Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2015 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Genomic expression profiling and bioinformatics analysis of pancreatic cancer

  • Authors:
    • Dong‑Yan Han
    • Da Fu
    • Hao Xi
    • Qian‑Yu Li
    • Li‑Jin Feng
    • Wei Zhang
    • Guo Ji
    • Jia‑Cheng Xiao
    • Qing Wei
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Shanghai Tenth People's Hospital, Shanghai 200072, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 4133-4140
    |
    Published online on: June 11, 2015
       https://doi.org/10.3892/mmr.2015.3917
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pancreatic cancer is a polygenic disease and the fourth leading cause of cancer-associated mortality worldwide; however, the tumorigenesis of pancreatic cancer remains poorly understood. Research at a molecular level, which includes the exploration of biomarkers for early diagnosis and specific targets for therapy, may effectively aid in the diagnosis of pancreatic cancer in its early stages and in the development of targeted molecular‑biological approaches for treatment, thus improving prognosis. By conducting expression profiling in para‑carcinoma, carcinoma and relapse of human pancreatic tissues, 319 genes or transcripts with differential expression levels >3‑fold between these tissue types were identified. Further analysis with Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes demonstrated that the translation, nucleus assembly processes and molecular functions associated with vitamin B6 and pyridoxal phosphate binding in pancreatic carcinoma were abnormal. Pancreatic cancer was additionally identified to be closely associated with certain autoimmune diseases, including type I diabetes mellitus and systemic lupus erythematosus.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ghaneh P, Smith R, Tudor-Smith C, Raraty M and Neoptolemos JP: Neoadjuvant and adjuvant strategies for pancreatic cancer. Eur J Surg Oncol. 34:297–305. 2008. View Article : Google Scholar

2 

Sugimura T, Terada M, Yokota J, Hirohashi S and Wakabayashi K: Multiple genetic alterations in human carcinogenesis. Environ Health Perspect. 98:5–12. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Neoptolemos JP, Urrutia R, Abbruzzese JL and Büchler MW: Pancreatic Cancer. Chapter. 21:498–505. 2010.

4 

Rafael S, Veganzones S, Vidaurreta M, de la Orden V and Maestro ML: Effect of β-catenin alterations in the prognosis of patients with sporadic colorectal cancer. J Cancer Res Ther. 10:591–596. 2014.PubMed/NCBI

5 

López-Casas PP and López-Fernández LA: Gene-expression profiling in pancreatic cancer. Expert Rev Mol Diagn. 10:591–601. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Maitra A, Kern SE and Hruban RH: Molecular pathogenesis of pancreatic cancer. Best Pract Res Clin Gastroenterol. 20:211–226. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Li Q and Xu W: Novel anticancer targets and drug discovery in post genomic age. Curr Med Chem Anticancer Agents. 5:53–63. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Downward J: Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 3:11–22. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Morris JP IV, Wang SC and Hebrok M: KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer. 10:683–695. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Wang Z, Banerjee S, Ahmad A, Li Y, Azmi AS, Gunn JR, Kong D, Bao B, Ali S, Gao J, et al: Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-κB signaling pathways. PLoS One. 6:e205372011. View Article : Google Scholar

11 

Lauth M and Toftgård R: Hedgehog signaling and pancreatic tumor development. Adv Cancer Res. 110:1–17. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Huang da W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar :

13 

Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, Miller DK, Wilson PJ, Patch AM, Wu J, et al: Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature. 491:399–405. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Hidalgo M: Pancreatic cancer. N Engl J Med. 362:1605–1617. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Shain AH, Salari K, Giacomini CP and Pollack JR: Integrative genomic and functional profiling of the pancreatic cancer genome. BMC Genomics. 14:6242013. View Article : Google Scholar : PubMed/NCBI

16 

Mohr S, Leikauf GD, Keith G and Rihn BH: Microarrays as cancer keys: An array of possibilities. J Clin Oncol. 20:3165–3175. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Chang ZY, Sun R, Ma YS, Fu D, Lai XL, Li YS, Wang XH, Zhang XP, Lv ZW, Cong XL, et al: Differential gene expression of the key signalling pathway in para-carcinoma, carcinoma and relapse human pancreatic cancer. Cell Biochem Funct. 32:258–267. 2014. View Article : Google Scholar

