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Article Open Access

Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation

  • Authors:
    • Yao‑Dong Li
    • Yi‑Fan Hong
    • Yueerguli Yusufuaji
    • Bao‑Peng Tang
    • Xian‑Hui Zhou
    • Guo‑Jun Xu
    • Jin‑Xin Li
    • Lin Sun
    • Jiang‑Hua Zhang
    • Qiang Xin
    • Jian Xiong
    • Yu‑Tong Ji
    • Yu Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang Uyghur 830011, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3243-3248
    |
    Published online on: May 25, 2015
       https://doi.org/10.3892/mmr.2015.3831
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Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels mediate pacemaker currents in the atrium. The microRNA (miR) families miR-1 and miR-133 regulate the expression of multiple genes involved in myocardial function, including HCN channels. It was hypothesized that age‑dependent changes in HCN2, HCN4, miR‑1 and miR‑133 expression may contribute to age‑associated atrial fibrillation, and therefore the correlation between expression levels, among adult (≤65 years) and aged patients (≥65 years), and sinus rhythm was determined. Right atrial appendage samples were collected from 60 patients undergoing coronary artery bypass grafting. Reverse transcription-quantitative polymerase chain reaction (PCR) and western blot analyses were performed in order to determine target RNA and protein expression levels. Compared with aged patients with sinus rhythm, aged patients with atrial fibrillation exhibited significantly higher HCN2 and HCN4 channel mRNA and protein expression levels (P<0.05), but significantly lower expression levels of miR‑1 and miR‑133 (P<0.05). In addition, aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR‑1 and ‑133 (P<0.05), compared with those of adult patients with sinus rhythm. Expression levels of HCN2 and HCN4 increased with age, and a greater increase was identified in patients with age‑associated atrial fibrillation compared with that in those with aged sinus rhythm. These electrophysiological changes may contribute to the induction of ectopic premature beats that trigger atrial fibrillation.
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1 

Fuster V, Rydén LE, Cannom DS, et al American College of Cardiology; American Heart Association Task Force; European Society of Cardiology Committee for Practice Guidelines; European Heart Rhythm Association; Heart Rhythm Society: ACC/AHA/ESC 2006 guidelines for the management of patients with a trial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 guidelines for the management of patients with atrial fibrillation) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace. 8:651–745. 2006.PubMed/NCBI

2 

Su N, Duan J, Moffat MP and Narayanan N: Age-related changes in electrophysiological responses to muscarinic receptor stimulation in rat myocardium. Can J Physiol Pharmacol. 73:1430–1436. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Dun W, Yagi T, Rosen MR, et al: Calcium and potassium currents in cells from adult and aged canine right atria. Cardiovasc Res. 58:526–534. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Stillitano F, Lonardo G, Giunti G, et al: Chronic atrial fibrillation alters the functional properties of If in the human atrium. J Cardiovasc Electrophysiol. 24:1391–1400. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Biel M, Wahl-Schott C, Michalakis S and Zong X: Hyperpolarization-activated cation channels: from genes to function. Physiol Rev. 89:847–885. 2009. View Article : Google Scholar : PubMed/NCBI

6 

DiFrancesco D: Funny channels in the control of cardiac rhythm and mode of action of selective blockers. Pharmacol Res. 53:399–406. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Ludwig A, Zong X, Jeglitsch M, et al: A family of hyperpolarization-activated mammalian cation channels. Nature. 393:587–591. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Ludwig A, Zong X, Hofmann F and Biel M: Structure and function of cardiac pacemaker channels. Cell Physiol Biochem. 9:179–186. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Porciatti F, Pelzmann B, Cerbai E, et al: The pacemaker current I(f) in single human atrial myocytes and the effect of beta-adrenoceptor and A1-adenosine receptor stimulation. Br J Pharmacol. 122:963–969. 1997. View Article : Google Scholar

10 

Zorn-Pauly K, Schaffer P, Pelzmann B, et al: If in left human atrium: a potential contributor to atrial ectopy. Cardiovasc Res. 64:250–259. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Roubille F and Tardif JC: New therapeutic targets in cardiology: heart failure and arrhythmia: HCN channels. Circulation. 127:1986–1996. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Zicha S, Fernández-Velasco M, Lonardo G, et al: Sinus node dysfunction and hyperpolarization-activated (HCN)channel subunit remodeling in a canine heart failure model. Cardiovasc Res. 66:472–481. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Yeh YH, Burstein B, Qi XY, et al: Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia. Circulation. 119:1576–1585. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Kuwahara K, Saito Y, Ogawa E, et al: The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes. Mol Cell Biol. 21:2085–2097. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Kuwabara Y, Kuwahara K, Takano M, et al: Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts. J Am Heart Assoc. 2:e0001502013. View Article : Google Scholar : PubMed/NCBI

