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Review Open Access

Epigenetic alterations in gastric cancer (Review)

  • Authors:
    • Du-Guan Fu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3223-3230
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    Published online on: May 22, 2015
       https://doi.org/10.3892/mmr.2015.3816
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Abstract

Gastric cancer is one of the most common types of cancer and the second most common cause of cancer-related mortality worldwide. An increasing number of recent studies have confirmed that gastric cancer is a multistage pathological state that arises from environmental factors; dietary factors in particulary are considered to play an important role in the etiology of gastric cancer. Improper dietary habits are one of the primary concerns as they influence key molecular events associated with the onset of gastric carcinogenesis. In the field of genetics, anticancer research has mainly focused on the various genetic markers and genetic molecular mechanisms responsible for the development of this of this disease. Some of this research has proven to be very fruitful, providing insight into the possible mechamisms repsonsible for this disease and into possible treatment modalities. However, the mortality rate associated with gastric cancer remains relatively high. Thus, epigenetics has become a hot topic for research, whereby genetic markers are bypassed and this research is directed towards reversible epigenetic events, such as methylation and histone modifications that play a crucial role in carcinogenesis. The present review focuses on the epigenetic events which play an important role in the development and progression of this deadly disease, gastric cancer.
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1 

Ushijima T and Sasako M: Focus on gastric cancer. Cancer Cell. 5:121–125. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Smith MG, Hold GL, Tahara E and El-Omar EM: Cellular and molecular aspects of gastric cancer. World J Gastroenterol. 12:2979–2990. 2006.PubMed/NCBI

3 

Tahara E: Genetic pathways of two types of gastric cancer. IARC Sci Publ. 157:327–349. 2004.PubMed/NCBI

4 

Lee JH, Abraham SC, Kim HS, Nam JH, Choi C, Lee MC, Park CS, Juhng SW, Rashid A, Hamilton SR, et al: Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma. Am J Pathol. 161:611–618. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Park WS, Oh RR, Park JY, Lee SH, Shin MS, Kim YS, Kim SY, Lee HK, Kim PJ, Oh ST, et al: Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer. Cancer Res. 59:4257–4260. 1999.PubMed/NCBI

6 

Maesawa C, Tamura G, Suzuki Y, Ogasawara S, Sakata K, Kashiwaba M and Satodate R: The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma. J Pathol. 176:249–258. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Becker KF, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR and Höfler H: E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res. 54:3845–3852. 1994.PubMed/NCBI

8 

Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, et al: Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell. 109:113–124. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Hirst M and Marra MA: Epigenetics and human disease. Int J Biochem Cell Biol. 41:136–146. 2009. View Article : Google Scholar

10 

Panani AD: Cytogenetic and molecular aspects of gastric cancer: Clinical implications. Cancer Lett. 266:99–115. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Waddington CH: An Introduction to Modern Genetics. Allen & Unwin; London: 1939

12 

Riggs AD, Martienssen RA and Ruso VEA: Epigenetic mechanisms of gene regulation. Cold Spring Harbor Laboratory Press; ISBN: 0-87969-490-41996

13 

Mulero-Navarro S and Esteller M: Epigenetic biomarkers for human cancer: The time is now. Crit Rev Oncol Hematol. 68:1–11. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Khan FA and Shukla AN: Pathogenesis and treatment of gastric carcinoma: 'an up-date with brief review'. J Cancer Res Ther. 2:196–199. 2006. View Article : Google Scholar

15 

Nitti D, Mocellin S, Marchet A, Pilati P and Lise M: Recent advances in conventional and molecular prognostic factors for gastric carcinoma. Surg Oncol Clin N Am. 17:467–483. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Fan CY: Epigenetic alterations in head and neck cancer: Prevalence, clinical significance, and implications. Curr Oncol Rep. 6:152–161. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Tischoff I, Wittekind C and Tannapfel A: Role of epigenetic alterations in cholangiocarcinoma. J Hepatobiliary Pancreat Surg. 13:274–279. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Robertson KD: DNA methylation and human disease. Nat Rev Genet. 6:597–610. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Bird AP: CpG-rich islands and the function of DNA methylation. Nature. 321:209–213. 1986. View Article : Google Scholar : PubMed/NCBI

