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Review

Diagnostic and therapeutic research on ultrasound microbubble/nanobubble contrast agents (Review)

  • Authors:
    • Jing Ma
    • Chang Song Xu
    • Feng Gao
    • Ming Chen
    • Fan Li
    • Lian Fang Du
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China, Department of Ultrasound, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China, Department of Cardiovascular Ultrasound, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, P.R. China
  • Pages: 4022-4028
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    Published online on: June 16, 2015
       https://doi.org/10.3892/mmr.2015.3941
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Abstract

The contrast enhanced imaging function of ultrasound contrast agents (UCAs) has been extensively investigated using physical acoustic signatures. It has a number of novel applications, including tissue‑specific molecular imaging and multi‑modal imaging. In addition there are numerous other therapeutic applications of UCAs, for example as vehicles for drug or gene delivery. These uses are discussed, as well as the acoustically‑induced biological effects, including ultrasound targeted microbubble destruction (UTMD). This review also explores the considerations for the safe use of UCA from an acoustic standpoint. The scope of the application of UCA has markedly expanded in recent years, and it is a rapidly growing field of medical research. The current article reviews recent advances in the diagnostic and therapeutic applications of ultrasound microbubble/nanobubble contrast agents.
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1 

Xing ZW, Wang J, Ke H, et al: The fabrication of novel nano-bubble ultrasound contrast agent for potential tumor imaging. Nanotechnology. 21:1456072010. View Article : Google Scholar

2 

Tran TD, Caruthers SD, Hughes M, et al: Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics. Int J Nanomedicine. 2:515–526. 2007.

3 

Quaia E: Microbubble ultrasound contrast agents: an update. Eur Radiol. 17:1995–2008. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Sun C, Sboros V, Butler MB and Moran CM: In vitro acoustic characterization of three phospholipid ultrasound contrast agents from 12 to 43 MHz. Ultrasound Med Biol. 40:541–550. 2014. View Article : Google Scholar :

5 

Pfister K, Kasprzak PM, Apfelbeck H, et al: The significance of contrast-enhanced ultrasound in vascular surgery. Zentralbl Chi. Dec 10–2013.(Epub ahead of print) (In German).

6 

Liu H, Jiang Y, Dai Q, et al: Peripheral enhancement of breast cancers on contrast-enhanced ultrasound: correlation with microvessel density and vascular endothelial growth factor expression. Ultrasound Med Biol. 40:293–299. 2014. View Article : Google Scholar

7 

Malinova M: Preoperative sonovue contrast color Doppler in patients with cervical cancer. Preliminary report. Akush Ginekol (Sofiia). 52(Suppl 1): 11–16. 2013.In Bulgarian.

8 

Hoffmann R, von Bardeleben S, Barletta G, et al: Comparison of two- and three-dimensional unenhanced and contrast-enhanced echocardiographies versus cineventriculography versus cardiac magnetic resonance for determination of left ventricular function. Am J Cardiol. 113:395–401. 2014. View Article : Google Scholar

9 

Sartori S, Postorivo S, Vece FD, et al: Contrast-enhanced ultrasonography in peripheral lung consolidations: What's its actual role? World J Radiol. 5:372–380. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Saracco A, Szabó BK, Aspelin P, et al: Contrast-enhanced ultrasound using real-time contrast harmonic imaging in invasive breast cancer: comparison of enhancement dynamics with three different doses of contrast agent. Acta Radiol. Jan 20–2014.Epub ahead of print. PubMed/NCBI

11 

Lisowska A, Knapp M, Tycinska A, et al: Usefulness of automatic measurement of contrast flow intensity: an innovative tool in contrast-enhanced ultrasound imaging of atherosclerotic carotid plaque neovascularization. A pilot study. Int Angiol. 33:50–57. 2014.PubMed/NCBI

12 

Nagesha D, Laevsky GS, Lampton P, et al: In vitro imaging of embryonic stem cells using multiphoton luminescence of gold nanoparticles. Int J Nanomedicine. 2:813–819. 2007.