16 

Stieber J, Hofmann F and Ludwig A: Pacemaker channels and sinus node arrhythmia. Trends Cardiovasc Med. 14:23–28. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Semelka M, Gera J and Usman S: Sick sinus syndrome: a review. Am Fam Physician. 87:691–696. 2013.PubMed/NCBI

18 

Li G, Liu E, Liu T, et al: Atrial electrical remodeling in a canine model of sinus node dysfunction. Int J Cardiol. 146:32–36. 2011. View Article : Google Scholar

19 

Teh AW, Kalman JM, Lee G, et al: Electroanatomic remodeling of the pulmonary veins associated with age. Europace. 14:46–51. 2012. View Article : Google Scholar

20 

Tuan TC, Chang SL, Tsao HM, et al: The impact of age on the electroanatomical characteristics and outcome of catheter ablation in patients with atrial fibrillation. J Cardiovasc Electrophysiol. 21:966–972. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Li JY, Wang HJ, Xu B, et al: Hyperpolarization activated cation current (I(f)) in cardiac myocytes from pulmonary vein sleeves in the canine with atrial fibrillation. J Geriatr Cardiol. 9:366–374. 2012.

22 

Lee HJ: Exceptional stories of microRNAs. Exceptional stories of microRNAs. Exp Biol Med (Maywood). 238:339–343. 2013. View Article : Google Scholar

23 

Girmatsion Z, Biliczki P, Bonauer A, et al: Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation. Heart Rhythm. 6:1802–1809. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Callis TE, Deng Z, Chen JF and Wang DZ: Muscling through the microRNA world. Exp Biol Med (Maywood). 233:131–138. 2008. View Article : Google Scholar

25 

Suffredini S, Stillitano F, Comini L, et al: Long-term treatment with ivabradine in post-myocardial infarcted rats counteracts f-channel overexpression. Br J Pharmacol. 165:1457–1466. 2012. View Article : Google Scholar :

26 

Luo X, Lin H, Pan Z, et al: Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J Biol Chem. 283:20045–20052. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Xu GJ, Gan TY, Tang BP, et al: Changes in microRNAs expression are involved in age-related atrial structural remodeling and atrial fibrillation. Chin Med J (Engl). 126:1458–1463. 2013.

28 

Suenari K, Cheng CC, Chen YC, Lin YK, Nakano Y, Kihara Y, Chen SA and Chen YJ: Effects of ivabradine on the pulmonary vein electrical activity and modulation of pacemaker currents and calcium homeostasis. J Cardiovasc Electrophysiol. 23:200–206. 2012. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li YD, Hong YF, Yusufuaji Y, Tang BP, Zhou XH, Xu GJ, Li JX, Sun L, Zhang JH, Xin Q, Xin Q, et al: Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation. Mol Med Rep 12: 3243-3248, 2015.
APA
Li, Y., Hong, Y., Yusufuaji, Y., Tang, B., Zhou, X., Xu, G. ... Zhang, Y. (2015). Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation. Molecular Medicine Reports, 12, 3243-3248. https://doi.org/10.3892/mmr.2015.3831
MLA
Li, Y., Hong, Y., Yusufuaji, Y., Tang, B., Zhou, X., Xu, G., Li, J., Sun, L., Zhang, J., Xin, Q., Xiong, J., Ji, Y., Zhang, Y."Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation". Molecular Medicine Reports 12.3 (2015): 3243-3248.
Chicago
Li, Y., Hong, Y., Yusufuaji, Y., Tang, B., Zhou, X., Xu, G., Li, J., Sun, L., Zhang, J., Xin, Q., Xiong, J., Ji, Y., Zhang, Y."Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation". Molecular Medicine Reports 12, no. 3 (2015): 3243-3248. https://doi.org/10.3892/mmr.2015.3831
Copy and paste a formatted citation
x
Spandidos Publications style
Li YD, Hong YF, Yusufuaji Y, Tang BP, Zhou XH, Xu GJ, Li JX, Sun L, Zhang JH, Xin Q, Xin Q, et al: Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation. Mol Med Rep 12: 3243-3248, 2015.
APA
Li, Y., Hong, Y., Yusufuaji, Y., Tang, B., Zhou, X., Xu, G. ... Zhang, Y. (2015). Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation. Molecular Medicine Reports, 12, 3243-3248. https://doi.org/10.3892/mmr.2015.3831
MLA
Li, Y., Hong, Y., Yusufuaji, Y., Tang, B., Zhou, X., Xu, G., Li, J., Sun, L., Zhang, J., Xin, Q., Xiong, J., Ji, Y., Zhang, Y."Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation". Molecular Medicine Reports 12.3 (2015): 3243-3248.
Chicago
Li, Y., Hong, Y., Yusufuaji, Y., Tang, B., Zhou, X., Xu, G., Li, J., Sun, L., Zhang, J., Xin, Q., Xiong, J., Ji, Y., Zhang, Y."Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation". Molecular Medicine Reports 12, no. 3 (2015): 3243-3248. https://doi.org/10.3892/mmr.2015.3831
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