Sameri MJ, Sarkaki A, Naghizadeh B and Rafeirad M: Neuroprotective effects of oral gallic acid against oxidative stress induced by 6-hydroxydopamine in rats. Food Chem. 138:1028–1033. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Kurtoglu T, Basoglu H, Ozkisacik EA, Cetin NK, Tataroglu C, Yenisey C and Discigil B: Effects of cilostazol on oxidative stress, systemic cytokine release, and spinal cord injury in a rat model of transient aortic occlusion. Ann Vasc Surg. 28:479–488. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Carroll JE, Hess DC, Howard EF and Hill WD: Is nuclear factor-kappaB a good treatment target in brain ischemia/reperfusion injury? Neuroreport. 11:R1–4. 2000.PubMed/NCBI

46 

Maihöfner C, Schlötzer-Schrehardt U, Gühring H, Zeilhofer HU, Naumann GO, Pahl A, Mardin C, Tamm ER and Brune K: Expression of cyclooxygenase-1 and -2 in normal and glauco-matous human eyes. Invest Ophthalmol Vis Sci. 42:2616–2624. 2001.

47 

Yamamoto T and Nozaki-Taguchi N: Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor and NS-398, a COX-2 selective inhibitor. Brain Res. 739:104–110. 1996. View Article : Google Scholar : PubMed/NCBI

48 

Morais MC, Luqman S, Kondratyuk TP, Petronio MS, Regasini LO, Silva DH, Bolzani VS, Soares CP and Pezzuto JM: Suppression of TNF-α induced NFκB activity by gallic acid and its semi-synthetic esters: possible role in cancer chemoprevention. Nat Prod Res. 24:1758–1765. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Choi KC, Lee YH, Jung MG, Kwon SH, Kim MJ, Jun WJ, Lee J, Lee JM and Yoon HG: Gallic acid suppresses lipopolysaccharide-induced nuclear factor-kappaB signaling by preventing RelA acetylation in A549 lung cancer cells. Mol Cancer Res. 7:2011–2021. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Bains M and Hall ED: Antioxidant therapies in traumatic brain and spinal cord injury. Biochim Biophys Acta. 1822:675–684. 2012. View Article : Google Scholar

51 

Fleming JC, Norenberg MD, Ramsay DA, Dekaban GA, Marcillo AE, Saenz AD, Pasquale-Styles M, Dietrich WD and Weaver LC: The cellular inflammatory response in human spinal cords after injury. Brain. 129:3249–3269. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Oyinbo CA: Secondary injury mechanisms in traumatic spinal cord injury: A nugget of this multiply cascade. Acta Neurobiol Exp (Wars). 71:281–299. 2011.

53 

Carageorgiou H, Tzotzes V, Pantos C, Mourouzis C, Zarros A and Tsakiris S: In vivo and in vitro effects of cadmium on adult rat brain total antioxidant status, acetylcholinesterase, (Na+, K+)-ATPase and Mg2+-ATPase activities: protection by L-cysteine. Basic Clin Pharmacol Toxicol. 94:112–118. 2004. View Article : Google Scholar : PubMed/NCBI

54 

Vijaya Padma V, Poornima P, Prakash C and Bhavani R: Oral treatment with gallic acid and quercetin alleviates lindane-induced cardiotoxicity in rats. Can J Physiol Pharmacol. 91:134–140. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang YH, Wang Z, Zheng J and Wang R: Protective effects of gallic acid against spinal cord injury‑induced oxidative stress. Mol Med Rep 12: 3017-3024, 2015.
APA
Yang, Y.H., Wang, Z., Zheng, J., & Wang, R. (2015). Protective effects of gallic acid against spinal cord injury‑induced oxidative stress. Molecular Medicine Reports, 12, 3017-3024. https://doi.org/10.3892/mmr.2015.3738
MLA
Yang, Y. H., Wang, Z., Zheng, J., Wang, R."Protective effects of gallic acid against spinal cord injury‑induced oxidative stress". Molecular Medicine Reports 12.2 (2015): 3017-3024.
Chicago
Yang, Y. H., Wang, Z., Zheng, J., Wang, R."Protective effects of gallic acid against spinal cord injury‑induced oxidative stress". Molecular Medicine Reports 12, no. 2 (2015): 3017-3024. https://doi.org/10.3892/mmr.2015.3738
Copy and paste a formatted citation
x
Spandidos Publications style
Yang YH, Wang Z, Zheng J and Wang R: Protective effects of gallic acid against spinal cord injury‑induced oxidative stress. Mol Med Rep 12: 3017-3024, 2015.
APA
Yang, Y.H., Wang, Z., Zheng, J., & Wang, R. (2015). Protective effects of gallic acid against spinal cord injury‑induced oxidative stress. Molecular Medicine Reports, 12, 3017-3024. https://doi.org/10.3892/mmr.2015.3738
MLA
Yang, Y. H., Wang, Z., Zheng, J., Wang, R."Protective effects of gallic acid against spinal cord injury‑induced oxidative stress". Molecular Medicine Reports 12.2 (2015): 3017-3024.
Chicago
Yang, Y. H., Wang, Z., Zheng, J., Wang, R."Protective effects of gallic acid against spinal cord injury‑induced oxidative stress". Molecular Medicine Reports 12, no. 2 (2015): 3017-3024. https://doi.org/10.3892/mmr.2015.3738
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