13 

Threlfall G, Wu HJ, Li K, et al: Quantitative guidelines for the prediction of ultrasound contrast agent destruction during injection. Ultrasound Med Biol. 39:1838–1847. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Chen ZY, Liang K, Lin Y and Yang F: Study of the UTMD-based delivery system to induce cervical cancer cell apoptosis and inhibit proliferation with shRNA targeting Survivin. Int J Mol Sci. 14:1763–1777. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Li F, Jin L, Wang H, et al: The dual effect of ultrasound-targeted microbubble destruction in mediating recombinant adeno-associated virus delivery in renal cell carcinoma: transfection enhancement and tumor inhibition. J Gene Med. 16:28–39. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Liu H, Chang S, Sun J, et al: Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles induces proliferation inhibition and apoptosis in ovarian cancer cells. Mol Pharm. 11:40–48. 2014. View Article : Google Scholar :

17 

Pu C, Chang S, Sun J, et al: Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles for the treatment of intraperitoneal ovarian cancer xenografts. Mol Pharm. 11:49–58. 2014. View Article : Google Scholar :

18 

Yan P, Chen KJ, Wu J, et al: The use of MMP2 antibody-conjugated cationic microbubble to target the ischemic myocardium, enhance Timp3 gene transfection and improve cardiac function. Biomaterials. 35:1063–1073. 2014. View Article : Google Scholar

19 

Deng Q, Chen JL, Zhou Q, et al: Ultrasound microbubbles combined with the NFκB binding motif increase transfection efficiency by enhancing the cytoplasmic and nuclear import of plasmid DNA. Mol Med Rep. 8:1439–1445. 2013.PubMed/NCBI

20 

Ling ZY, Shu SY, Zhong SG, et al: Ultrasound targeted micro-bubble destruction promotes angiogenesis and heart function by inducing myocardial microenvironment change. Ultrasound Med Biol. 39:2001–2010. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Hao YN, Luo WL, Wang D and Wang ZG: Experimental research on treatment of injured facial nerves induced by hepatocyte growth factor mediated by ultrasound-targeted microbubble destruction. J Craniofac Surg. 24:421–424. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Yang D, Gao YH, Tan KB, et al: Inhibition of hepatic fibrosis with artificial microRNA using ultrasound and cationic liposome-bearing microbubbles. Gene Ther. 20:1140–1148. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Prentice P, Cushierp A, Dholakiak, et al: Membrane disruption by optically controlled microbubble cavitiation. Nat Phys. 1:107–110. 2005. View Article : Google Scholar

24 

Tachibana K, Uchida T, Ogawa K, et al: Induction of cell-membrane porosity by ultrasound. Lancet. 353:14091999. View Article : Google Scholar : PubMed/NCBI

25 

van Wamel A, Kooiman K, Harteveld M, et al: Vibrating micro-bubbles poking individual cells: drug transfer into cells via sonoporation. J Control Release. 112:149–155. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Juffermans LJ, Dijkmans PA, Musters RJ, et al: Transient permeabilization of cell membranes by ultrasound-exposed microbubbles is related to formation of hydrogen peroxide. Am J Physiol Heart Circ Physiol. 291:H1595–H1601. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Miller DL and Gies RA: The interaction of ultrasonic heating and cavitation in vascular bioeffects on mouse intestine. Ultrasound Med Biol. 24:123–128. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Schlicher RK, Radhakrishna H, Tolentino TP, et al: Mechanism of intracellular delivery by acoustic cavitation. Ultrasound Med Biol. 32:915–924. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Jin LF, Li F, Wang HP, et al: Ultrasound targeted microbubble destruction stimulates cellular endocytosis in facilitating adeno-associated virus delivery. Int J Mol Sci. 14:9737–9750. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Du J, Shi QS, Sun Y, et al: Enhanced delivery of monomethoxypoly(ethylene glycol)-poly(lactic-co-glycolic acid)-poly l-lysine nanoparticles loading platelet-derived growth factor BB small interfering RNA by ultrasound and/or micro-bubbles to rat retinal pigment epithelium cells. J Gene Med. 13:312–323. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Du J, Sun Y, Shi QS, et al: Biodegradable nanoparticles of mPEG-PLGA-PLL triblock copolymers as novel non-viral vectors for improving siRNA delivery and gene silencing. Int J Mol Sci. 13:516–533. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Shi Q, Liu P, Sun Y, et al: siRNA delivery mediated by copolymer nanoparticles, phospholipid stabilized sulphur hexa-fluoride microbubbles and ultrasound. J Biomed Nanotechnol. 10:436–444. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Jin L, Li F, Wang H, et al: Ultrasound-targeted microbubble destruction enhances gene transduction of adeno-associated virus in a less-permissive cell type, NIH/3T3. Mol Med Rep. 8:320–326. 2013.PubMed/NCBI

