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Article Open Access

Recombinant LH supplementation during IVF cycles with a GnRH-antagonist in estimated poor responders: A cross-matched pilot investigation of the optimal daily dose and timing

  • Authors:
    • Salvatore Gizzo
    • Alessandra Andrisani
    • Marco Noventa
    • Serena Manfè
    • Alessandra Oliva
    • Michele Gangemi
    • Giovanni Battista Nardelli
    • Guido Ambrosini
  • View Affiliations / Copyright

    Affiliations: Department of Women's and Children's Health, Assisted Reproductive Unit of the Gynecological and Obstetrics Clinic, University of Padua, I-35128 Padua, Italy
    Copyright: © Gizzo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 4219-4229
    |
    Published online on: June 9, 2015
       https://doi.org/10.3892/mmr.2015.3904
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Abstract

Although it is widely accepted that patients, who are considered poor responders to in vitro fertilization (IVF) benefit from recombinant luteinizing hormone (rLH) supplementation during an in vitro fertilization cycle, particularly when gonadotropin‑releasing hormone (GnRH)‑antagonist (ant) treatment is used the optimal administration timing and daily dose of rLH remains to be elucidated. The aim of the present study was to investigate the optimal timing of rLH‑supplementation to improve ovarian response, embryo quality, endometrial thickness and pregnancy rate in infertile, estimated poor responders to IVF, undergoing GnRH‑ant treatment. In addition, the present study aimed to evaluate the optimal daily dose to achieve the same outcomes. A prospective‑randomized‑cross‑matched investigation was performed on 40 patients undergoing a GnRH‑ant‑treatment‑cycle The patients were randomly assigned to either group A (rLH‑75 IU/day) or group B (rLH‑150 IU/day) and further randomized into subgroup A1/B1, in which rLH was administered at recombinant follicle stimulating hormone (rFSH) administration, and subgroup A2/B2, in which rLH was administered at GnRH‑ant administration. Patients who did not become pregnant during the first cycle (35 patients), were treated a second time, cross‑matched for groups and subgroups. Improved ovarian response, embryo quality and pregnancy rate were achieved by administering rLH at 150 IU/day, starting from GnRH‑ant administration, independently from the total rLH dose administered. Improved endometrial thickness at oocyte retrieval day was achieved by administering rLH at 150 IU from the start of rFSH administration. These data led to the hypothesis that ovarian responses are affected by the timing of administration more than the total‑dose of rLH. The optimal window to administer rLH appears to be the mid‑to‑late follicular phase, despite the fact that rLH‑supplementation in the early‑follicular phase appeared to increase endometrial thickness and to enhance its morphology. Standardization of the optimal daily dose and supplementation timing of rLH may resolve the debate regarding its efficacy in increasing the number of pregnancies and neonatal survival rates.
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1 

Qiao J, Wang ZB, Feng HL, Miao YL, Wang Q, Yu Y, et al: The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects. Mol Aspects Med. 38:54–85. 2014. View Article : Google Scholar

2 

Gizzo S, Andrisani A, Esposito F, Oliva A, Zicchina C, Capuzzo D, et al: Ovarian reserve test: An impartial means to resolve the mismatch between chronological and biological age in the assessment of female reproductive chances. Reprod Sci. 21:632–639. 2014. View Article : Google Scholar

3 

Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G and Gianaroli L: ESHRE working group on poor ovarian response definition. ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 26:1616–1624. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Patrelli TS, Gizzo S, Sianesi N, Levati L, Pezzuto A, Ferrari B, et al: Anti-Müllerian hormone serum values and ovarian reserve: can it predict a decrease in fertility after ovarian stimulation by ART cycles? PLoS One. 7:e445712012. View Article : Google Scholar

5 

Sunkara SK, Coomarasamy A, Faris R, Braude P and Khalaf Y: Long gonadotropin-releasing hormone agonist vs. short agonist vs. antagonist regimens in poor responders undergoing in vitro fertilization: a randomized controlled trial. Fertil Steril. 101:147–153. 2014. View Article : Google Scholar

6 

IVF Worldwide Survey: Poor responders: how to define, diagnose and treat? Downloadable at: http://www.IVF-Worldwide.com. (Accessed: 24/02/2014).

