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Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats

  • Authors:
    • Gang Liu
    • Chao Liu
    • Xue‑Ning Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, General Hospital of Beijing Military Area of PLA, Beijing 100700, P.R. China, Department of Anesthesiology, Tianjin Chest Hospital, Tianjin 300222, P.R. China, Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3297-3308
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    Published online on: May 21, 2015
       https://doi.org/10.3892/mmr.2015.3803
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Abstract

The present study aimed to examine the neurophysiological mechanisms of the 2,6-diisopropylphenol and N-methyl-D-aspartate (NMDA) receptor antagonist against learning and memory impairment, induced by electroconvulsive therapy (ECT). A total of 48 adult depressed rats without olfactory bulbs were randomly divided into six experimental groups: i) saline; ii) 10 mg/kg MK‑801; iii) 10 mg/kg MK‑801 and a course of ECT; iv) 200 mg/kg 2,6‑diisopropylphenol; v) 200 mg/kg 2,6‑diisopropylphenol and a course of ECT; and vi) saline and a course of ECT. The learning and memory abilities of the rats were assessed using a Morris water maze 1 day after a course of ECT. The hippocampus was removed 1 day after assessment using the Morris water maze assessment. The content of glutamate in the hippocampus was detected using high‑performance liquid chromatography. The expression levels of p‑AT8Ser202 and GSK‑3β1H8 in the hippocampus were determined using immunohistochemical staining and western blot analysis. The results demonstrated that the 2,6‑diisopropylphenol NMDA receptor antagonist, MK‑801 and ECT induced learning and memory impairment in the depressed rats. The glutamate content was significantly upregulated by ECT, reduced by 2,6‑diisopropylphenol, and was unaffected by the NMDA receptor antagonist in the hippocampus of the depressed rats. Tau protein hyperphosphorylation in the hippocampus was upregulated by ECT, but was reduced by 2,6‑diisopropylphenol and the MK‑801 NMDA receptor antagonist. It was also demonstrated that 2,6‑diisopropylphenol prevented learning and memory impairment and reduced the hyperphosphorylation of the Tau protein, which was induced by eECT. GSK‑3β was found to be the key protein involved in this signaling pathway. The ECT reduced the learning and memory impairment, caused by hyperphosphorylation of the Tau protein, in the depressed rats by upregulating the glutamate content.
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1 

Ebert MH: Current diagnosis and treatment psychiatry. 2nd ed. Mc Graw-Hill Press; New York: 2008

2 

Conrad MS and Richard A: The handbook for electroconvulsive therapy. 1st ed. Eagle Race Medical Technologies Company Press; California: 1999

3 

Luo J, Mins, Wei K, Li P, Dong J and Liu YF: Propofol protects against impairment of learning-memory and imbalance of hippocampal Glu/GABA induced by electroconvulsive shock in depressed rats. J Anesth. 25:657–665. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Andrade C, Singh NM, Thyagarajan S, Nagaraja N, Sanjay Kumar Rao N and Suresh Chandra J: Possible glutamatergic and lipid signalling mechanisms in ECT-induced retrograde amnesia: experimental evidence for involvement of COX-2 and review of literature. J Psychiatr Res. 42:837–850. 2008. View Article : Google Scholar

5 

Dong J, Mins, Wei K, Li P, Cao J and Li Y: Effects of electroconvulsive therapy and propofol on spatial memory and glutamatergic system in hippocampus of depressed rats. J ECT. 26:126–130. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Kartalcis, Karabulut AB, Ozcan AC, Porgali E and Unal S: Acute and chronic effects of electroconvulsive treatment on oxidative parameters in schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry. 35:1689–1694. 2011. View Article : Google Scholar

7 

Kato N: Neurophysiological mechanisms of electroconvulsive therapy for depression. Neurosci Res. 64:3–11. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Weingarten MD, Lockwood AH, Hwos Y and Kirschner MW: A protein factor essential for microtubule assembly. Proc Natl Acad Sci USA. 72:1858–1862. 1975. View Article : Google Scholar : PubMed/NCBI

