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Article

Downregulation of microRNA‑210 inhibits osteosarcoma growth in vitro and in vivo

  • Authors:
    • Changjian Liu
    • Xin Tang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
  • Pages: 3674-3680
    |
    Published online on: June 3, 2015
       https://doi.org/10.3892/mmr.2015.3880
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Abstract

MicroRNA‑210 (miR‑210), the master hypoxamir, has various roles in the development of certain cancer types. It has been reported that miR‑210 expression was upregulated in patients with osteosarcoma (OS). However, little is known regarding its role in the development of human OS. In the present study, to explore the feasibility of miR‑210 as an effective therapeutic target, miR‑210 inhibitor was transfected into the osteosarcoma cell line MG‑63 cells, and cell proliferation, colony formation, cycle, apoptosis, migration and invasion were assessed. It was found that miR‑210 downregulation significantly suppressed clonogenicity, migration and invasion, as well as induced cell apoptosis, increased the percentage of cells in G1 phrase and decreased the percentage of cells in S phase in vitro. In addition, the effect of miR‑210 on tumor growth was evaluated in vivo. The results indicated that miR‑210 downregulation significantly suppressed tumor growth in nude mouse models. In conclusion, the findings of the present study suggested that miR‑210 is a potential therapeutic agent for the treatment of OS.
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Copy and paste a formatted citation
Spandidos Publications style
Liu C and Tang X: Downregulation of microRNA‑210 inhibits osteosarcoma growth in vitro and in vivo. Mol Med Rep 12: 3674-3680, 2015.
APA
Liu, C., & Tang, X. (2015). Downregulation of microRNA‑210 inhibits osteosarcoma growth in vitro and in vivo. Molecular Medicine Reports, 12, 3674-3680. https://doi.org/10.3892/mmr.2015.3880
MLA
Liu, C., Tang, X."Downregulation of microRNA‑210 inhibits osteosarcoma growth in vitro and in vivo". Molecular Medicine Reports 12.3 (2015): 3674-3680.
Chicago
Liu, C., Tang, X."Downregulation of microRNA‑210 inhibits osteosarcoma growth in vitro and in vivo". Molecular Medicine Reports 12, no. 3 (2015): 3674-3680. https://doi.org/10.3892/mmr.2015.3880
Copy and paste a formatted citation
x
Spandidos Publications style
Liu C and Tang X: Downregulation of microRNA‑210 inhibits osteosarcoma growth in vitro and in vivo. Mol Med Rep 12: 3674-3680, 2015.
APA
Liu, C., & Tang, X. (2015). Downregulation of microRNA‑210 inhibits osteosarcoma growth in vitro and in vivo. Molecular Medicine Reports, 12, 3674-3680. https://doi.org/10.3892/mmr.2015.3880
MLA
Liu, C., Tang, X."Downregulation of microRNA‑210 inhibits osteosarcoma growth in vitro and in vivo". Molecular Medicine Reports 12.3 (2015): 3674-3680.
Chicago
Liu, C., Tang, X."Downregulation of microRNA‑210 inhibits osteosarcoma growth in vitro and in vivo". Molecular Medicine Reports 12, no. 3 (2015): 3674-3680. https://doi.org/10.3892/mmr.2015.3880
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