|
1
|
Siegel R, Ma J, Zou Z and Jemal A: Cancer
statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Beck F, Chawengsaksophak K, Waring P,
Playford RJ and Furness JB: Reprogramming of intestinal
differentiation and intercalary regeneration in Cdx2 mutant mice.
Proc Natl Acad Sci USA. 96:7318–7323. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Olsen AK, Boyd M, Danielsen ET and
Troelsen JT: Current and emerging approaches to define intestinal
epithelium-specific transcriptional networks. Am J Physiol
Gastrointest Liver Physiol. 302:G277–G286. 2012. View Article : Google Scholar
|
|
4
|
Gao N, White P and Kaestner KH:
Establishment of intestinal identity and epithelial-mesenchymal
signaling by Cdx2. Dev Cell. 16:588–599. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Verzi MP, Shin H, He HH, Sulahian R, Meyer
CA, Montgomery RK, Fleet JC, Brown M, Liu XS and Shivdasani RA:
Differentiation-specific histone modifications reveal dynamic
chromatin interactions and partners for the intestinal
transcription factor CDX2. Dev Cell. 19:713–726. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Boyd M, Hansen M, Jensen TG, Perearnau A,
Olsen AK, Bram LL, Bak M, Tommerup N, Olsen J and Troelsen JT:
Genome-wide analysis of CDX2 binding in intestinal epithelial cells
(Caco-2). J Biol Chem. 285:25115–25125. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Suh E, Chen L, Taylor J and Traber PG: A
homeodomain protein related to caudal regulates intestine-specific
gene transcription. Mol Cell Biol. 14:7340–7351. 1994.PubMed/NCBI
|
|
8
|
Troelsen JT, Mitchelmore C, Spodsberg N,
Jensen AM, Norén O and Sjöström H: Regulation of lactase-phlorizin
hydrolase gene expression by the caudal-related homoeodomain
protein Cdx-2. Biochem J. 322:833–838. 1997.PubMed/NCBI
|
|
9
|
Fang R, Santiago NA, Olds LC and Sibley E:
The homeodomain protein Cdx2 regulates lactase gene promoter
activity during enterocyte differentiation. Gastroenterology.
118:115–127. 2000. View Article : Google Scholar
|
|
10
|
Lambert M, Colnot S, Suh E, L'Horset F,
Blin C, Calliot ME, Raymondjean M, Thomasset M, Traber PG and
Perret C: cis-Acting elements and transcription factors involved in
the intestinal specific expression of the rat calbindin-D9K gene:
binding of the intestine-specific transcription factor Cdx-2 to the
TATA box. Eur J Biochem. 236:778–788. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Colnot S, Romagnolo B, Lambert M, Cluzeaud
F, Porteu A, Vandewalle A, Thomasset M, Kahn A and Perret C:
Intestinal expression of the calbindin-D9K gene in transgenic mice.
Requirement for a Cdx2-binding site in a distal activator region. J
Biol Chem. 273:31939–31946. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Lee SY, Nagy BP, Brooks AR, Wang DM,
Paulweber B and Levy-Wilson B: Members of the caudal family of
home-odomain proteins repress transcription from the human
apolipoprotein B promoter in intestinal cells. J Biol Chem.
271:707–718. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Sakaguchi T, Gu X, Golden HM, Suh E,
Rhoads DB and Reinecker HC: Cloning of the human claudin-2
5′-flanking region revealed a TATA-less promoter with conserved
binding sites in mouse and human for caudal-related homeodomain
proteins and hepatocyte nuclear factor-1alpha. J Biol Chem.
277:21361–21370. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Yamamoto H, Bai YQ and Yuasa Y:
Homeodomain protein CDX2 regulates goblet-specific MUC2 gene
expression. Biochem Biophys Res Commun. 300:813–818. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Mesquita P, Jonckheere N, Almeida R,
Ducourouble MP, Serpa J, Silva E, Pigny P, Silva FS, Reis C,
Silberg D, Van Seuningen I and David L: Human MUC2 mucin gene is
transcriptionally regulated by Cdx homeodomain proteins in
gastrointestinal carcinoma cell lines. J Biol Chem.