18 

Nakamura T, Furukawa Y, Nakagawa H, Tsunoda T, Ohigashi H, Murata K, Ishikawa O, Ohgaki K, Kashimura N, Miyamoto M, et al: Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection. Oncogene. 23:2385–2400. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Backman V, Wallace MB, Perelman LT, Arendt JT, Gurjar R, Müller MG, Zhang Q, Zonios G, Kline E, McGilligan JA, et al: Detection of preinvasive cancer cells. Nature. 406:35–36. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Schernhammer E, Wolpin B, Rifai N, Cochrane B, Manson JA, Ma J, Giovannucci E, Thomson C, Stampfer MJ and Fuchs C: Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. Cancer Res. 67:5553–5560. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Johansson M, Relton C, Ueland PM, Vollset SE, Midttun Ø, Nygård O, Slimani N, Boffetta P, Jenab M, Clavel-Chapelon F, et al: Serum B vitamin levels and risk of lung cancer. JAMA. 303:2377–2385. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Wu W, Kang S and Zhang D: Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: A dose-response meta-analysis. Br J Cancer. 109:1926–1944. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Dubois EL: The effect of the L. E. cell test on the clinical picture of systemic lupus erythematosus. Ann Intern Med. 38:1265–1294. 1953. View Article : Google Scholar : PubMed/NCBI

24 

Smedby KE, Hjalgrim H, Askling J, Chang ET, Gregersen H, Porwit-MacDonald A, Sundström C, Akerman M, Melbye M, Glimelius B, et al: Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype. J Natl Cancer Inst. 98:51–60. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Björnådal L, Löfström B, Yin L, Lundberg IE and Ekbom A: Increased cancer incidence in a Swedish cohort of patients with systemic lupus erythematosus. Scand J Rheumatol. 31:66–71. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Cibere J, Sibley J and Haga M: Systemic lupus erythematosus and the risk of malignancy. Lupus. 10:394–400. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Pettersson T, Pukkala E, Teppo L and Friman C: Increased risk of cancer in patients with systemic lupus erythematosus. Ann Rheum Dis. 51:437–439. 1992. View Article : Google Scholar : PubMed/NCBI

28 

Bernatsky S, Ramsey-Goldman R, Rajan R, Boivin JF, Joseph L, Lachance S, Cournoyer D, Zoma A, Manzi S, Ginzler E, et al: Non-Hodgkin's lymphoma in systemic lupus erythematosus. Ann Rheum Dis. 64:1507–1509. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Ramsey-Goldman R, Mattai SA, Schilling E, Chiu YL, Alo CJ, Howe HL and Manzi S: Increased risk of malignancy in patients with systemic lupus erythematosus. J Investig Med. 46:217–222. 1998.PubMed/NCBI

30 

Bernatsky S, Ramsey-Goldman R, Isenberg D, Isenberg D, Rahman A, Dooley MA, Sibley J, Boivin JF, Joseph L, Armitage J, et al: Hodgkin's lymphoma in systemic lupus erythematosus. Rheumatology (Oxford). 46:830–832. 2007. View Article : Google Scholar

31 

Landgren O, Engels EA, Pfeiffer RM, Gridley G, Mellemkjaer L, Olsen JH, Kerstann KF, Wheeler W, Hemminki K, Linet MS, et al: Autoimmunity and susceptibility to Hodgkin lymphoma: A population-based case-control study in Scandinavia. J Natl Cancer Inst. 98:1321–1330. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Gayed M, Bernatsky S, Ramsey-Goldman R, Clarke A and Gordon C: Lupus and cancer. Lupus. 18:479–485. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Bernatsky S, Boivin JF, Joseph L, Manzi S, Ginzler E, Gladman DD, Urowitz M, Fortin PR, Petri M, Barr S, et al: Mortality in systemic lupus erythematosus. Arthritis Rheum. 54:2550–2557. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Thomas E, Brewster DH, Black RJ and Macfarlane GJ: Risk of malignancy among patients with rheumatic conditions. Int J Cancer. 88:497–502. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Mellemkjér L, Andersen V, Linet MS, et al: Non-Hodgkin's lymphoma and other cancers among a cohort of patients with systemic lupus erythematosus. Arthritis Rheum. 40:761–768. 1997. View Article : Google Scholar

