Future opportunities in preventing ototoxicity: Caffeic acid phenethyl ester may be a candidate (Review)

Akyol,Sumeyya; Isik,Bunyamin; Altuntas,Aynur; Erden,Gonul; Cakmak,Ozlem; Kurşunlu,S.   Fatih; Adam,Bahattin; Akyol,Omer

doi:10.3892/mmr.2015.3785

Future opportunities in preventing ototoxicity: Caffeic acid phenethyl ester may be a candidate (Review)

Authors:
- Sumeyya Akyol
- Bunyamin Isik
- Aynur Altuntas
- Gonul Erden
- Ozlem Cakmak
- S. Fatih Kurşunlu
- Bahattin Adam
- Omer Akyol
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Affiliations: Department of Medical Biology, Medical Faculty, Turgut Ozal University, Ankara 06170, Turkey, Department of Family Medicine, Medical Faculty, Hacettepe University, Ankara 06100, Turkey, Division of Chemistry, Ankara Regional Office of Council of Forensic Medicine, Ankara 06300, Turkey, Department of Medical Biochemistry, Medical Faculty, Hacettepe University, Ankara 06100, Turkey, Department of Biology, Faculty of Education, Gazi University, Ankara 06500, Turkey, Department of Periodontology, Faculty of Dentistry, Adnan Menderes University, Aydin 09100, Turkey, San Jose State University, San Jose 95101, CA, USA
Published online on: May 14, 2015 https://doi.org/10.3892/mmr.2015.3785
Pages: 3231-3235

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Abstract

Caffeic acid phenethyl ester (CAPE) is an important active component of propolis, which is derived from honeybee hives. It has received increasing attention in a variety of medical and pharmaceutical research, due to its anti‑oxidant, antiproliferative, anti‑inflammatory, antiviral and antifungal activity, in addition to its antineoplastic properties. Besides the use of CAPE as an antioxidant and anti‑inflammatory agent in a number of in vivo studies of ear disease, its beneficial effects have been reported in the treatment of cancer, arthritis, allergies, heart disease, diabetes, kidney disease, liver disease and neurological disease. CAPE influences a number of biochemical pathways, as well as several targets involved in ear diseases, in particular, in ototoxicity. The protective effects of CAPE in ototoxicity, which may be induced by a number factors, including lipopolysaccharides, hydrogen peroxide and streptomycin, are evaluated and discussed in the present review.

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