34 

Li HL, Zheng XZ, Wang HP, et al: Ultrasound-targeted micro-bubble destruction enhances AAV-mediated gene transfection in human RPE cells in vitro and rat retina in vivo. Gene Ther. 16:1146–1153. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Zheng X, Du L, Wang H and Gu Q: A novel approach to attenuate proliferative vitreoretinopathy using ultrasound-targeted microbubble destruction and recombinant adenoassociated virus-mediated RNA interference targeting transforming growth factor-b2 and platelet-derived growth factor-B. J Gene Med. 14:339–347. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Li YH, Jin LF, Du LF, et al: Enhancing HSP70-ShRNA transfection in 22RV1 prostate cancer cells by combination of sonoporation, liposomes and HTERT/CMV chimeric promoter. Int J Oncol. 43:151–158. 2013.PubMed/NCBI

37 

Zhang Y, Ye C, Wang G, et al: Kidney-targeted transplantation of mesenchymal stem cells by ultrasound targeted microbubble destruction promotes kidney repair in diabetic nephropathy rats. BioMed Res Int. 2013:5263672013. View Article : Google Scholar

38 

Li P, Gao Y, Zhang J, et al: Renal interstitial permeability changes induced by microbubble enhanced diagnostic ultrasound. J Drug Target. 21:507–514. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Jafari S, Diou O, Mamou J, Renault G, et al: High-frequency (20 to 40 MHz) acoustic response of liquid-filled nanocapsules. IEEE Trans Ultrason Ferroelectr Freq Control. 61:5–15. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Hughes GA: Nanostructure-mediated drug delivery. Nanomedicine. 1:22–30. 2005. View Article : Google Scholar

41 

Lanza GM, Trousil RL, Wallace KD, et al: In vitro characterization of a novel, tissue-targeted ultrasonic contrast system with acoustic microscopy. J Acoust Soc Am. 104:3665–3672. 1998. View Article : Google Scholar : PubMed/NCBI

42 

Sciallero C, Paradossi G and Trucco A: A preliminary in vitro assessment of polymer-shelled microbubbles in contrast-enhanced ultrasound imaging. Ultrasonics. 52:456–464. 2012. View Article : Google Scholar

43 

Nie L, Chen M, Sun X, et al: Palladium nanosheets as highly stable and effective contrast agents for in vivo photoacoustic molecular imaging. Nanoscale. 6:1271–1276. 2014. View Article : Google Scholar

44 

Trung, Tran TD, Caruthers SD, Hughes M, et al: Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics. Int J Nanomedicine. 2:515–526. 2007.

45 

Milgroom A, Intrator M, Madhavan K, et al: Mesoporous silica nanoparticles as a breast-cancer targeting ultrasound contrast agent. Colloids Surf B Biointerfaces. 11:652–657. 2014. View Article : Google Scholar

46 

Lin CA, Chuang WK, Huang ZY, et al: Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents. ACS Nano. 6:5111–5121. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Wilson KE, Wang TY and Willmann JK: Acoustic and photo-acoustic molecular imaging of cancer. J Nucl Med. 54:1851–1854. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Homan KA, Souza M, Truby R, et al: Silver nanoplate contrast agents for in vivo molecular photoacoustic imaging. ACS Nano. 6:641–650. 2012. View Article : Google Scholar

49 

Ku G, Zhou M, Song S, et al: Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm. ACS Nano. 6:7489–7496. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Sciallero C and Trucco A: Ultrasound assessment of polymer-shelled magnetic microbubbles used as dual contrast agents. J Acoust Soc Am. 133:EL478–EL484. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Kim C, Qin R, Xu JS, Wang LV and Xu R: Microbubbles and nanobubbles for photoacoustic and ultrasound imaging. J Biomed Opt. 15:0105102010. View Article : Google Scholar

