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Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels

  • Authors:
    • Tao Guo
    • Rui‑Xing Yin
    • Jian Wu
    • Quan‑Zhen Lin
    • Guang‑Yuan Shi
    • Shao‑Wen Shen
    • Jia‑Qi Sun
    • Hui Li
    • Wei‑Xiong Lin
    • De‑Zhai Yan
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Clinical Laboratory of the Affiliated Cancer Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Molecular Biology, Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3285-3296
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    Published online on: May 25, 2015
       https://doi.org/10.3892/mmr.2015.3825
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Abstract

The present study was performed to examine the association of the angiopoietin-like protein 8 (ANGPTL8) rs2278426 single nucleotide polymorphism (SNP) and several environmental factors with serum lipid profiles in the Mulao and Han populations. A total of 879 individuals of the Mulao ethnic group and 865 individuals of the Han Chinese ethnic group were included. The serum apolipoprotein (Apo) B level was higher, however the serum ApoA1 level was lower in the Mulao individuals than in the Han individuals (P<0.05 and P<0.001, respectively). The genotypic and allelic frequencies, and the association with the ANGPTL8 rs2278426 SNP were different between the Mulao and Han populations. The frequency of the A allele was 17.80% in Han individuals and 23.04% in Mulao individuals (P<0.001). The frequencies of GG, GA and AA genotypes were 68.79, 26.82 and 4.39% in the Han population, and 60.64, 32.65 and 6.71% in the Mulao population (P<0.005), respectively. A significant association between the SNP and serum lipid traits was only detected in Han females and not in Han males or in the Mulao population. The subjects with GA/AA genotypes had lower low‑density lipoprotein cholesterol (LDL‑C) and ApoB levels, and higher ApoA1 levels with a higher ApoA1/ApoB ratio than the subjects with the GG genotype in the Han population. Subgroup analyses revealed that the subjects with the GA/AA genotype had lower levels of total cholesterol, LDL‑C and ApoB, and a higher ApoA1/ApoB ratio than the subjects with the GG genotype in Han females (P<0.05‑P<0.001). Serum lipid parameters were also associated with several environmental factors, including dietary patterns, lifestyle, obesity, physical inactivity and hypertension, in the two ethnic groups (P<0.05‑0.001). These findings suggest that there may be an ethnic‑ and gender‑specific association of the rs2278426 SNP and serum lipid parameters.
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Copy and paste a formatted citation
Spandidos Publications style
Guo T, Yin RX, Wu J, Lin QZ, Shi GY, Shen SW, Sun JQ, Li H, Lin WX, Yan DZ, Yan DZ, et al: Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels. Mol Med Rep 12: 3285-3296, 2015.
APA
Guo, T., Yin, R., Wu, J., Lin, Q., Shi, G., Shen, S. ... Yan, D. (2015). Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels. Molecular Medicine Reports, 12, 3285-3296. https://doi.org/10.3892/mmr.2015.3825
MLA
Guo, T., Yin, R., Wu, J., Lin, Q., Shi, G., Shen, S., Sun, J., Li, H., Lin, W., Yan, D."Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels". Molecular Medicine Reports 12.3 (2015): 3285-3296.
Chicago
Guo, T., Yin, R., Wu, J., Lin, Q., Shi, G., Shen, S., Sun, J., Li, H., Lin, W., Yan, D."Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels". Molecular Medicine Reports 12, no. 3 (2015): 3285-3296. https://doi.org/10.3892/mmr.2015.3825
Copy and paste a formatted citation
x
Spandidos Publications style
Guo T, Yin RX, Wu J, Lin QZ, Shi GY, Shen SW, Sun JQ, Li H, Lin WX, Yan DZ, Yan DZ, et al: Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels. Mol Med Rep 12: 3285-3296, 2015.
APA
Guo, T., Yin, R., Wu, J., Lin, Q., Shi, G., Shen, S. ... Yan, D. (2015). Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels. Molecular Medicine Reports, 12, 3285-3296. https://doi.org/10.3892/mmr.2015.3825
MLA
Guo, T., Yin, R., Wu, J., Lin, Q., Shi, G., Shen, S., Sun, J., Li, H., Lin, W., Yan, D."Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels". Molecular Medicine Reports 12.3 (2015): 3285-3296.
Chicago
Guo, T., Yin, R., Wu, J., Lin, Q., Shi, G., Shen, S., Sun, J., Li, H., Lin, W., Yan, D."Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels". Molecular Medicine Reports 12, no. 3 (2015): 3285-3296. https://doi.org/10.3892/mmr.2015.3825
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