20 

Nakajima T, Enomoto S and Ushijima T: DNA methylation: A marker for carcinogen exposure and cancer risk. Environ Health Prev Med. 13:8–15. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Chen CZ: MicroRNAs as oncogenes and tumor suppressors. N Engl J Med. 353:1768–1771. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Hinshelwood RA and Clark SJ: Breast cancer epigenetics: Normal human mammary epithelial cells as a model system. J Mol Med Berl. 86:1315–1328. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Jones PA and Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet. 3:415–428. 2002.PubMed/NCBI

25 

Karpf AR and Jones DA: Reactivating the expression of methylation silenced genes in human cancer. Oncogene. 21:5496–5503. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Sparmann A and van Lohuizen M: Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer. 6:846–856. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Lund AH and van Lohuizen M: Polycomb complexes and silencing mechanisms. Curr Opin Cell Biol. 16:239–246. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Thacker J: The RAD51 gene family, genetic instability and cancer. Cancer Lett. 219:125–135. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Kim K, Park U, Wang J, Lee J, Park S, Kim S, Choi D, Kim C and Park J: Gene profiling of colonic serrated adenomas by using oligonucleotide microarray. Int J Colorectal Dis. 23:569–580. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Mancino M, Strizzi L, Wechselberger C, Watanabe K, Gonzales M, Hamada S, Normanno N, Salomon DS and Bianco C: Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells. J Cell Physiol. 215–203. 2008.

31 

Forn M, Díez-Villanueva A, Merlos-Suárez A, Muñoz M, Lois S, Carriò E, Jordà M, Bigas A, Batlle E and Peinado MA: Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression. PLoS One. 10:e01232632015. View Article : Google Scholar : PubMed/NCBI

32 

Bae JH, Kim JG, Heo K, Yang K, Kim TO and Yi JM: Identification of radiation-induced aberrant hypomethylation in colon cancer. BMC Genomics. 16:562015. View Article : Google Scholar : PubMed/NCBI

33 

Ng JM and Yu J: Promoter hypermethylation of tumour suppressor genes as potential biomarkers in colorectal cancer. Int J Mol Sci. 16:2472–2496. 2015. View Article : Google Scholar : PubMed/NCBI

34 

An C, Choi IS, Yao JC, Worah S, Xie K, Mansfield PF, Ajani JA, Rashid A, Hamilton SR and Wu TT: Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma. Clin Cancer Res. 11:656–663. 2005.PubMed/NCBI

35 

Song SH, Jong HS, Choi HH, Kang SH, Ryu MH, Kim NK, Kim WH and Bang YJ: Methylation of specific CpG sites in the promoter region could significantly down-regulate p16(INK4a) expression in gastric adenocarcinoma. Int J Cancer. 87:236–240. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Guimarães AC, Lima EM, Khayat AS, Girão Faria MH, Barem Rabenhorst SH, Pitombeira MV, Assumpção PP, de Oliveira Bahia M, Lima de Lima PD, de Arruda Cardoso Smith M, et al: Interrelationships among chromosome aneuploidy, promoter hypermethylation, and protein expression of the CDKN2A gene in individuals from northern Brazil with gastric adenocarcinoma. Cancer Genet Cytogenet. 179:45–51. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Lee JH, Park SJ, Abraham SC, Seo JS, Nam JH, Choi C, Juhng SW, Rashid A, Hamilton SR and Wu TT: Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas. Oncogene. 23:4646–4654. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, et al: Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res. 59:1090–1095. 1999.PubMed/NCBI

39 

Leung SY, Yuen ST, Chung LP, Chu KM, Chan AS and Ho JC: hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res. 59:159–164. 1999.PubMed/NCBI

40 

Jung HY, Jung KC, Shim YH, Ro JY and Kang GH: Methylation of the hMLH1 promoter in multiple gastric carcinomas with microsatellite instability. Pathol Int. 51:445–451. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Zhang YJ, Chen Y, Ahsan H, Lunn RM, Lee PH, Chen CJ and Santella RM: Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma. Int J Cancer. 103:440–444. 2003. View Article : Google Scholar

