|
1
|
Cherubini A, Ruggiero C, Morand C, et al:
Dietary antioxidants as potential pharmacological agents for
ischemic stroke. Curr Med Chem. 15:1236–1248. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Harwood M, Danielewska-Nikiel B,
Borzelleca JF, Flamm GW, Williams GM and Lines TC: A critical
review of the data related to the safety of quercetin and lack of
evidence of in vivo toxicity, including lack of
genotoxic/carcinogenic properties. Food Chem Toxicol. 45:2179–2205.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Lee JC, Kim J, Park JK, Chung GH and Jang
YS: The antioxidant, rather than prooxidant, activities of
quercetin on normal cells: Quercetin protects mouse thymocytes from
glucose oxidase-mediated apoptosis. Exp Cell Res. 291:386–397.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Lapi D, Vagnani S, Pignataro G, esposito
E, Paterni M and Colantuoni A: Protective effects of Quercetin on
Rat Pial micro-vascular changes during transient bilateral common
carotid artery occlusion and reperfusion. Front Physiol.
3:322012.
|
|
5
|
Ghosh A, Sarkar S, Mandal AK and Das N:
Neuroprotective role of nanoencapsulated quercetin in combating
ischemia-reperfusion induced neuronal damage in young and aged
rats. PLoS One. 8:e577352013. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Mattson MP, Duan W, Pedersen WA and
Culmsee C: Neurodegenerative disorders and ischemic brain diseases.
Apoptosis. 6:69–81. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Kowaltowski AJ, Castilho RF and Vercesi
AE: Mitochondrial permeability transition and oxidative stress.
FEBS Lett. 495:12–15. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Kuwana T, Mackey MR, Perkins G, et al:
Bid, Bax and lipids cooperate to form supramolecular openings in
the outer mitochondrial membrane. Cell. 111:331–342. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Lei C, Deng J, Wang B, et al: Reactive
oxygen species scavenger inhibits STAT3 activation after transient
focal cerebral ischemia-reperfusion injury in rats. Anesth Analg.
113:153–159. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Priyadarsini RV and Nagini S: Quercetin
suppresses cytochrome P450 mediated ROS generation and NF kappaB
activation to inhibit the development of 7,12-dimethylbenz a
anthracene (DMBA) induced hamster buccal pouch carcinomas. Free
Radic Res. 46:41–49. 2012. View Article : Google Scholar
|
|
11
|
Yao RQ, Qi DS, Yu HL, Liu J, Yang LH and
Wu XX: Quercetin attenuates cell apoptosis in focal cerebral
ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling
pathway. Neurochem Res. 37:2777–2786. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Mayo LD and Donner DB: A
phosphatidylinositol 3-kinase/Akt pathway promotes translocation of
Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci USA.
98:11598–11603. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Janelidze S, Hu BR, Siesjo P and Siesjo
BK: Alterations of Akt1 (PKBalpha) and p70 (S6K) in transient focal
ischemia. Neurobiol Dis. 8:147–154. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Shibata M, Yamawaki T, Sasaki T, et al:
Upregulation of Akt phosphorylation at the early stage of middle
cerebral artery occlusion in mice. Brain Res. 942:1–10. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Noshita N, Lewen A, Sugawara T and Chan
PH: Evidence of phosphorylation of Akt and neuronal survival after
transient focal cerebral ischemia in mice. J Cereb Blood Flow
Metab. 21:1442–1450. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Xue RL, He JX, Wang N, Yao FZ, Lv JR and
Wu G: Relationship between transmembrane signal transduction
pathway and DNA repair and the mechanism after global cerebral
ischemia-reperfusion in rats. Neurosci Bull. 25:115–121. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Hadley G, Papadakis M and Buchan AM: A
method of inducing global cerebral ischemia. Methods Mol Biol.
1135:111–120. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Geocadin RG, Ghodadra R, Kimura T, et al:
A novel quantitative EEG injury measure of global cerebral
ischemia. Clin Neurophysiol. 111:1779–1787. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Vorhees CV and Williams MT: Morris water
maze: procedures for assessing spatial and related forms of
learning and memory. Nat Protoc. 1:848–858. 2006. View Article : Google Scholar
|
|
20
|
Stackman RW Jr, Lora JC and Williams SB:
Directional responding of C57BL/6J mice in the Morris water maze is
influenced by visual and vestibular cues and is dependent on the
anterior thalamic nuclei. J Neurosci. 32:10211–10225. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Simao F, Matte A, Matte C, et al:
Resveratrol prevents oxidative stress and inhibition of
Na(+)K(+)-ATPase activity induced by transient global cerebral
ischemia in rats. J Nutr Biochem. 22:921–928. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Johansson SE, Larsen SS, Povlsen GK and
Edvinsson L: Early MEK1/2 inhibition after global cerebral ischemia
in rats reduces brain damage and improves outcome by preventing
delayed vasoconstrictor receptor upregulation. PLoS One.
