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Article

Protective effects of ginsenoside Rg1 on aging Sca‑1+ hematopoietic cells

  • Authors:
    • Yue Zhou
    • Jun Liu
    • Shizhong Cai
    • Dianfeng Liu
    • Rong Jiang
    • Yaping Wang
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 3621-3628
    |
    Published online on: June 3, 2015
       https://doi.org/10.3892/mmr.2015.3884
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Abstract

In adults, bone hematopoietic cells are responsible for the lifelong production of all blood cells. It is affected in aging, with progressive loss of physiological integrity leading to impaired function by cellular intrinsic and extrinsic factors. However, intervention measures, which directly inhibit the aging of hematopoietic cells, remain to be investigated. In the present study, 10 µmol/l ginsenoside Rg1 (Rg1) markedly alleviated the aging phenotypes of Sca‑1+ hematopoietic cells following in vitro exposure. In addition, the protective effects of ginsenoside Rg1 on the aging of Sca‑1+ hematopoietic cells was confirmed using a serial transplantation assay in C57BL/6 mice. The mechanistic investigations revealed that Rg1‑mediated Sca‑1+ hematopoietic cell aging alleviation was linked to a series of characteristic events, including telomere end attrition compensation, telomerase activity reconstitution and the activation of genes involved in p16‑Rb signaling pathways. Based on the above results, it was concluded that ginsenoside Rg1 is a potent agent, which acts on hematopoietic cells to protect them from aging, which has implications for therapeutic approaches in hemopoietic diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou Y, Liu J, Cai S, Liu D, Jiang R and Wang Y: Protective effects of ginsenoside Rg1 on aging Sca‑1+ hematopoietic cells. Mol Med Rep 12: 3621-3628, 2015.
APA
Zhou, Y., Liu, J., Cai, S., Liu, D., Jiang, R., & Wang, Y. (2015). Protective effects of ginsenoside Rg1 on aging Sca‑1+ hematopoietic cells. Molecular Medicine Reports, 12, 3621-3628. https://doi.org/10.3892/mmr.2015.3884
MLA
Zhou, Y., Liu, J., Cai, S., Liu, D., Jiang, R., Wang, Y."Protective effects of ginsenoside Rg1 on aging Sca‑1+ hematopoietic cells". Molecular Medicine Reports 12.3 (2015): 3621-3628.
Chicago
Zhou, Y., Liu, J., Cai, S., Liu, D., Jiang, R., Wang, Y."Protective effects of ginsenoside Rg1 on aging Sca‑1+ hematopoietic cells". Molecular Medicine Reports 12, no. 3 (2015): 3621-3628. https://doi.org/10.3892/mmr.2015.3884
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Y, Liu J, Cai S, Liu D, Jiang R and Wang Y: Protective effects of ginsenoside Rg1 on aging Sca‑1+ hematopoietic cells. Mol Med Rep 12: 3621-3628, 2015.
APA
Zhou, Y., Liu, J., Cai, S., Liu, D., Jiang, R., & Wang, Y. (2015). Protective effects of ginsenoside Rg1 on aging Sca‑1+ hematopoietic cells. Molecular Medicine Reports, 12, 3621-3628. https://doi.org/10.3892/mmr.2015.3884
MLA
Zhou, Y., Liu, J., Cai, S., Liu, D., Jiang, R., Wang, Y."Protective effects of ginsenoside Rg1 on aging Sca‑1+ hematopoietic cells". Molecular Medicine Reports 12.3 (2015): 3621-3628.
Chicago
Zhou, Y., Liu, J., Cai, S., Liu, D., Jiang, R., Wang, Y."Protective effects of ginsenoside Rg1 on aging Sca‑1+ hematopoietic cells". Molecular Medicine Reports 12, no. 3 (2015): 3621-3628. https://doi.org/10.3892/mmr.2015.3884
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