36 

Bernatsky S, Ramsey-Goldman R and Clarke AE: Revisiting the issue of malignancy risk in systemic lupus erythematosus. Curr Rheumatol Rep. 7:476–481. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Ruiz-Irastorza G, Ugarte A, Egurbide MV, Garmendia M, Pijoan JI, Martinez-Berriotxoa A and Aguirre C: Antimalarials may influence the risk of malignancy in systemic lupus erythematosus. Ann Rheum Dis. 66:815–817. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Bernatsky S, Boivin JF, Joseph L, Rajan R, Zoma A, Manzi S, Ginzler E, Urowitz M, Gladman D, Fortin PR, et al: An international cohort study of cancer in systemic lupus erythematosus. Arthritis Rheum. 52:1481–1490. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Akerblom HK and Knip M: Putative environmental factors in Type 1 diabetes. Diabetes Metab Rev. 14:31–67. 1998. View Article : Google Scholar : PubMed/NCBI

40 

Stevens RJ, Roddam AW and Beral V: Pancreatic cancer in type 1 and young-onset diabetes: Systematic review and meta-analysis. Br J Cancer. 96:507–509. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Zendehdel K, Nyrén O, Ostenson CG, Adami HO, Ekbom A and Ye W: Cancer incidence in patients with type 1 diabetes mellitus: A population-based cohort study in Sweden. J Natl Cancer Inst. 95:1797–1800. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Han DY, Fu D, Xi H, Li QY, Feng LJ, Zhang W, Ji G, Xiao JC and Wei Q: Genomic expression profiling and bioinformatics analysis of pancreatic cancer. Mol Med Rep 12: 4133-4140, 2015.
APA
Han, D., Fu, D., Xi, H., Li, Q., Feng, L., Zhang, W. ... Wei, Q. (2015). Genomic expression profiling and bioinformatics analysis of pancreatic cancer. Molecular Medicine Reports, 12, 4133-4140. https://doi.org/10.3892/mmr.2015.3917
MLA
Han, D., Fu, D., Xi, H., Li, Q., Feng, L., Zhang, W., Ji, G., Xiao, J., Wei, Q."Genomic expression profiling and bioinformatics analysis of pancreatic cancer". Molecular Medicine Reports 12.3 (2015): 4133-4140.
Chicago
Han, D., Fu, D., Xi, H., Li, Q., Feng, L., Zhang, W., Ji, G., Xiao, J., Wei, Q."Genomic expression profiling and bioinformatics analysis of pancreatic cancer". Molecular Medicine Reports 12, no. 3 (2015): 4133-4140. https://doi.org/10.3892/mmr.2015.3917
Copy and paste a formatted citation
x
Spandidos Publications style
Han DY, Fu D, Xi H, Li QY, Feng LJ, Zhang W, Ji G, Xiao JC and Wei Q: Genomic expression profiling and bioinformatics analysis of pancreatic cancer. Mol Med Rep 12: 4133-4140, 2015.
APA
Han, D., Fu, D., Xi, H., Li, Q., Feng, L., Zhang, W. ... Wei, Q. (2015). Genomic expression profiling and bioinformatics analysis of pancreatic cancer. Molecular Medicine Reports, 12, 4133-4140. https://doi.org/10.3892/mmr.2015.3917
MLA
Han, D., Fu, D., Xi, H., Li, Q., Feng, L., Zhang, W., Ji, G., Xiao, J., Wei, Q."Genomic expression profiling and bioinformatics analysis of pancreatic cancer". Molecular Medicine Reports 12.3 (2015): 4133-4140.
Chicago
Han, D., Fu, D., Xi, H., Li, Q., Feng, L., Zhang, W., Ji, G., Xiao, J., Wei, Q."Genomic expression profiling and bioinformatics analysis of pancreatic cancer". Molecular Medicine Reports 12, no. 3 (2015): 4133-4140. https://doi.org/10.3892/mmr.2015.3917
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team