Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2015 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma

  • Authors:
    • In‑Sik Shin
    • Na‑Rae Shin
    • Chan‑Mi Jeon
    • Ok‑Kyoung Kwon
    • Ju‑Mi Hong
    • Hui‑Seong Kim
    • Sei‑Ryang Oh
    • Kyung‑Seop Ahn
  • View Affiliations / Copyright

    Affiliations: Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon‑gun, Chungbuk 363‑883, Republic of Korea
  • Pages: 4640-4646
    |
    Published online on: June 11, 2015
       https://doi.org/10.3892/mmr.2015.3910
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Thuja orientalis (TO) may be used as a herbal remedy for the treatment of numerous inflammatory diseases. In the present study, the effects of TO were evaluated on airway inflammation in ovalbumin (OVA)‑induced allergic asthma and RAW264.7 murine macrophage cells. The effects of TO on the production of proinflammatory mediators, were determined in RAW264.7 cells that had been stimulated with lipopolysaccharide (LPS). Furthermore, an in vivo experiment was performed on mice that were sensitized to OVA and then received an OVA airway challenge. TO was administered by daily oral gavage at a dose of 30 mg/kg, 21‑23 days after the initial OVA sensitization. TO was shown to reduce nitric oxide production and reduce the relative mRNA expression levels of inducible nitric oxide synthase (iNOS), interleukin (IL)‑6, cyclooxygenase‑2, matrix metalloproteinase (MMP)‑9, and tumor necrosis factor‑α in RAW264.7 cells stimulated with LPS. In addition, TO markedly decreased the inflammatory cell counts in bronchial alveolar lavage fluid, reduced the levels of IL‑4, IL‑5, IL‑13, eotaxin and immunoglobulin E, and reduced airway hyperresponsivenes, in the OVA sensitized mice. Furthermore, TO attenuated airway inflammation and mucus hypersecretion, induced by the OVA challenge of the lung tissue. TO also reduced the expression of iNOS and MMP‑9 in lung tissue. In conclusion, TO exerted anti‑inflammatory effects in an OVA‑induced allergic asthma model, and in LPS‑stimulated RAW264.7 cells. These results suggest that TO may be a useful therapeutic agent for the treatment of inflammatory diseases, including allergic asthma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Lee MY, Seo CS, Lee JA, et al: Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1. Food Chem Toxicol. 49:829–837. 2011. View Article : Google Scholar

2 

Gueders MM, Bertholet P, Perin F, et al: A novel formulation of inhaled doxycycline reduces allergen-induced inflammation, hyperresponsiveness and remodeling by matrix metalloproteinases and cytokines modulation in a mouse model of asthma. Biochem Pharmacol. 75:514–526. 2008. View Article : Google Scholar

3 

Holgate ST: The airway epithelium is central to the pathogenesis of asthma. Allergol Int. 57:1–10. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Zhou DY, Du Q, Li RR, Huang M, Zhang Q and Wei GZ: Grape seed proanthocyanidin extract attenuates airway inflammation and hyper-responsiveness in a murine model of asthma by downregulating inducible nitric oxide synthase. Planta Med. 77:1575–1581. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Ricciardolo FL, Sterk PJ, Gaston B and Folkerts G: Nitric oxide in health and disease of the respiratory system. Physiol Rev. 84:731–765. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Islam T, Breton C, Salam MT, et al: Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. Thorax. 65:139–145. 2010. View Article : Google Scholar

7 

Prado CM, Leick-Maldonado EA, Yano L, et al: Effects of nitric oxide synthases in chronic allergic airway inflammation and remodeling. Am J Respir Cell Mol Biol. 35:457–465. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Jung SH, Kim BJ, Lee EH and Osborne NN: Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int. 57:713–721. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Lee YJ, Hwang SM, Yoon JJ, et al: Inhibitory effect of Thuja orientalis on TNF-α-induced vascular inflammation. Phytother Res. 24:1489–1495. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Chae HS and Chin YW: Anti-allergic effects of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells. Immunopharmacol Immunotoxicol. 34:250–255. 2012. View Article : Google Scholar

