Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2015 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Inflammation and oxidative stress, rather than hypoxia, are predominant factors promoting angiogenesis in the initial phases of atherosclerosis

  • Authors:
    • Weigang Xiao
    • Zhenhua Jia
    • Qiuyan Zhang
    • Cong Wei
    • Hongtao Wang
    • Yiling Wu
  • View Affiliations / Copyright

    Affiliations: Graduate School Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Cardiovascular Medicine, Affiliated Yiling Hospital of Hebei Medical University, Shijiazhuang, Hebei 050091, P.R. China, Pharmacology Lab, Yiling Pharmaceutical Research Institute, Shijiazhuang, Hebei 050035, P.R. China, Key Laboratory of State Administration of Traditional Chinese Medicine, Shijiazhuang, Hebei 050035, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3315-3322
    |
    Published online on: May 19, 2015
       https://doi.org/10.3892/mmr.2015.3800
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Micro-angiogenesis in the arterial wall has been observed during the development and progression of atherosclerosis. The aim of the present study was to examine whether inflammation, oxidative stress and hypoxia are involved in the process of early atherosclerotic micro‑angiogenesis. A total of 24 rabbits were randomly divided into a normal diet group or a high‑cholesterol (HC) diet group and were fed the corresponding diets for 4 weeks. The microvessel density (MVD), level of hypoxia and the levels of inflammatory markers and antioxidants in the arterial wall were detected using immunohistochemical and molecular biological techniques, respectively. The present results demonstrated that the MVD in the HC group was significantly higher (P<0.01) than that observed in the rabbits, which were provided with a normal diet, while hypoxia‑inducible factor‑1α levels did not exhibit marked changes in either of the two groups (P>0.05). The levels of inflammatory markers and antioxidants were significantly different between the two groups (P<0.05). The present study demonstrated that the primary factors, which promote micro‑angiogenesis are possibly associated with an increase in inflammation and a decrease in the levels of antioxidants, as tissue hypoxia in the arterial wall at this stage was not evident.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ross R: Atherosclerosis - an inflammatory disease. N Engl J Med. 340:115–126. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Gustafson B: Adipose tissue, inflammation and atherosclerosis. J Atheroscler Thromb. 17:332–341. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Madamanchi NR, Vendrov A and Runge MS: Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol. 25:29–38. 2005.

4 

Moreno PR, Purushothaman KR, Sirol M, Levy AP and Fuster V: Neovascularization in human atherosclerosis. Circulation. 113:2245–2252. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Silva ES, Giglio PN, Waisberg DR, Filho RG, Casella IB and Puech-Leäo P: Obesity is a risk factor for significant carotid atherosclerosis in patients aged 39 to 55 years. Angiology. 65:602–606. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Hildebrandt HA, Gossl M, Mannheim D, et al: Differential distribution of vasa vasorum in different vascular beds in humans. Atherosclerosis. 199:47–54. 2008. View Article : Google Scholar

7 

Galili O, Herrmann J, Woodrum J, Sattler KJ, Lerman LO and Lerman A: Adventitial vasa vasorum heterogeneity among different vascular beds. J Vasc Surg. 40:529–535. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Langheinrich AC, Michniewicz A, Bohle RM and Ritman EL: Vasa vasorum neovascularization and lesion distribution among different vascular beds in ApoE−/−/LDL−/− double knockout mice. Atherosclerosis. 191:73–81. 2007. View Article : Google Scholar

9 

Kumamoto M, Nakashima Y and Sueishi K: Intimal neovas-cularization in human coronary atherosclerosis: its origin and pathophysiological significance. Hum Pathol. 26:450–456. 1995. View Article : Google Scholar : PubMed/NCBI

10 

Moulton KS, Vakili K, Zurakowski D, et al: Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis. Proc Natl Acad Sci USA. 100:4736–4741. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Herrmann J, Lerman LO, Rodriguez-Porcel M, et al: Coronary vasa vasorum neovascularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia. Cardiovasc Res. 51:762–766. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Sluimer JC and Daemen MJ: Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis. J Pathol. 218:7–29. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Jeziorska M and Woolley DE: Neovascularization in early atherosclerotic lesions of human carotid arteries: its potential contribution to plaque development. Hum Pathol. 30:919–925. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Santilli SM, Kronson J and Payne WD: The effect of hypercholesterolemia on the rabbit transarterial wall oxygen gradient. Ann Vasc Surg. 12:418–423. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Tonar Z, Kural T Jr, Kochová P, Nedorost L and Witter K: Vasa vasorum quantification in human varicose great and small saphenous veins. Ann Anat. 194:473–481. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Khurana R, Zhuang Z, Bhardwaj S, et al: Angiogenesis-dependent and independent phases of intimal hyperplasia. Circulation. 110:2436–2443. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Barger AC, Beeuwkes R III, Lainey LL and Silverman KJ: Hypothesis: vasa vasorum and neovascularization of human coronary arteries. A possible role in the pathophysiology of atherosclerosis. N Engl J Med. 310:175–177. 1984. View Article : Google Scholar : PubMed/NCBI

18 

Wilson SH, Herrmann J, Lerman LO, et al: Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering. Circulation. 105:415–418. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Wilson SH, Caplice NM, Simari RD, Holmes DR Jr, Carlson PJ and Lerman A: Activated nuclear factor-κB is present in the coronary vasculature in experimental hypercholesterolemia. Atherosclerosis. 148:23–30. 2000. View Article : Google Scholar

20 

Wu N, Zhang X and Jia D: Highdose fasudil preconditioning and postconditioning attenuate myocardial ischemia reperfusion injury in hypercholesterolemic rats. Mol Med Rep. 9:560–566. 2014.