42 

Zazula M, Ferreira AM, Czopek JP, Kolodziejczyk P, Sinczak-Kuta A, Klimkowska A, Wojcik P, Okon K, Bialas M, Kulig J, et al: CDH1 gene promoter hypermethylation in gastric cancer: Relationship to Goseki grading, microsatellite instability status, and EBV invasion. Diagn Mol Pathol. 15:24–29. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Graziano F, Arduini F, Ruzzo A, Bearzi I, Humar B, More H, Silva R, Muretto P, Guilford P, Testa E, et al: Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. Clin Cancer Res. 10:2784–2789. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Liu WT, Jiao HL, Yang YL, Wang D and Zhang WM: Correlation of E-cadherin hypermethylation to tumorigenesis and development of gastric cancer. Ai Zheng. 26:1199–1203. 2007.In Chinese. PubMed/NCBI

45 

Chan AO: E-cadherin in gastric cancer. World J Gastroenterol. 12:199–203. 2006.PubMed/NCBI

46 

Chan AO, Lam SK, Wong BC, Wong WM, Yuen MF, Yeung YH, Hui WM, Rashid A and Kwong YL: Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut. 52:502–506. 2003. View Article : Google Scholar : PubMed/NCBI

47 

Terrés AM, Pajares JM, O'Toole D, Ahern S and Kelleher D: H. pylori infection is associated with downregulation of E-cadherin, a molecule involved in epithelial cell adhesion and proliferation control. J Clin Pathol. 51:410–412. 1998. View Article : Google Scholar

48 

Miotto E, Sabbioni S, Veronese A, Calin GA, Gullini S, Liboni A, Gramantieri L, Bolondi L, Ferrazzi E, Gafà R, et al: Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer. Cancer Res. 64:8156–8159. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Chan AW, Chan MW, Lee TL, Ng EK, Leung WK, Lau JY, Tong JH, Chan FK and To KF: Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer. Oncol Rep. 13:937–941. 2005.PubMed/NCBI

50 

Byun DS, Lee MG, Chae KS, Ryu BG and Chi SG: Frequent epigenetic inactivation of RASSF1A by aberrant promoter hypermethylation in human gastric adenocarcinoma. Cancer Res. 61:7034–7038. 2001.PubMed/NCBI

51 

Byun DS, Cho K, Ryu BK, Lee MG, Kang MJ, Kim HR and Chi SG: Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas. Cancer Res. 63:7068–7075. 2003.PubMed/NCBI

52 

Jee CD, Lee HS, Bae SI, Yang HK, Lee YM, Rho MS and Kim WH: Loss of caspase-1 gene expression in human gastric carcinomas and cell lines. Int J Oncol. 26:1265–1271. 2005.PubMed/NCBI

53 

Jung Y, Park J, Bang YJ and Kim TY: Gene silencing of TSPYL5 mediated by aberrant promoter methylation in gastric cancers. Lab Invest. 88:153–160. 2008. View Article : Google Scholar

54 

Lee JH, Byun DS, Lee MG, Ryu BK, Kang MJ, Chae KS, Lee KY, Kim HJ, Park H and Chi SG: Frequent epigenetic inactivation of hSRBC in gastric cancer and its implication in attenuated p53 response to stresses. Int J Cancer. 122:1573–1584. 2008. View Article : Google Scholar

55 

Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, et al: Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. Carcinogenesis. 28:2459–2466. 2007. View Article : Google Scholar : PubMed/NCBI

56 

Cheng YY, Yu J, Wong YP, Man EP, To KF, Jin VX, Li J, Tao Q, Sung JJ, Chan FK, et al: Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer. Br J Cancer. 97:895–901. 2007.PubMed/NCBI

57 

Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, et al: Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene. 26:4699–4713. 2007. View Article : Google Scholar : PubMed/NCBI

58 

Ebert MP, Yu J, Hoffmann J, Rocco A, Röcken C, Kahmann S, Müller O, Korc M, Sung JJ and Malfertheiner P: Loss of beta-catenin expression in metastatic gastric cancer. J Clin Oncol. 21:1708–1714. 2003. View Article : Google Scholar : PubMed/NCBI