278:51549–51556. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Bonhomme C, Duluc I, Martin E,
Chawengsaksophak K, Chenard MP, Kedinger M, Beck F and Domon-Dell
C: The Cdx2 homeobox gene has a tumour suppressor function in the
distal colon in addition to a homeotic role during gut development.
Gut. 52:1465–1471. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Aoki K, Tamai Y, Horiike S, Oshima M and
Taketo MM: Colonic polyposis caused by mTOR-mediated chromosomal
instability in Apc+/Delta716 Cdx2+/-compound mutant mice. Nat
Genet. 35:323–330. 2003. View
Article : Google Scholar : PubMed/NCBI
|
|
18
|
Bakaris S, Cetinkaya A, Ezberci F and
Ekerbicer H: Expression of homeodomain protein CDX2 in colorectal
adenoma and adenocarcinoma. Histol Histopathol. 23:1043–1047.
2008.PubMed/NCBI
|
|
19
|
Choi BJ, Kim CJ, Cho YG, Song JH, Kim SY,
Nam SW, Lee SH, Yoo NJ, Lee JY and Park WS: Altered expression of
CDX2 in colorectal cancers. APMIS. 114:50–54. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Hong KD, Lee D, Lee Y, Lee SI and Moon HY:
Reduced CDX2 expression predicts poor overall survival in patients
with colorectal cancer. Am Surg. 79:353–360. 2013.PubMed/NCBI
|
|
21
|
Brabletz T, Spaderna S, Kolb J, Hlubek F,
Faller G, Bruns CJ, Jung A, Nentwich J, Duluc I, Domon-Dell C,
Kirchner T and Freund JN: Down-regulation of the homeodomain factor
cdx2 in colorectal cancer by collagen type I: an active role for
the tumor environment in malignant tumor progression. Cancer Res.
64:6973–6977. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
American Psychological Association
Committee on Animal Research Ethics: Guidelines for ethical conduct
in the care and use of nonhuman animals in research. American
Psychological Association; Washington, DC, USA: 2012
|
|
23
|
National Research Council (US) Committee
for the Update of the Guide for the Care and Use of Laboratory
Animals: Guide for the Care and Use of Laboratory Animals. 8th
edition. The National Academies Collection: Reports funded by
National Institutes of Health; Washington, DC, USA: 2011
|
|
24
|
Hammond JB and Kruger NJ: The bradford
method for protein quantitation. Methods Mol Biol. 3:25–32.
1988.PubMed/NCBI
|
|
25
|
Kawai H, Tomii K, Toyooka S, Yano M,
Murakami M, Tsukuda K and Shimizu N: Promoter methylamine down
regulates CDX2 expression in colorectal carcinomas. Oncol Rep.
13:547–551. 2005.PubMed/NCBI
|
|
26
|
Keller MS, Ezaki T, Guo RJ and Lynch JP:
Cdxl or Cdx2 expression activates E-cadherin-ediated cell-cell
adhesion and compaction in human colo 205 cells. Am J Physiol
Castrointest Liver Physiol. 287:G104–G114. 2004. View Article : Google Scholar
|
|
27
|
Werling RW, Yaziji H, Bacchi CE and Gown
AM: CDX2, a highly sensitive and specific marker of adenocarcinomas
of intestinal origin: an immunohistochemical survey of 476 primary
and metastatic carcinomas. Am J Surg Pathol. 27:303–310. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Zheng J, Sun X, Wang W and Lu S:
Hypoxia-inducible factor-1α modulates the down-regulation of the
homeodomain protein CDX2 in colorectal cancer. Oncol Rep.
24:97–104. 2010.PubMed/NCBI
|
|
29
|
Dang LH, Chen F, Ying C, Chun SY, Knock
SA, Appelman HD and Dang DT: CDX2 has tumorigenic potential in the
human colon cancer cell lines Lovo and SW48. Oncogene.
