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Article

Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice

  • Authors:
    • Tao Wang
    • Ji‑Na Lim
    • Jae‑Sung Lee
    • Sang‑Bum Lee
    • Jin‑Hee Hwang
    • U‑Suk Jung
    • Min‑Jeong Kim
    • Dae‑Youn Hwang
    • Sang‑Rak Lee
    • Sang‑Gun Roh
    • Hong‑Gu Lee
  • View Affiliations / Copyright

    Affiliations: Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China, Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, Republic of Korea, Department of Biomaterials Science, College of Natural Resources and Life Science, Pusan National University, Miryang, Gyeongnam 627‑706, Republic of Korea, Lab of Animal Physiology, Graduate School of Agriculture Science, Tohoku University, Sendai, Miyagi 988‑8555, Japan
  • Pages: 3200-3206
    |
    Published online on: May 8, 2015
       https://doi.org/10.3892/mmr.2015.3767
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Abstract

The aim of the present study was to investigate the effects of dietary trans fatty acids in mice. Following the administration of a 0.5/100 g diet of trans‑9 octadecenoic acid (EA), trans‑11 vaccenic acid (TVA) or cis‑9, trans‑11 conjugated linoleic acid (CLA) for 4 weeks, the body weights and the weights of the liver, testis and mediastinal adipose tissue (MAT) of the animals gradually decreased (P<0.05). The EA group exhibited the lowest levels of magnesium and triglycerides (P<0.05). CLA increased villus length (P<0.05), while EA and TVA decreased villus length (P<0.05). The TVA group exhibited the lowest levels of low‑density lipoprotein and tumor necrosis factor‑α (P<0.05). Taken together, EA, TVA and CLA affected the physiological conditions of mice differently. The potential effects of three well-known fatty acids, including trans‑9 octadecenoic acid (EA), trans‑11 vaccenic acid (TVA) and cis‑9, trans‑11 conjugated linoleic acid (CLA), in animals or humans remain to be elucidated. Therefore, in the present study, 32 animals were randomly divided into four groups and administered a 0.5/100 g diet of EA, TVA or CLA for 4 weeks. The results demonstrated that the body weights and the weights of the liver, testis and mediastinal adipose tissue (MAT) of the animals gradually decreased (P<0.05). Blood was collected individually via the external jugular veins and the EA group exhibited the lowest levels of magnesium and triglycerides (P<0.05). CLA increased villus length (P<0.05), while EA and TVA decreased villus length (P<0.05). The TVA group exhibited the lowest levels of low‑density lipoprotein and tumor necrosis factor‑α (P<0.05). Taken together, EA, TVA and CLA affected the physiological conditions of mice differently and these may further our understanding of the various effects of these fatty acids on animals and humans.
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1 

Low JN, Scrimgeour C and Horton P: Elaidic acid (trans-9-octa-decenoic acid). Acta Cryst. E61:o3730–o3732. 2005.

2 

Bauman DE, Baumgard LH, Corl BA and Griinari JM: Biosynthesis of conjugated linoleic acid in ruminants. J Anim Sci. E77:1–15. 2000.

3 

Wang T and Lee HG: Advances in Research on cis-9, trans-11 Conjugated Linoleic Acid: A Major Functional Conjugated Linoleic Acid Isomer. Crit Rev Food Sci Nutr. 55:720–731. 2015. View Article : Google Scholar

4 

Wang Y, Lu J, Ruth MR, Goruk SD, Reaney MJ, Glimm DR, Vine DF, Field CJ and Proctor SD: Trans-11 vaccenic acid dietary supplementation induces hypolipidemic effects in JCR: LA-cp rats. J Nutr. 138:2117–2122. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Bassett C, Edel AL, Patenaude AF, McCullough RS, Blackwood DP, Chouinard PY, Paquin P, Lamarche B and Pierce GN: Dietary vaccenic acid has antiatherogenic effects in LDLr-/-Mice. J Nutr. 140:18–24. 2010. View Article : Google Scholar

6 

Dilzer A and Park YH: Implication of conjugated linoleic acid (CLA) in human health. Crit Rev Food Sci Nutr. 52:488–513. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Dupasquier CMC, Patenaude AF, Blackwood DP, Chouinard Y, Lamarche B and Pierce GN: Elaidic and vaccenic TFAs have different effects on atherosclerotic development in low density lipoprotein receptor deficient (LDLr-/-) mice. Ann Nutr Metab. 1:2662007.

8 

Lock AL, Horne CA, Bauman DE and Salter AM: Butter naturally enriched in conjugated linoleic acid and vaccenic acid alters tissue fatty acids and improves the plasma lipoprotein profile in cholesterol-fed hamsters. J Nutr. 135:1934–1939. 2005.PubMed/NCBI

9 

Roy A, Chardigny JM, Bauchart D, Ferlay A, Lorenz S, Durand D, Gruffat D, Faulconnier Y, Sébédio JL and Chilliard Y: Butters rich either in trans-10-C18:1 or in trans-11-C18:1 plus cis-9, trans-11 CLA differentially affect plasma lipids and aortic fatty streak in experimental atherosclerosis in rabbits. Animal. 1:467–476. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Valeille K, Ferezou J, Amsler G, Quignard-Boulange A, Parquet M, Gripois D, Dorovska-Taran V and Martin JCA: cis-9, trans-11-conjugated linoleic acid-rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster. Am J Physiol Renal Physiol. 289:H652–H659. 2005. View Article : Google Scholar

11 

Kanwar RK, Macgibbon AK, Black PN, Kanwar JR, Rowan A, Vale M and Krissansen GW: Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice. Clin Exp Allergy. 38:208–218. 2008.