9 

Osiecka KM, Nieznanska H, Skowronek KJ, Jozwiak J and Nieznanski K: Tau inhibits tubulin oligomerization induced by prion protein. Biochim Biophys Acta. 1813:1845–1853. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Cleveland DW, Hwo SY and Kirschner MW: Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol. 116:207–225. 1977. View Article : Google Scholar : PubMed/NCBI

11 

Onishi T, Matsumoto Y, Hattori M, Obayashi Y, Nakamura K, Yano T, Horiguchi T and Iwashita H: Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice. Neurosci Res. 80:76–85. 2014. View Article : Google Scholar : PubMed/NCBI

12 

de Calignon A, Fox LM, Pitstick R, et al: Caspase activation precedes and leads to tangles. Nature. 464:1201–1204. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Combs B, Voss K and Gamblin TC: Pseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms. Biochemistry. 50:9446–9456. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Canu N, Filesi I, Pristerà A, Ciotti MT and Bioccas: Altered intracellular distribution of PrPC and impairment of proteasome activity in tau overexpressing cortical neurons. J Alzheimers Dis. 27:603–613. 2011.PubMed/NCBI

15 

Onishi T, Iwashita H, Uno Y, et al: A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease. J Neurochem. 119:1330–1340. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Kopeikina KJ, Carlson GA, Pitstick R, et al: Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am J Pathol. 179:2071–2082. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Annamalai B, Won JS, Choi S, Singh I and Singh AK: Role of S-nitrosoglutathione mediated mechanisms in tau hyper-phosphorylation. Biochem Biophys Res Commun. 458:214–219. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Wang Q, Zhang JY, Liu SJ and Li HL: Overactivated mitogen-activated protein kinase by anisomycin induces tau hyperphosphorylation. Sheng Li Xue Bao. 60:485–491. 2008.PubMed/NCBI

19 

Fu ZQ, Yang Y, Song J, et al: LiCl attenuates thapsigargin induced tau hyperphosphorylation by inhibiting GSK-3beta in vivo and in vitro. J Alzheimers Dis. 21:1107–1117. 2010.

20 

De Vos A, Anandhakumar J, Van den Brande J, et al: Yeast as a model system to study tau biology. Int J Alzheimers Dis. 2011:4289702011. View Article : Google Scholar : PubMed/NCBI

21 

Blazquez Llorca L, Garcia-Marin V, Merino-Serrais P, Ávila J and DeFelipe J: Abnormal tau phosphorylation in the thorny excrescences of CA3 hippocampal neurons in patients with Alzheimer's disease. J Alzheimers Dis. 26:683–698. 2011.PubMed/NCBI

22 

Bibow S, Ozenne V, Biernat J, Blackledge M, Mandelkow E and Zweckstetter M: Structural impact of proline-directed pseudophosphorylation at AT8, AT100 and PHF1 epitopes on 441 residue tau. J Am Chem Soc. 133:15842–15845. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Ray P, Kar A, Fushimi K, Havlioglu N, Chen X and Wu JY: PSF suppresses tau exon 10 inclusion by interacting with a stem-loop structure downstream of exon 10. J Mol Neurosci. 45:453–466. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Bibows, Mukrasch MD, Chinnathambis, et al: The dynamic structure of filamentous tau. Angew Chem Int Ed Engl. 50:11520–11524. 2011. View Article : Google Scholar

25 

Chin PC, Majdzadeh N and D'Mellos R: Inhibition of GSK3beta is a common event in neuroprotection by different survival factors. Brain Res Mol Brain Res. 137:193–201. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Lehtihet M, Webb DL, Honkanen RE and Sjöholm A: Glutamate inhibits protein phosphatases and promotes insulin exocytosis in pancreatic beta-cells. Biochem Biophys Res Commun. 328:601–607. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Tasset I, Medina FJ, Peña J, et al: Olfactory bulbectomy induced oxidative and cell damage in rat: protective effect of melatonin. Physiol Res. 59:105–112. 2010.