7 

Shimada M, Hernandez-Gonzalez I, Gonzalez-Robayna I and Richards JS: Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells: key roles for prostaglandin synthase 2 and progesterone receptor. Mol Endocrinol. 20:1352–1365. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Alviggi C, Clarizia R, Mollo A, Ranieri A and De Placido G: Who needs LH in ovarian stimulation? Reprod Biomed Online. 22(Suppl 1): 33–41. 2011. View Article : Google Scholar

9 

Patrelli TS, Berretta R, Gizzo S, Pezzuto A, Franchi L, Lukanovic A, et al: CA 125 serum values in surgically treated endometriosis patients and its relationships with anatomic sites of endometriosis and pregnancy rate. Fertil Steril. 95:393–396. 2011. View Article : Google Scholar

10 

Saccardi C, Conte L, Fabris A, De Marchi F, Borghero A, Gizzo S, et al: Hysteroscopic Enucleation in Toto of Submucous type 2 myomas: Long-term follow-up in women affected by Menorrhagia. J Minim Invasive Gynecol. 21:426–430. 2014. View Article : Google Scholar

11 

Litta P, Cosmi E, Saccardi C, Esposito C, Rui R and Ambrosini G: Outpatient operative polypectomy using a 5 mm-hysteroscope without anaesthesia and/or analgesia: advantages and limits. Eur J Obstet Gynecol Reprod Biol. 139:210–214. 2008. View Article : Google Scholar : PubMed/NCBI

12 

World Health Organization: WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. Cambridge, UK: Cambridge University Press; 1999

13 

Gizzo S, Capuzzo D, Zicchina C, Di Gangi S, Coronella ML, Andrisani A, et al: Could empirical low-dose-aspirin administration during IVF cycle affect both the oocytes and embryos quality via COX 1 2 activity inhibition? J Assist Reprod Genet. 31:261–8. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Gizzo S, Patrelli TS, Rossanese M, Noventa M, Berretta R, Di Gangi S, et al: An update on diabetic women obstetrical outcomes linked to preconception and pregnancy glycemic profile: a systematic literature review. Scientific World Journal. 2013:2549012013. View Article : Google Scholar : PubMed/NCBI

15 

Saccardi C, Gizzo S, Ludwig K, Guido M, Scarton M, Gangemi M, et al: Endometrial polyps in women affected by levothyroxine-treated hypothyroidism-histological features, immunohistochemical findings and possible explanation of etiopathogenic mechanism: a pilot study. Biomed Res Int. 2013:5034192013. View Article : Google Scholar

16 

Gizzo S, Andrisani A, Esposito F, Noventa M, Di Gangi S, Angioni S, et al: Which luteal phase support is better for each IVF stimulation protocol to achieve the highest pregnancy rate? A superiority randomized clinical trial. Gynecol Endocrinol. 30:1–7. 2014. View Article : Google Scholar

17 

Son WY, Chung JT, Henderson S, Reinblatt S, Buckett W, Chan PT, et al: Fertilization and embryo development with spermatozoa obtained from testicular sperm extraction into oocytes generated from human chorionic gonadotropin-primed in vitro maturation cycles. Fertil Steril. 100:989–993. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Khoudja R, Li T, Ding C, Xu Y, Liu Y, Zhou W and Zhou C: Effect of co-incubation of oocytes with a decreasing number of spermatozoa on embryo quality. Reprod Biomed Online. 26:353–359. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Mochtar MH, Veen Van der, Ziech M and van Wely M: Recombinant luteinizing hormone (rLH) for controlled ovarian hyperstimulation in assisted reproductive cycles. Cochrane Database Syst Rev. 18:CD0050702007.

20 

De Placido G, Mollo A, Clarizia R, Strina I, Conforti S and Alviggi C: Gonadotropin-releasing hormone (GnRH) antagonist plus recombinant luteinizing hormone vs. a standard GnRH agonist short protocol in patients at risk for poor ovarian response. Fertil Steril. 85:247–250. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Bosch E, Labarta E, Crespo J, Simón C, Remohí J and Pellicer A: Impact of luteinizing hormone administration on gonadotropin-releasing hormone antagonist cycles: an age-adjusted analysis. Fertil Steril. 95:1031–1036. 2011. View Article : Google Scholar

22 

König TE, van der Houwen LE, Overbeek A, Hendriks ML, Beutler-Beemsterboer SN, Kuchenbecker WK, et al: Recombinant LH supplementation to a standard GnRH antagonist protocol in women of 35 years or older undergoing IVF/ICSI: a randomized controlled multicentre study. Hum Reprod. 28:2804–2812. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Filicori M, Cognigni GE, Pocognoli P, Ciampaglia W and Bernardi S: Current concepts and novel applications of LH activity in ovarian stimulation. Trends Endocrinol Metab. 14:267–273. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Willis DS, Watson H, Mason HD, Galea R, Brincat M and Franks S: Premature response to luteinizing hormone of granulosa cells from anovulatory women with polycystic ovary syndrome: relevance to mechanism of anovulation. J Clin Endocrinol Metab. 83:3984–3991. 1998.PubMed/NCBI

25 

Filicori M, Cognigni GE and Ciampaglia W: What clinical evidence for an LH ceiling? Hum Reprod. 18:1556–1557. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Gizzo S, Andrisani A, Noventa M, Quaranta M, Esposito F, Armanini D, et al: Menstrual cycle length: a surrogate measure of reproductive health capable of improving the accuracy of biochemical/sonographical ovarian reserve test in estimating the reproductive chances of women referred to ART. Reprod Biol Endocrinol. 13:282015. View Article : Google Scholar : PubMed/NCBI

