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Article

CSN5 silencing reverses sorafenib resistance of human hepatocellular carcinoma HepG2 cells

  • Authors:
    • Haibo Wang
    • Zhengyao Qian
    • Hui Zhao
    • Xibo Zhang
    • Shuqiang Che
    • Hongtao Zhang
    • Haitao Shang
    • Jianheng Bao
    • Chengfei Hao
    • Junjian Liu
    • Zhonglian Li
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Surgery (2), Tianjin Nankai Hospital, Tianjin 300100, P.R. China, Department of Cardiology, Tianjin Hospital, Tianjin 300211, P.R. China, Tianjin Entry‑Exit Inspection and Quarantine Bureau, International Travel Healthcare Center, Tianjin 300456, P.R. China, Department of Nephrology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, P.R. China
  • Pages: 3902-3908
    |
    Published online on: May 29, 2015
       https://doi.org/10.3892/mmr.2015.3871
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Abstract

Hepatocellular carcinoma (HCC) is one of the most common tumor types, and is the third leading cause of cancer mortalities worldwide. A large number of patients with HCC are diagnosed at a late stage when the curative treatment of surgical resection and liver transplantation are no longer applicable. Sorafenib has been proved to improve overall survival in advanced HCC; however, drug resistance is common. The present study reported that the CSN5 is correlated with sorafenib resistance of the HCC cell line HepG2/S. Following silencing of CSN5, resistance to sorafenib was reversed, and multi-drug‑resistance proteins, including as adenosine triphosphate binding cassette (ABC)B1, ABCC2 and ABCG2 as well as CDK6, cyclin D1 and B‑cell lymphoma 2 were downregulated. In addition, it was demonstrated that the integrin beta-1, transforming growth factor‑β1 and nuclear factor‑κB pathways were modified by CSN5.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Qian Z, Zhao H, Zhang X, Che S, Zhang H, Shang H, Bao J, Hao C, Liu J, Liu J, et al: CSN5 silencing reverses sorafenib resistance of human hepatocellular carcinoma HepG2 cells. Mol Med Rep 12: 3902-3908, 2015.
APA
Wang, H., Qian, Z., Zhao, H., Zhang, X., Che, S., Zhang, H. ... Li, Z. (2015). CSN5 silencing reverses sorafenib resistance of human hepatocellular carcinoma HepG2 cells. Molecular Medicine Reports, 12, 3902-3908. https://doi.org/10.3892/mmr.2015.3871
MLA
Wang, H., Qian, Z., Zhao, H., Zhang, X., Che, S., Zhang, H., Shang, H., Bao, J., Hao, C., Liu, J., Li, Z."CSN5 silencing reverses sorafenib resistance of human hepatocellular carcinoma HepG2 cells". Molecular Medicine Reports 12.3 (2015): 3902-3908.
Chicago
Wang, H., Qian, Z., Zhao, H., Zhang, X., Che, S., Zhang, H., Shang, H., Bao, J., Hao, C., Liu, J., Li, Z."CSN5 silencing reverses sorafenib resistance of human hepatocellular carcinoma HepG2 cells". Molecular Medicine Reports 12, no. 3 (2015): 3902-3908. https://doi.org/10.3892/mmr.2015.3871
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Qian Z, Zhao H, Zhang X, Che S, Zhang H, Shang H, Bao J, Hao C, Liu J, Liu J, et al: CSN5 silencing reverses sorafenib resistance of human hepatocellular carcinoma HepG2 cells. Mol Med Rep 12: 3902-3908, 2015.
APA
Wang, H., Qian, Z., Zhao, H., Zhang, X., Che, S., Zhang, H. ... Li, Z. (2015). CSN5 silencing reverses sorafenib resistance of human hepatocellular carcinoma HepG2 cells. Molecular Medicine Reports, 12, 3902-3908. https://doi.org/10.3892/mmr.2015.3871
MLA
Wang, H., Qian, Z., Zhao, H., Zhang, X., Che, S., Zhang, H., Shang, H., Bao, J., Hao, C., Liu, J., Li, Z."CSN5 silencing reverses sorafenib resistance of human hepatocellular carcinoma HepG2 cells". Molecular Medicine Reports 12.3 (2015): 3902-3908.
Chicago
Wang, H., Qian, Z., Zhao, H., Zhang, X., Che, S., Zhang, H., Shang, H., Bao, J., Hao, C., Liu, J., Li, Z."CSN5 silencing reverses sorafenib resistance of human hepatocellular carcinoma HepG2 cells". Molecular Medicine Reports 12, no. 3 (2015): 3902-3908. https://doi.org/10.3892/mmr.2015.3871
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