28 

Wang D, Noda Y, Tsunekawa H, et al: Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety. Behav Brain Res. 178:262–273. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Mutlu O, Ulak G, Celikyurt IK, Akar FY, Erden F and Tanyeri P: Effects of olanzapine, sertindole and clozapine on MK-801 induced visual memory deficits in mice. Pharmacol Biochem Behav. 99:557–565. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Altar CA, Laeng P, Jurata LW, et al: Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways. J Neurosci. 24:2667–2677. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Kato S, Kito Y, Hemmi H and Yoshimura T: Simultaneous determination of D-amino acids by the coupling method of D-amino acid oxidase with high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 879:3190–3195. 2011. View Article : Google Scholar

32 

Wu FY, Feng Q, Cheng M, Yan J, Xu YX and Zhu CQ: The activation of excitatory amino acid receptors is involved in tau phosphorylation induced by cold water stress. Prog Biochem Biophys. 37:510–516. 2010. View Article : Google Scholar

33 

Choi BR, Kwon KJ, Park SH, et al: Alternations of septal-hippocampal system in the adult wistar rat with spatial memory impairments induced by chronic cerebral hypoperfusion. Exp Neurobiol. 20:92–99. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Preissmann D, Bertholet L, Sierro G, Cabungcal JH and Schenk F: Accurate performance of a rat model of schizophrenia in the water maze depends on visual cue availability and stability: a distortion in cognitive mapping abilities? Behav Brain Res. 223:145–153. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Carroll JC, Iba M, Bangasser DA, et al: Chronic stress exacerbates tau pathology, neurodegeneration and cognitive performance through a corticotrophin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy. J Neurosci. 31:14436–14449. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Dumont JR, Amin E, Wright NF, Dillingham CM and Aggleton JP: The impact of fornix lesions in rats on spatial learning tasks sensitive to anterior thalamic and hippocampal damage. Behav Brain Res. 278:360–374. 2015. View Article : Google Scholar

37 

Palmio J, Huuhka M, Laines, et al: Electroconvulsive therapy and biomarkers of neuronal injury and plasticity: Serum levels of neuron-specific enolase and S-100b protein. Psychiatry Res. 177:97–100. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Zhu X, Hao X, Luo J, Min S, Xie F and Zhang F: Propofol inhibits inflammatory cytokine-mediated glutamate uptake dysfunction to alleviate learning/memory impairment in depressed rats undergoing electroconvulsive shock. Brain Res. 1595:101–109. 2015. View Article : Google Scholar

39 

Kloda A, Martinac B and Adams DJ: Polymodal regulation of NMDA receptor channels. Channels (Austin). 1:334–343. 2007. View Article : Google Scholar

40 

Stover JF and Kempski OS: Anesthesia increases circulating glutamate in neurosurgical patients. Acta Neurochir (Wien). 147:847–853. 2005. View Article : Google Scholar

41 

Feiner JR, Bickler PE, Estradas, Donohoe PH, Fahlman CS and Schuyler JA: Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures. Anesth Analg. 100:215–225. 2005. View Article : Google Scholar

42 

Li KY, Guan YZ, Krnjević K and Ye JH: Propofol facilitates glutamatergic transmission to neurons of the ventrolateral preoptic nucleus. Anesthesiology. 111:1271–1278. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Pesić V, Milanović D, Tanić N, et al: Potential mechanism of cell death in the developing rat brain induced by propofol anesthesia. Int J Dev Neurosci. 27:279–287. 2009. View Article : Google Scholar

44 

Nie CL, Wang XS, Liu Y, Perretts and He RQ: Amyloid-like aggregates of neuronal tau induced by formaldehyde promote apoptosis of neuronal cells. BMC Neurosci. 8:92007. View Article : Google Scholar : PubMed/NCBI