27 

Ruvolo G, Bosco L, Pane A, Morici G, Cittadini E and Roccheri MC: Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vitro fertilization procedures. Fertil Steril. 87:542–546. 2007. View Article : Google Scholar

28 

Barberi M, Ermini B, Morelli MB, Ermini M, Cecconi S and Canipari R: Follicular fluid hormonal profile and cumulus cell gene expression in controlled ovarian hyperstimulation with recombinant FSH: effects of recombinant LH administration. J Assist Reprod Genet. 29:1381–1391. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Kolibianakis EM, Albano C, Camus M, Tournaye H, Van Steirteghem AC and Devroey P: Initiation of gonadotropin-releasing hormone antagonist on day 1 as compared to day 6 of stimulation: effect on hormonal levels and follicular development in in vitro fertilization cycles. J Clin Endocrinol Metab. 88:5632–5637. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Kolibianakis EM, Albano C, Kahn J, Camus M, Tournaye H, Van Steirteghem AC, et al: Exposure to high levels of luteinizing hormone and estradiol in the early follicular phase of gonadotropin-releasing hormone antagonist cycles is associated with a reduced chance of pregnancy. Fertil Steril. 79:873–880. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Kolibianakis E, Bourgain C, Albano C, Osmanagaoglu K, Smitz J, Van Steirteghem A, et al: Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin-releasing hormone antagonists and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril. 78:1025–1029. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gizzo S, Andrisani A, Noventa M, Manfè S, Oliva A, Gangemi M, Nardelli GB and Ambrosini G: Recombinant LH supplementation during IVF cycles with a GnRH-antagonist in estimated poor responders: A cross-matched pilot investigation of the optimal daily dose and timing. Mol Med Rep 12: 4219-4229, 2015.
APA
Gizzo, S., Andrisani, A., Noventa, M., Manfè, S., Oliva, A., Gangemi, M. ... Ambrosini, G. (2015). Recombinant LH supplementation during IVF cycles with a GnRH-antagonist in estimated poor responders: A cross-matched pilot investigation of the optimal daily dose and timing. Molecular Medicine Reports, 12, 4219-4229. https://doi.org/10.3892/mmr.2015.3904
MLA
Gizzo, S., Andrisani, A., Noventa, M., Manfè, S., Oliva, A., Gangemi, M., Nardelli, G. B., Ambrosini, G."Recombinant LH supplementation during IVF cycles with a GnRH-antagonist in estimated poor responders: A cross-matched pilot investigation of the optimal daily dose and timing". Molecular Medicine Reports 12.3 (2015): 4219-4229.
Chicago
Gizzo, S., Andrisani, A., Noventa, M., Manfè, S., Oliva, A., Gangemi, M., Nardelli, G. B., Ambrosini, G."Recombinant LH supplementation during IVF cycles with a GnRH-antagonist in estimated poor responders: A cross-matched pilot investigation of the optimal daily dose and timing". Molecular Medicine Reports 12, no. 3 (2015): 4219-4229. https://doi.org/10.3892/mmr.2015.3904
Copy and paste a formatted citation
x
Spandidos Publications style
Gizzo S, Andrisani A, Noventa M, Manfè S, Oliva A, Gangemi M, Nardelli GB and Ambrosini G: Recombinant LH supplementation during IVF cycles with a GnRH-antagonist in estimated poor responders: A cross-matched pilot investigation of the optimal daily dose and timing. Mol Med Rep 12: 4219-4229, 2015.
APA
Gizzo, S., Andrisani, A., Noventa, M., Manfè, S., Oliva, A., Gangemi, M. ... Ambrosini, G. (2015). Recombinant LH supplementation during IVF cycles with a GnRH-antagonist in estimated poor responders: A cross-matched pilot investigation of the optimal daily dose and timing. Molecular Medicine Reports, 12, 4219-4229. https://doi.org/10.3892/mmr.2015.3904
MLA
Gizzo, S., Andrisani, A., Noventa, M., Manfè, S., Oliva, A., Gangemi, M., Nardelli, G. B., Ambrosini, G."Recombinant LH supplementation during IVF cycles with a GnRH-antagonist in estimated poor responders: A cross-matched pilot investigation of the optimal daily dose and timing". Molecular Medicine Reports 12.3 (2015): 4219-4229.
Chicago
Gizzo, S., Andrisani, A., Noventa, M., Manfè, S., Oliva, A., Gangemi, M., Nardelli, G. B., Ambrosini, G."Recombinant LH supplementation during IVF cycles with a GnRH-antagonist in estimated poor responders: A cross-matched pilot investigation of the optimal daily dose and timing". Molecular Medicine Reports 12, no. 3 (2015): 4219-4229. https://doi.org/10.3892/mmr.2015.3904
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