59 

Takada H, Imoto I, Tsuda H, Nakanishi Y, Sakakura C, Mitsufuji S, Hirohashi S and Inazawa J: Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis. Oncogene. 25:6554–6562. 2006. View Article : Google Scholar : PubMed/NCBI

60 

Oshimo Y, Kuraoka K, Nakayama H, Kitadai Y, Yoshida K, Chayama K and Yasui W: Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma. Int J Cancer. 112:1003–1009. 2004. View Article : Google Scholar : PubMed/NCBI

61 

Choi MC, Jong HS, Kim TY, Song SH, Lee DS, Lee JW, Kim TY, Kim NK and Bang YJ: AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity. Oncogene. 23:7095–7103. 2004. View Article : Google Scholar : PubMed/NCBI

62 

Oshimo Y, Oue N, Mitani Y, Nakayama H, Kitadai Y, Yoshida K, Chayama K and Yasui W: Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma. Int J Cancer. 110:212–218. 2004. View Article : Google Scholar : PubMed/NCBI

63 

Yamamichi N, Inada K, Ichinose M, Yamamichi-Nishina M, Mizutani T, Watanabe H, Shiogama K, Fujishiro M, Okazaki T, Yahagi N, et al: Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state. Cancer Res. 67:10727–10735. 2007. View Article : Google Scholar : PubMed/NCBI

64 

Hamai Y, Oue N, Mitani Y, Nakayama H, Ito R, Matsusaki K, Yoshida K, Toge T and Yasui W: DNA hypermethylation and histone hypoacetylation of the HLTF gene are associated with reduced expression in gastric carcinoma. Cancer Sci. 94:692–698. 2003. View Article : Google Scholar : PubMed/NCBI

65 

Kim TY, Lee HJ, Hwang KS, Lee M, Kim JW, Bang YJ and Kang GH: Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma. Lab Invest. 84:479–484. 2004. View Article : Google Scholar : PubMed/NCBI

66 

Hayashi K, Yokozaki H, Goodison S, Oue N, Suzuki T, Lotan R, Yasui W and Tahara E: Inactivation of retinoic acid receptor beta by promoter CpG hypermethylation in gastric cancer. Differentiation. 68:13–21. 2001. View Article : Google Scholar : PubMed/NCBI

67 

Oue N, Matsumura S, Nakayama H, Kitadai Y, Taniyama K, Matsusaki K and Yasui W: Reduced expression of the TSP1 gene and its association with promoter hypermethylation in gastric carcinoma. Oncology. 64:423–429. 2003. View Article : Google Scholar : PubMed/NCBI

68 

Kim TY, Jong HS, Song SH, Dimtchev A, Jeong SJ, Lee JW, Kim TY, Kim NK, Jung M and Bang YJ: Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. Oncogene. 22:3943–3951. 2003. View Article : Google Scholar : PubMed/NCBI

69 

Yu J, Leung WK, Lee TL, Tse PC, To KF and Sung JJ: Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma. Int J Oncol. 22:1025–1031. 2003.PubMed/NCBI

70 

de Maat MF, van de Velde CJ, Umetani N, de Heer P, Putter H, van Hoesel AQ, Meijer GA, van Grieken NC, Kuppen PJ, Bilchik AJ, et al: Epigenetic silencing of cyclooxygenase-2 affects clinical outcome in gastric cancer. J Clin Oncol. 25:4887–4894. 2007. View Article : Google Scholar : PubMed/NCBI

71 

Poplawski T, Tomaszewska K, Galicki M, Morawiec Z and Blasiak J: Promoter methylation of cancer-related genes in gastric carcinoma. Exp Oncol. 30:112–116. 2008.PubMed/NCBI

72 

Lee TL, Leung WK, Chan MW, Ng EK, Tong JH, Lo KW, Chung SC, Sung JJ and To KF: Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma. Clin Cancer Res. 8:1761–1766. 2002.PubMed/NCBI

73 

Kang GH, Lee S, Kim JS and Jung HY: Profile of aberrant CpG island methylation along multistep gastric carcinogenesis. Lab Invest. 83:519–526. 2003. View Article : Google Scholar : PubMed/NCBI