12 

Craig-Schmidt MC: World-wide consumption of trans fatty acids. Atheroscler Suppl. 7:1–4. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Folch J, Lees M and Sloane Stanley GH: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 226:497–509. 1957.PubMed/NCBI

14 

Wang T, Oh JJ, Lim JN, Hong JE, Kim JH, Kim JH, Kang HS, Choi YJ and Lee HG: Effects of lactation stage and individual performance on milk cis-9, trans-11 conjugated linoleic acids content in dairy cows. Asian-Aust J Anim Sci. 26:189–194. 2013. View Article : Google Scholar

15 

Blewett HJ, Gerdung CA, Ruth MR, Proctor SD and Field CJ: Vaccenic acid favourably alters immune function in obese JCR: LA-cp rats. Br J Nutr. 102:526–536. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Anadon A, Martinez-Larranaga MR, Martinez MA, Ares I, Ramos E, Gomez-Cortes P, Juarez M and de la Fuente MA: 4-Week repeated oral dose toxicity study of dairy fat naturally enriched in vaccenic, rumenic and α-linolenic acids in rats. J Agric Food Chem. 59:8036–8046. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Payne JM: The Compton metabolic profile test. Proc R Soc Med. 65:181–183. 1972.PubMed/NCBI

18 

Kato Y, Ito M and Hirooka H: Genetic parameters of serum vitamin A and total cholesterol concentrations and the genetic relationships with carcass traits in an F1 cross between Japanese Black sires and Holstein dams. J Anim Sci. 89:951–958. 2011. View Article : Google Scholar

19 

Meijer GW, Tol AV, Berkel TV and Weststrate JA: Effect of dietary elaidic versus vaccenic acid on blood and liver lipids in the hamster. Atherosclerosis. 157:31–40. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Fournier N, Attia N, Rousseau-Ralliard D, Vedie B, Destaillats F, Grynberg A and Paul JL: Deleterious impact of elaidic fatty acid on ABCA1-mediated cholesterol efflux from mouse and human macrophages. Biochim Biophys Acta. 182:303–312. 2012. View Article : Google Scholar

21 

Abbey M and Nestel PJ: Plasma cholesteryl ester transfer protein activity is increased when trans-elaidic acid is substituted for cis-oleic acid in the diet. Atherosclerosis. 106:99–107. 1994. View Article : Google Scholar : PubMed/NCBI

22 

Jelinek DF, Andersson S, Slaughter CA and Russell DW: Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J Biol Chem. 265:8190–8197. 1990.PubMed/NCBI

23 

Ryan G; Tissue Engineering the Small Intestine. Clin Gastroenterol Hepatol. 11:354–358. 2013. View Article : Google Scholar

24 

Yang M and Cook ME: Dietary conjugated linoleic acid decreased cachexia, macrophage tumor necrosis factor-α production and modifies splenocyte cytokines production. Exp Biol Med (Maywood). 228:51–58. 2003.

25 

Zhao L, Yin J, Li D, Lai C, Chen X and Ma D: Conjugated linoleic acid can prevent tumor necrosis factor gene expression by inhibiting nuclear factor binding activity in peripheral blood mononuclear cells from weaned pigs challenged with lipopolysaccharide. Arch Anim Nutr. 59:429–438. 2005. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang T, Lim JN, Lee JS, Lee SB, Hwang JH, Jung US, Kim MJ, Hwang DY, Lee SR, Roh SG, Roh SG, et al: Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice. Mol Med Rep 12: 3200-3206, 2015.
APA
Wang, T., Lim, J., Lee, J., Lee, S., Hwang, J., Jung, U. ... Lee, H. (2015). Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice. Molecular Medicine Reports, 12, 3200-3206. https://doi.org/10.3892/mmr.2015.3767
MLA
Wang, T., Lim, J., Lee, J., Lee, S., Hwang, J., Jung, U., Kim, M., Hwang, D., Lee, S., Roh, S., Lee, H."Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice". Molecular Medicine Reports 12.2 (2015): 3200-3206.
Chicago
Wang, T., Lim, J., Lee, J., Lee, S., Hwang, J., Jung, U., Kim, M., Hwang, D., Lee, S., Roh, S., Lee, H."Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice". Molecular Medicine Reports 12, no. 2 (2015): 3200-3206. https://doi.org/10.3892/mmr.2015.3767
Copy and paste a formatted citation
x
Spandidos Publications style
Wang T, Lim JN, Lee JS, Lee SB, Hwang JH, Jung US, Kim MJ, Hwang DY, Lee SR, Roh SG, Roh SG, et al: Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice. Mol Med Rep 12: 3200-3206, 2015.
APA
Wang, T., Lim, J., Lee, J., Lee, S., Hwang, J., Jung, U. ... Lee, H. (2015). Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice. Molecular Medicine Reports, 12, 3200-3206. https://doi.org/10.3892/mmr.2015.3767
MLA
Wang, T., Lim, J., Lee, J., Lee, S., Hwang, J., Jung, U., Kim, M., Hwang, D., Lee, S., Roh, S., Lee, H."Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice". Molecular Medicine Reports 12.2 (2015): 3200-3206.
Chicago
Wang, T., Lim, J., Lee, J., Lee, S., Hwang, J., Jung, U., Kim, M., Hwang, D., Lee, S., Roh, S., Lee, H."Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice". Molecular Medicine Reports 12, no. 2 (2015): 3200-3206. https://doi.org/10.3892/mmr.2015.3767
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