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Article Open Access

Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines

Retraction in: /10.3892/mmr.2025.13638
  • Authors:
    • Yan Zhang
    • Nina Fan
    • Jing Yang
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Gynaecology and Obstetrics, Hubei Xinhau Hospital, Wuhan, Hubei 430060, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3393-3399
    |
    Published online on: May 14, 2015
       https://doi.org/10.3892/mmr.2015.3786
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Abstract

The aim of the present study was to investigate the expression and clinical significance of hypoxia-inducible factor 1α (HIF-1α), Snail and E-cadherin in ovarian cancer. The expression levels were assessed in a number of ovarian cancer cell lines and ovarian cancer tissues, and correlations between the expression of the three proteins and clinical pathological factors were analyzed. Transwell assays showed that the invasive ability of the ovarian cancer cell lines SKOV3 and ES‑2 were significantly higher than those of TYK and 3AO (P<0.01). Furthermore, the expression levels of HIF‑1α and Snail in SKOV3 and ES‑2 were significantly higher than those in TYK and 3AO, whereas the expression levels of E‑cadherin in SKOV3 and ES‑2 were significantly lower than those in TYK and 3AO (P<0.05). In ovarian cancer tissues, the expression levels of HIF‑1α, Snail and E‑cadherin were correlated with clinical pathological factors (P<0.01); furthermore, there was a positive correlation between the expression levels of HIF‑1α and Snail (r=0.231; P=0.021), and a negative correlation between the expression levels of Snail and that of E‑cadherin (r=‑0.225; P=0.028). HIF‑1α was suggested to be able to suppress the expression of E‑cadherin by upregulating Snail, thus serving an important role in invasion and metastasis of ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Fan N and Yang J: Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines Retraction in /10.3892/mmr.2025.13638. Mol Med Rep 12: 3393-3399, 2015.
APA
Zhang, Y., Fan, N., & Yang, J. (2015). Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines Retraction in /10.3892/mmr.2025.13638. Molecular Medicine Reports, 12, 3393-3399. https://doi.org/10.3892/mmr.2015.3786
MLA
Zhang, Y., Fan, N., Yang, J."Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines Retraction in /10.3892/mmr.2025.13638". Molecular Medicine Reports 12.3 (2015): 3393-3399.
Chicago
Zhang, Y., Fan, N., Yang, J."Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines Retraction in /10.3892/mmr.2025.13638". Molecular Medicine Reports 12, no. 3 (2015): 3393-3399. https://doi.org/10.3892/mmr.2015.3786
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Fan N and Yang J: Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines Retraction in /10.3892/mmr.2025.13638. Mol Med Rep 12: 3393-3399, 2015.
APA
Zhang, Y., Fan, N., & Yang, J. (2015). Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines Retraction in /10.3892/mmr.2025.13638. Molecular Medicine Reports, 12, 3393-3399. https://doi.org/10.3892/mmr.2015.3786
MLA
Zhang, Y., Fan, N., Yang, J."Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines Retraction in /10.3892/mmr.2025.13638". Molecular Medicine Reports 12.3 (2015): 3393-3399.
Chicago
Zhang, Y., Fan, N., Yang, J."Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines Retraction in /10.3892/mmr.2025.13638". Molecular Medicine Reports 12, no. 3 (2015): 3393-3399. https://doi.org/10.3892/mmr.2015.3786
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