74 

Oue N, Motoshita J, Yokozaki H, Hayashi K, Tahara E, Taniyama K, Matsusaki K and Yasui W: Distinct promoter hypermethylation of p16INK4a, CDH1, and RAR-beta in intestinal, diffuse-adherent, and diffuse-scattered type gastric carcinomas. J Pathol. 198:55–59. 2002. View Article : Google Scholar : PubMed/NCBI

75 

Honda T, Tamura G, Waki T, Kawata S, Terashima M, Nishizuka S and Motoyama T: Demethylation of MAGE promoters during gastric cancer progression. Br J Cancer. 90:838–843. 2004. View Article : Google Scholar : PubMed/NCBI

76 

Yanagawa N, Tamura G, Honda T, Endoh M, Nishizuka S and Motoyama T: Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines. Clin Cancer Res. 10:2447–2451. 2004. View Article : Google Scholar : PubMed/NCBI

77 

Lima EM, Leal MF, Burbano RR, Khayat AS, Assumpção PP, Bello MJ, Rey JA, Smith MA and Casartelli C: Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer. Braz J Med Biol Res. 41:539–543. 2008. View Article : Google Scholar : PubMed/NCBI

78 

Park YS, Jin MY, Kim YJ, Yook JH, Kim BS and Jang SJ: The global histone modification pattern correlates with cancer recurrence and overall survival in gastric adenocarcinoma. Ann Surg Oncol. 15:1968–1976. 2008. View Article : Google Scholar : PubMed/NCBI

79 

Heard E, Rougeulle C, Arnaud D, Avner P, Allis CD and Spector DL: Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation. Cell. 107:727–738. 2001. View Article : Google Scholar : PubMed/NCBI

80 

Mermoud JE, Popova B, Peters AH, Jenuwein T and Brockdorff N: Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation. Curr Biol. 12:247–251. 2002. View Article : Google Scholar : PubMed/NCBI

81 

Nguyen CT, Weisenberger DJ, Velicescu M, Gonzales FA, Lin JC, Liang G and Jones PA: Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′-deoxycytidine. Cancer Res. 62:6456–6461. 2002.PubMed/NCBI

82 

Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D and Jenuwein T: A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 18:1251–1262. 2004. View Article : Google Scholar : PubMed/NCBI

83 

Kondo Y, Shen L and Issa JP: Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol. 23:206–215. 2003. View Article : Google Scholar :

84 

Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, et al: PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer. Clin Cancer Res. 13:4786–4794. 2007. View Article : Google Scholar : PubMed/NCBI

85 

Ono S, Oue N, Kuniyasu H, Suzuki T, Ito R, Matsusaki K, Ishikawa T, Tahara E and Yasui W: Acetylated histone H4 is reduced in human gastric adenomas and carcinomas. J Exp Clin Cancer Res. 21:377–382. 2002.PubMed/NCBI

86 

Mitani Y, Oue N, Hamai Y, Aung PP, Matsumura S, Nakayama H, Kamata N and Yasui W: Histone H3 acetylation is associated with reduced p21(WAF1/CIP1) expression by gastric carcinoma. J Pathol. 205:65–73. 2005. View Article : Google Scholar

87 

Xia G, Schneider-Stock R, Diestel A, Habold C, Krueger S, Roessner A, Naumann M and Lendeckel U: Helicobacter pylori regulates p21(WAF1) by histone H4 acetylation. Biochem Biophys Res Commun. 369:526–531. 2008. View Article : Google Scholar : PubMed/NCBI

88 

Yi Kim D, Kyoon Joo J, Kyu Park Y, Yeob Ryu S, Soo Kim H, Kyun Noh B, Hwa Lee K and Hyuk Lee J: E-cadherin expression in early gastric carcinoma and correlation with lymph node metastasis. J Surg Oncol. 96:429–435. 2007. View Article : Google Scholar : PubMed/NCBI

89 

Rich S, Ganz R and Levy PS: Comparative actions of hydralazine, nifedipine and amrinone in primary pulmonary hypertension. Am J Cardiol. 52:1104–1107. 1983. View Article : Google Scholar : PubMed/NCBI

90 

Windle J, Prystowsky EN, Miles WM and Heger JJ: Pharmacokinetic and electrophysiologic interactions of amiodarone and procainamide. Clin Pharmacol Ther. 41:603–610. 1987. View Article : Google Scholar : PubMed/NCBI

91 

Strolin Benedetti M, Rumigny JF and Dostert P: Mechanisms of action and biochemical toxicology of valproic acid. Encephale. 10:177–188. 1984.In French.

