High-density lipoprotein synthesis and metabolism (Review)

  • Authors:
    • Lingyan Zhou
    • Congcong Li
    • Ling Gao
    • Aihong Wang
  • View Affiliations

  • Published online on: June 15, 2015     https://doi.org/10.3892/mmr.2015.3930
  • Pages: 4015-4021
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Abstract

High density lipoproteins (HDL) are heterogeneous particles regarding their size and composition. They have vital functions in reverse cholesterol transport (RCT). RCT occurs when lipid-free apolipoprotein AI recruits cholesterol and phospholipid to form nascent HDL particles. Adenosine triphosphate‑binding cassette transporters and scavenger receptor class B type I were found to be associated with the synthesis of HDL. Experimental studies have identified several potential anti‑atherogenic effects of HDL, including promotion of macrophage cholesterol outflow as well as anti‑inflammatory and anti‑thrombotic effects. HDL can also transport microRNAs. This review mainly summarizes the present knowledge of HDL synthesis and metabolism.
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September-2015
Volume 12 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhou L, Li C, Gao L and Wang A: High-density lipoprotein synthesis and metabolism (Review). Mol Med Rep 12: 4015-4021, 2015
APA
Zhou, L., Li, C., Gao, L., & Wang, A. (2015). High-density lipoprotein synthesis and metabolism (Review). Molecular Medicine Reports, 12, 4015-4021. https://doi.org/10.3892/mmr.2015.3930
MLA
Zhou, L., Li, C., Gao, L., Wang, A."High-density lipoprotein synthesis and metabolism (Review)". Molecular Medicine Reports 12.3 (2015): 4015-4021.
Chicago
Zhou, L., Li, C., Gao, L., Wang, A."High-density lipoprotein synthesis and metabolism (Review)". Molecular Medicine Reports 12, no. 3 (2015): 4015-4021. https://doi.org/10.3892/mmr.2015.3930