9:e924172014. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Ahmad A, Khan MM, Hoda MN, et al:
Quercetin protects against oxidative stress associated damages in a
rat model of transient focal cerebral ischemia and reperfusion.
Neurochem Res. 36:1360–1371. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Pandey AK, Hazari PP, Patnaik R and Mishra
AK: The role of ASIC1a in neuroprotection elicited by quercetin in
focal cerebral ischemia. Brain Res. 1383:289–299. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Rizk NN, Rafols JA and Dunbar JC: Cerebral
ischemia-induced apoptosis and necrosis in normal and diabetic
rats: effects of insulin and C-peptide. Brain Res. 1096:204–212.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Solaroglu I, Tsubokawa T, Cahill J and
Zhang JH: Anti-apoptotic effect of granulocyte-colony stimulating
factor after focal cerebral ischemia in the rat. Neuroscience.
143:965–974. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Yousuf S, Atif F, Ahmad M, et al:
Resveratrol exerts its neuroprotective effect by modulating
mitochondrial dysfunctions and associated cell death during
cerebral ischemia. Brain Res. 1250:242–253. 2009. View Article : Google Scholar
|
|
28
|
Wang R, Li G, Wang W and Li H: Effect of
compound preparation Tongqiao Jiannao capsules on neural cell
apoptosis and Bcl-2 and Bax protein levels in a rat model of brain
ischemia/reperfusion injury. Neural Regener Res. 3:871–874.
2008.
|
|
29
|
Babu PP, Yoshida Y, Su M, Segura M,
Kawamura S and Yasui N: Immunohistochemical expression of Bcl-2,
Bax and cytochrome c following focal cerebral ischemia and effect
of hypothermia in rat. Neurosci Lett. 291:196–200. 2000. View Article : Google Scholar
|
|
30
|
Wang T, Gu J, Wu PF, et al: Protection by
tetrahydroxystilbene glucoside against cerebral ischemia:
involvement of JNK, SIRT1 and NF-kappaB pathways and inhibition of
intracellular ROS/RNS generation. Free Radic Biol Med. 47:229–240.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wu HW, Li HF, Wu XY, Zhao J and Guo J:
Reactive oxygen species mediate ERK activation through different
Raf-1-dependent signaling pathways following cerebral ischemia.
Neurosci Lett. 432:83–87. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Wang Q, Sun AY, Simonyi A, et al: Ethanol
preconditioning protects against ischemia/reperfusion-induced brain
damage: Role of NADPH oxidase-derived ROS. Free Radic Biol Med.
43:1048–1060. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Liang JM, Xu HY, Zhang XJ, Li X, Zhang HB
and Ge PF: Role of mitochondrial function in the protective effects
of ischaemic postconditioning on ischaemia/reperfusion cerebral
damage. J Int Med Res. 41:618–627. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Zhang L, Zhang ZG, Liu XS, Hozeska-Solgot
A and Chopp M: The PI3K/Akt pathway mediates the neuroprotective
effect of atorvastatin in extending thrombolytic therapy after
embolic stroke in the rat. Arterioscler Thromb Vasc Biol.
27:2470–2475. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Endo H, Nito C, Kamada H, Nishi T and Chan
PH: Activation of the Akt/GSK3beta signaling pathway mediates
survival of vulnerable hippocampal neurons after transient global
cerebral ischemia in rats. J Cereb Blood Flow Metab. 26:1479–1489.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Fang XX, Jiang XL, Han XH, Peng YP and Qiu
YH: Neuroprotection of interleukin-6 against NMDA-induced
neurotoxicity is mediated by JAK/STAT3, MAPK/ERK and PI3K/AKT
signaling pathways. Cell Mol Neurobiol. 33:241–251. 2013.
View Article : Google Scholar
|
|
37
|
Gu R, Liu M, Wang Y, Zhou Y and He H:
Angiopoietin-1 mRNA and Bcl-2 expression following estradiol
treatment in ovariectomized rats with focal cerebral
ischemia/reperfusion injury. Neural Regener Res. 4:780–785.
2009.
|
|
38
|
Kitagawa K: CREB and cAMP response
element-mediated gene expression in the ischemic brain. FEBS J.
274:3210–3217. 2007. View Article : Google Scholar : PubMed/NCBI
|