45 

Yao Z, Guo Z, Yang C, et al: Phenylbutyric acid prevents rats from electroconvulsion-induced memory deficit with alterations of memory-related proteins and tau hyperphosphorylation. Neuroscience. 168:405–415. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Bulbarelli A, Lonati E, Cazzaniga E, Gregori M and Masserini M: Pin1 affects Tau phosphorylation in response to Abeta oligomers. Mol Cell Neurosci. 42:75–80. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Jeon S, Kim YS, Park J and Bae CD: Microtubule affinity-regulating kinase 1 (MARK1) is activated by electroconvulsive shock in the rat hippocampus. J Neurochem. 95:1608–1618. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Tan W, Cao X, Wang J, Lv H, Wu B and Ma H: Tau hyper-phosphorylation is associated with memory impairment after exposure to 1.5% isoflurane without temperature maintenance in rats. Eur J Anaesthesiol. 27:835–841. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Vossel KA, Zhang K, Brodbeck J, et al: Tau reduction prevents Abeta-induced defects in axonal transport. Science. 330:1982010. View Article : Google Scholar : PubMed/NCBI

50 

Allyson J, Dontigny E, Auberson Y, Cyr M and Massicotte G: Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices. Neural Plast. 2010:3401682010.PubMed/NCBI

51 

Sato S, Xu J, Okuyamas, et al: Spatial learning impairment, enhanced CDK5/p35 activity and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J Neurosci. 28:14511–14521. 2008. View Article : Google Scholar

52 

Muyllaert D, Kremer A, Jaworski T, et al: Glycogen synthase kinase-3beta, or a link between amyloid and tau pathology? Genes Brain Behav. 7(Suppl 1): 57–66. 2008. View Article : Google Scholar : PubMed/NCBI

53 

Liu C, Zhang XN, Liu D and Min S: Effects of propofol, ginsenoside Rg-1, protein phosphatase-2a, and lithium on the learning and memory in rats and the content of glutamic acid in hippocampus after the electroconvulsive therapy. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 36:234–240. 2014.PubMed/NCBI

54 

Xu JJ and Wang YL: Propofol attenuation of hydrogen peroxide-mediated oxidative stress and apoptosis in cultured cardiomyocytes involves haeme oxygenase-1. Eur J Anaesthesiol. 25:395–402. 2008. View Article : Google Scholar : PubMed/NCBI

55 

Straiko MM, Young C, Cattano D, et al: Lithium protects against anesthesia-induced developmental neuroapoptosis. Anesthesiology. 110:862–868. 2009. View Article : Google Scholar : PubMed/NCBI

56 

Lesort M, Blanchard C, Yardin C, Esclaire F and Hugon J: Cultured neurons expressing phosphorylated tau are more resistant to apoptosis induced by NMDA or serum deprivation. Brain Res Mol Brain Res. 45:127–132. 1997. View Article : Google Scholar : PubMed/NCBI

57 

Klein RC, Warder SE, Galdzicki Z, Castellino FJ and Prorok M: Kinetic and mechanistic characterization of NMDA receptor antagonism by replacement and truncation variants of the conantokin peptides. Neuropharmacology. 41:801–810. 2001. View Article : Google Scholar : PubMed/NCBI

58 

Amadoro G, Ciotti MT, Costanzi M, Cestari V, Calissano P and Canu N: NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proc Natl Acad Sci USA. 103:2892–2897. 2006. View Article : Google Scholar : PubMed/NCBI

59 

Paterlini M, Valerio A, Baruzzi F, Memo M and Spano PF: Opposing regulation of tau protein levels by ionotropic and metabotropic glutamate receptors in human NT2 neurons. Neurosci Lett. 243:77–80. 1998. View Article : Google Scholar : PubMed/NCBI