11 

Won JN, Lee SY, Song DS and Poo H: Antiviral activity of the plant extracts from Thuja orientalis, Aster spathulifolius, and Pinus thunbergii against influenza virus A/PR/8/34. J Microbiol Biotechnol. 23:125–130. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Xu GH, Ryoo IJ, Kim YH, Choo SJ and Yoo ID: Free radical scavenging and antielastase activities of flavonoids from the fruits of Thuja orientalis. Arch Pharm Res. 32:275–282. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Jung HW, Kang SY, Park KH, et al: Effect of the semen extract of Thuja orientalis on inflammatory responses in transient focal cerebral ischemia rat model and LPS-stimulated BV-2 microglia. Am J Chin Med. 41:99–117. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Kim TH, Li H, Wu Q, Lee HJ and Ryu JH: A new labdane diter-penoide with anti-inflammatory activity from Thuja orientalis. J Ethnopharmacol. 146:760–767. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Heussen C and Dowdel EB: Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrate. Anal Biochem. 102:196–202. 1980. View Article : Google Scholar : PubMed/NCBI

16 

Uhm TG, Kim BS and Chung IY: Eosinophil development, regulation of eosinophil-specific genes, and role of eosinophils in the pathogenesis of asthma. Allergy Asthma Immunol Res. 4:68–79. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Pope SM, Brandt EB, Mishra A, et al: IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism. J Allergy Clin Immunol. 108:594–601. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Pope SM, Zimmermann N, Stringer KF, Karow ML and Rothenberg ME: The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia. J Immuno. 175:5341–5350. 2005. View Article : Google Scholar

19 

Mould AW, Ramsay AJ, Matthaei KI, Young IG, Rothernberg ME and Foster PS: The effects of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity. J Immunol. 164:2142–2150. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Pease JE and Williams TJ: Chemokines and their receptors in allergic disease. J Allergy Clin Immunol. 118:305–318. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Hesslinger C, Strub A, Boer R, Ulrich WR, Lehner MD and Braun C: Inhibition of inducible nitric oxide synthase in respiratory diseases. Biochem Soc Trans. 37:886–891. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Starling CM, Prado CM, Leick-Maldonado EA, et al: Inducible nitric oxide synthase inhibition attenuates lung tissue responsiveness and remodeling in a model of chronic pulmonary inflammation in guinea pigs. Respir Physiol Neurobiol. 165:185–194. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Prado CM, Yano L, Rocha G, et al: Effects of inducible nitric oxide synthase inhibition in bronchial vascular remodeling-induced by chronic allergic pulmonary inflammation. Exp Lung Res. 37:259–268. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Vermaelen KY, Cataldo D, Tournoy K, et al: Matrix metallopro-teinase-9-mediated dendritic cell recruitment into the airways is a critical step in a mouse model of asthma. J Immunol. 171:1016–1022. 2003. View Article : Google Scholar : PubMed/NCBI

25 

McMillan SJ, Kearley J, Campbell JD, et al: Matrix metallopro-teinase-9 deficiency results in enhanced allergen-induced airway inflammation. J Immunol. 172:2586–2594. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shin IS, Shin NR, Jeon CM, Kwon OK, Hong JM, Kim HS, Oh SR and Ahn KS: Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma. Mol Med Rep 12: 4640-4646, 2015.
APA
Shin, I., Shin, N., Jeon, C., Kwon, O., Hong, J., Kim, H. ... Ahn, K. (2015). Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma. Molecular Medicine Reports, 12, 4640-4646. https://doi.org/10.3892/mmr.2015.3910
MLA
Shin, I., Shin, N., Jeon, C., Kwon, O., Hong, J., Kim, H., Oh, S., Ahn, K."Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma". Molecular Medicine Reports 12.3 (2015): 4640-4646.
Chicago
Shin, I., Shin, N., Jeon, C., Kwon, O., Hong, J., Kim, H., Oh, S., Ahn, K."Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma". Molecular Medicine Reports 12, no. 3 (2015): 4640-4646. https://doi.org/10.3892/mmr.2015.3910
Copy and paste a formatted citation
x
Spandidos Publications style
Shin IS, Shin NR, Jeon CM, Kwon OK, Hong JM, Kim HS, Oh SR and Ahn KS: Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma. Mol Med Rep 12: 4640-4646, 2015.
APA
Shin, I., Shin, N., Jeon, C., Kwon, O., Hong, J., Kim, H. ... Ahn, K. (2015). Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma. Molecular Medicine Reports, 12, 4640-4646. https://doi.org/10.3892/mmr.2015.3910
MLA
Shin, I., Shin, N., Jeon, C., Kwon, O., Hong, J., Kim, H., Oh, S., Ahn, K."Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma". Molecular Medicine Reports 12.3 (2015): 4640-4646.
Chicago
Shin, I., Shin, N., Jeon, C., Kwon, O., Hong, J., Kim, H., Oh, S., Ahn, K."Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma". Molecular Medicine Reports 12, no. 3 (2015): 4640-4646. https://doi.org/10.3892/mmr.2015.3910
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team