92 

Kaminskas E, Farrell A, Abraham S, Baird A, Hsieh LS, Lee SL, Leighton JK, Patel H, Rahman A, Sridhara R, et al: FDA: Approval summary: Azacitidine for treatment of myelodysplastic syndrome subtypes. Clin Cancer Res. 11:3604–3608. 2005. View Article : Google Scholar : PubMed/NCBI

93 

Issa JP, Gharibyan V, Cortes J, Jelinek J, Morris G, Verstovsek S, Talpaz M, Garcia-Manero G and Kantarjian HM: Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. J Clin Oncol. 23:3948–3956. 2005. View Article : Google Scholar : PubMed/NCBI

94 

Zambrano P, Segura-Pacheco B, Perez-Cardenas E, Cetina L, Revilla-Vazquez A, Taja-Chayeb L, Chavez-Blanco A, Angeles E, Cabrera G, Sandoval K, et al: A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes. BMC Cancer. 5:442005. View Article : Google Scholar : PubMed/NCBI

95 

Zhang X, Yashiro M, Ren J and Hirakawa K: Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines. Oncol Rep. 16:563–568. 2006.PubMed/NCBI

96 

Riester D, Hildmann C and Schwienhorst A: Histone deacetylase inhibitors - turning epigenic mechanisms of gene regulation into tools of therapeutic intervention in malignant and other diseases. Appl Microbiol Biotechnol. 75:499–514. 2007. View Article : Google Scholar : PubMed/NCBI

97 

Ji M, Lee EJ, Kim KB, Kim Y, Sung R, Lee SJ, Kim DS and Park SM: HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. Oncol Rep. 33:2299–2308. 2015.PubMed/NCBI

98 

Kang Y, Nian H, Rajendran P, Kim E, Dashwood WM, Pinto JT, Boardman LA, Thibodeau SN, Limburg PJ, Löhr CV, et al: HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. Cell Death Dis. 5:e14762014. View Article : Google Scholar : PubMed/NCBI

99 

Satoh A, Toyota M, Itoh F, Sasaki Y, Suzuki H, Ogi K, Kikuchi T, Mita H, Yamashita T, Kojima T, et al: Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer. Cancer Res. 63:8606–8613. 2003.PubMed/NCBI

100 

Koga Y, Kitajima Y, Miyoshi A, Sato K, Sato S and Miyazaki K: The significance of aberrant CHFR methylation for clinical response to microtubule inhibitors in gastric cancer. J Gastroenterol. 41:133–139. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fu D: Epigenetic alterations in gastric cancer (Review). Mol Med Rep 12: 3223-3230, 2015.
APA
Fu, D. (2015). Epigenetic alterations in gastric cancer (Review). Molecular Medicine Reports, 12, 3223-3230. https://doi.org/10.3892/mmr.2015.3816
MLA
Fu, D."Epigenetic alterations in gastric cancer (Review)". Molecular Medicine Reports 12.3 (2015): 3223-3230.
Chicago
Fu, D."Epigenetic alterations in gastric cancer (Review)". Molecular Medicine Reports 12, no. 3 (2015): 3223-3230. https://doi.org/10.3892/mmr.2015.3816
Copy and paste a formatted citation
x
Spandidos Publications style
Fu D: Epigenetic alterations in gastric cancer (Review). Mol Med Rep 12: 3223-3230, 2015.
APA
Fu, D. (2015). Epigenetic alterations in gastric cancer (Review). Molecular Medicine Reports, 12, 3223-3230. https://doi.org/10.3892/mmr.2015.3816
MLA
Fu, D."Epigenetic alterations in gastric cancer (Review)". Molecular Medicine Reports 12.3 (2015): 3223-3230.
Chicago
Fu, D."Epigenetic alterations in gastric cancer (Review)". Molecular Medicine Reports 12, no. 3 (2015): 3223-3230. https://doi.org/10.3892/mmr.2015.3816
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