60 

Elyaman W, Terro F, Wong NS and Hugon J: In vivo activation and nuclear translocation of phosphorylated glycogen synthase kinase-3beta in neuronal apoptosis: links to tau phosphorylation. Eur J Neurosci. 15:651–660. 2002. View Article : Google Scholar : PubMed/NCBI

61 

Burnouf S, Martire A, Derisbourg M, et al: NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging Cell. 12:11–23. 2013. View Article : Google Scholar

62 

Mondragón-Rodríguez S, Trillaud-Doppia E, Dudilot A, et al: Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor dependent tau phosphorylation. J Biol Chem. 287:32040–32053. 2012. View Article : Google Scholar

63 

Chen NN, Luo DJ, Yao XQ, et al: Pesticides induce spatial memory deficits with synaptic impairments and an imbalanced tau phosphorylation in rats. J Alzheimers Dis. 30:585–594. 2012.PubMed/NCBI

64 

Kingston S, Mao L, Yang L, Arora A, Fibuch EE and Wang JQ: Propofol inhibits phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in neurons. Anesthesiology. 104:763–769. 2006. View Article : Google Scholar : PubMed/NCBI

65 

Hama-Tomioka K, Kinoshita H, Nakahata K, et al: Roles of neuronal nitric oxide synthase, oxidative stress and propofol in N-methyl-D-aspartate-induced dilatation of cerebral arterioles. Br J Anaesth. 108:21–29. 2012. View Article : Google Scholar

66 

Li X, Li W, Luo J, et al: Effects of propofol on the activation of hippocampal CaMKIIalpha in depressed rats receiving electroconvulsive therapy. J ECT. 28:242–247. 2012. View Article : Google Scholar : PubMed/NCBI

67 

Wang HY, Wang GL, Yu YH and Wang Y: The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. Brain Res. 1297:177–184. 2009. View Article : Google Scholar : PubMed/NCBI

68 

Freitas AE, Machado DG, Budni J, et al: Antidepressant-like action of the bark ethanolic extract from Tabebuia avellanedae in the olfactory bulbectomized mice. J Ethnopharmacol. 145:737–745. 2013. View Article : Google Scholar

69 

Flores-Rodríguez P, Ontiveros Torres MA, Cárdenas-Aguayo MC, et al: The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease. Front Neurosci. 9:332015.PubMed/NCBI

70 

Qu X, Xu C, Wang H, et al: Hippocampal glutamate level and glutamate aspartate transporter (GLAST) are up-regulated in senior rat associated with isoflurane induced spatial learning/memory impairment. Neurochem Res. 38:59–73. 2013. View Article : Google Scholar

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Liu G, Liu C and Zhang XN: Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats. Mol Med Rep 12: 3297-3308, 2015.
APA
Liu, G., Liu, C., & Zhang, X. (2015). Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats. Molecular Medicine Reports, 12, 3297-3308. https://doi.org/10.3892/mmr.2015.3803
MLA
Liu, G., Liu, C., Zhang, X."Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats". Molecular Medicine Reports 12.3 (2015): 3297-3308.
Chicago
Liu, G., Liu, C., Zhang, X."Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats". Molecular Medicine Reports 12, no. 3 (2015): 3297-3308. https://doi.org/10.3892/mmr.2015.3803
Copy and paste a formatted citation
x
Spandidos Publications style
Liu G, Liu C and Zhang XN: Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats. Mol Med Rep 12: 3297-3308, 2015.
APA
Liu, G., Liu, C., & Zhang, X. (2015). Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats. Molecular Medicine Reports, 12, 3297-3308. https://doi.org/10.3892/mmr.2015.3803
MLA
Liu, G., Liu, C., Zhang, X."Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats". Molecular Medicine Reports 12.3 (2015): 3297-3308.
Chicago
Liu, G., Liu, C., Zhang, X."Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats". Molecular Medicine Reports 12, no. 3 (2015): 3297-3308. https://doi.org/10.3892/mmr.2015.3803
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