21 

Johnston DA, Dong B and Hughes CC: TNF induction of jagged-1 in endothelial cells is NFκB-dependent. Gene. 435:36–44. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Leibovich SJ, Polverini PJ, Shepard HM, Wiseman DM, Shively V and Nuseir N: Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α. Nature. 329:630–632. 1987. View Article : Google Scholar : PubMed/NCBI

23 

Salani D, Taraboletti G, Rosano L, et al: Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Am J Pathol. 157:1703–1711. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Herrmann J, Best PJ, Ritman EL, Holmes DR Jr, Lerman LO and Lerman A: Chronic endothelin receptor antagonism prevents coronary vasa vasorum neovascularization in experimental hypercholesterolemia. J Am Coll Cardiol. 39:1555–1561. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Quehenberger P, Bierhaus A, Fasching P, et al: Endothelin 1 transcription is controlled by nuclear factor-κB in AGE-stimulated cultured endothelial cells. Diabetes. 49:1561–1570. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Duracková Z: Some current insights into oxidative stress. Physiol Res. 59:459–469. 2010.

27 

Kondo T, Hirose M and Kageyama K: Roles of oxidative stress and redox regulation in atherosclerosis. J Atheroscler Thromb. 16:532–538. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Armstrong AW, Voyles SV, Armstrong EJ, Fuller EN and Rutledge JC: Angiogenesis and oxidative stress: common mechanisms linking psoriasis with atherosclerosis. J Dermatol Sci. 63:1–9. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Ma Q: Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol. 53:401–426. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Lee JM and Johnson JA: An important role of Nrf2-ARE pathway in the cellular defense mechanism. J Biochem Mol Biol. 37:139–143. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Zakkar M, Van der Heiden K, Luong A, et al: Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol. 29:1851–1857. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Aoki M, Nata T, Morishita R, et al: Endothelial apoptosis induced by oxidative stress through activation of NF-κB: antiapoptotic effect of antioxidant agents on endothelial cells. Hypertension. 38:48–55. 2001. View Article : Google Scholar : PubMed/NCBI

33 

West XZ, Malinin NL, Merkulova AA, et al: Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature. 467:972–976. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Okuno Y, Nakamura-Ishizu A, Otsu K, Suda T and Kubota Y: Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat Med. 18:1208–1216. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xiao W, Jia Z, Zhang Q, Wei C, Wang H and Wu Y: Inflammation and oxidative stress, rather than hypoxia, are predominant factors promoting angiogenesis in the initial phases of atherosclerosis. Mol Med Rep 12: 3315-3322, 2015.
APA
Xiao, W., Jia, Z., Zhang, Q., Wei, C., Wang, H., & Wu, Y. (2015). Inflammation and oxidative stress, rather than hypoxia, are predominant factors promoting angiogenesis in the initial phases of atherosclerosis. Molecular Medicine Reports, 12, 3315-3322. https://doi.org/10.3892/mmr.2015.3800
MLA
Xiao, W., Jia, Z., Zhang, Q., Wei, C., Wang, H., Wu, Y."Inflammation and oxidative stress, rather than hypoxia, are predominant factors promoting angiogenesis in the initial phases of atherosclerosis". Molecular Medicine Reports 12.3 (2015): 3315-3322.
Chicago
Xiao, W., Jia, Z., Zhang, Q., Wei, C., Wang, H., Wu, Y."Inflammation and oxidative stress, rather than hypoxia, are predominant factors promoting angiogenesis in the initial phases of atherosclerosis". Molecular Medicine Reports 12, no. 3 (2015): 3315-3322. https://doi.org/10.3892/mmr.2015.3800
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao W, Jia Z, Zhang Q, Wei C, Wang H and Wu Y: Inflammation and oxidative stress, rather than hypoxia, are predominant factors promoting angiogenesis in the initial phases of atherosclerosis. Mol Med Rep 12: 3315-3322, 2015.
APA
Xiao, W., Jia, Z., Zhang, Q., Wei, C., Wang, H., & Wu, Y. (2015). Inflammation and oxidative stress, rather than hypoxia, are predominant factors promoting angiogenesis in the initial phases of atherosclerosis. Molecular Medicine Reports, 12, 3315-3322. https://doi.org/10.3892/mmr.2015.3800
MLA
Xiao, W., Jia, Z., Zhang, Q., Wei, C., Wang, H., Wu, Y."Inflammation and oxidative stress, rather than hypoxia, are predominant factors promoting angiogenesis in the initial phases of atherosclerosis". Molecular Medicine Reports 12.3 (2015): 3315-3322.
Chicago
Xiao, W., Jia, Z., Zhang, Q., Wei, C., Wang, H., Wu, Y."Inflammation and oxidative stress, rather than hypoxia, are predominant factors promoting angiogenesis in the initial phases of atherosclerosis". Molecular Medicine Reports 12, no. 3 (2015): 3315-3322. https://doi.org/10.3892/mmr.2015.3800
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team