25:2264–2272. 2006. View Article : Google Scholar
|
|
30
|
Zheng JB, Sun XJ, Li SS, Wang W, Ren HL,
Tian Y, Lu SY and Du JK: Effects of homeodomain protein CDX2
expression on the proliferation and migration of lovo colon cancer
cells. Pathol Oncol Res. 17:743–751. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Gross I, Duluc I, Benameur T, Calon A,
Martin E, Brabletz T, Kedinger M, Domon-Dell C and Freund JN: The
intestine-specific homeobox gene Cdx2 decreases mobility and
antagonizes dissemination of colon cancer cells. Oncogene.
27:107–115. 2008. View Article : Google Scholar
|
|
32
|
Benahmed F, Gross I, Guenot D, Jehan F,
Martin E, Domon-Dell C, Brabletz T, Kedinger M, Freund JN and Duluc
I: The microenvi-ronment controls CDX2 homeobox gene expression in
colorectal cancer cells. Am J Pathol. 170:733–744. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Hanahan D and Weinberg RA: The hallmarks
of cancer. Cell. 100:57–70. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Derbal-Wolfrom L, Pencreach E, Saandi T,
Aprahamian M, Martin E, Greferath R, Tufa E, Choquet P, Lehn JM,
Nicolau C, Duluc I and Freund JN: Increasing the oxygen load by
treatment with myo-inositol trispyrophosphate reduces growth of
colon cancer and modulates the intestine homeobox gene Cdx2.
Oncogene. 32:4313–4318. 2013. View Article : Google Scholar
|
|
35
|
Jiang WG, Sanders AJ, Katoh M, et al:
Tissue invasion and metastasis: Molecular, biological and clinical
perspectives. Semin Cancer Biol. View Article : Google Scholar
|
|
36
|
Murray GI: Matrix metalloproteinasers: a
multifunctional group of molecules. J Pathol. 195:135–137. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Mook OR, Frederiks WM and Van Noorden CJ:
The role of gelatinases in colorectal progression and metastasis.
Biochim Biophys Acta. 1705:69–89. 2004.PubMed/NCBI
|
|
38
|
Li HC, Cao DC, Liu Y, Hou YF, Wu J, Lu JS,
Di GH, Liu G, Li FM, Ou ZL, et al: Prognostic value of matrix
metalloproteinases (MMP-2 and MMP-9) in patients with lymph
nodenegative breast carcinoma. Breast Cancer Res Treat. 88:75–85.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Barbarosos A, Biacchi D, Bolognese A,
Galati G, Izzo L, Risuleo G and Tartaglia E: Molecular
epidemiologic analysis of the levels of metalloproteinases and
cyclooxygenase-2 in colorectal cancer. Supp Tumor. 4:S2062005.
|
|
40
|
Baker EA and Leaper DJ: The plasminogen
activator and matrix metalloproteinase systems in colorectal
cancer: relationship to tumor pathology. Eur J Cancer. 39:981–988.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Bodey B, Bodey B Jr, Siegel SE and Kaiser
HE: Prognostic significance of matrix metalloproteinase expression
in colorectal carcinoma. In vivo (Athens, Greece). 14:659–666.
2000.
|
|
42
|
Curran S, Dundas SR, Buxton J, Leeman MF,
Ramsay R and Murray GI: Murray matrix metalloproteinase/tissue
inhibitors of matrix metalloproteinase phenotype identifies poor
prognosis colorectal cancers. Clinic Can Res. 10:8229–8234. 2004.
View Article : Google Scholar
|
|
43
|
Pesta M, Holubec L Jr, Topolcan O, Cerna
M, Rupert K, Holubec LS, Treska V, Kormunda S, Elgrova L, Finek J
and Cerny R: Quantitative estimation of matrix metalloproteinases 2
and 7 (MMP-2, MMP-7) and tissue inhibitors of matrix
metal-loproteinases 1 and 2 (TIMP-1, TIMP-2) in colorectal
carcinoma tissue samples. Anticancer Res. 25:3387–3391.
2005.PubMed/NCBI
|