52 

Xu JS, Huang J, Qin R, et al: Synthesizing and binding dual-mode poly (lactic-co-glycolicacid) (PLGA) nanobubbles for cancer targeting and imaging. Biomaterials. 31:1716–1722. 2010. View Article : Google Scholar

53 

Mehrmohammadi M, Shin TH, Qu M, et al: In vivo pulsed magneto-motive ultrasound imaging using high-performance magnetoactive contrast nanoagents. Nanoscale. 5:11179–11186. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Nie L, Chen M, Sun X, et al: Palladium nanosheets as highly stable and effective contrast agents for in vivo photoacoustic molecular imaging. Nanoscale. 6:1271–1276. 2014. View Article : Google Scholar

55 

Park J, Park D, Shin U, et al: Synthesis of laboratory ultrasound contrast agents. Molecules. 18:13078–13095. 2013. View Article : Google Scholar : PubMed/NCBI

56 

Barnett BP, Ruiz-Cabello J, Hota P, et al: Use of perfluorocarbon nanoparticles for non-invasive multimodal cell tracking of human pancreatic islets. Contrast Media Mol Imaging. 6:251–259. 2011.PubMed/NCBI

57 

Anayama T, Nakajima T, Dunne M, et al: A novel minimally invasive technique to create a rabbit VX2 lung tumor model for nano-sized image contrast and interventional studies. PLoS One. 8:e673552013. View Article : Google Scholar : PubMed/NCBI

58 

Arifin DR, Kedziorek DA, Fu Y, et al: Microencapsulated cell tracking. NMR Biomed. 26:850–859. 2013. View Article : Google Scholar :

59 

Cheng X, Li H, Chen Y, et al: Ultrasound-triggered phase transition sensitive magnetic fluorescent nanodroplets as a multimodal imaging contrast agent in rat and mouse model. PLoS One. 8:e850032013. View Article : Google Scholar

60 

Rapoport N, Gao Z and Kennedy A: Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J Natl Cancer Inst. 99:1095–1106. 2007. View Article : Google Scholar : PubMed/NCBI

61 

Ke H, Wang J, Dai Z, Jin Y, Qu E, Xing Z, Guo C, Yue X and Liu J: Gold-nanoshelled microcapsules: A theranostic agent for ultrasound contrast imaging and photothermal therapy. Angew Chem Int Ed Engl. 50:3017–3021. 2011. View Article : Google Scholar : PubMed/NCBI

62 

Ke H, Wang J, Tong S, et al: Gold nanoshelled liquid perfluoro-carbon magnetic nanocapsules: a nanotheranostic platform for bimodal ultrasound/magnetic resonance imaging guided photo-thermal tumor ablation. Theranostics. 4:12–23. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ma J, Xu CS, Gao F, Chen M, Li F and Du LF: Diagnostic and therapeutic research on ultrasound microbubble/nanobubble contrast agents (Review). Mol Med Rep 12: 4022-4028, 2015.
APA
Ma, J., Xu, C.S., Gao, F., Chen, M., Li, F., & Du, L.F. (2015). Diagnostic and therapeutic research on ultrasound microbubble/nanobubble contrast agents (Review). Molecular Medicine Reports, 12, 4022-4028. https://doi.org/10.3892/mmr.2015.3941
MLA
Ma, J., Xu, C. S., Gao, F., Chen, M., Li, F., Du, L. F."Diagnostic and therapeutic research on ultrasound microbubble/nanobubble contrast agents (Review)". Molecular Medicine Reports 12.3 (2015): 4022-4028.
Chicago
Ma, J., Xu, C. S., Gao, F., Chen, M., Li, F., Du, L. F."Diagnostic and therapeutic research on ultrasound microbubble/nanobubble contrast agents (Review)". Molecular Medicine Reports 12, no. 3 (2015): 4022-4028. https://doi.org/10.3892/mmr.2015.3941
Copy and paste a formatted citation
x
Spandidos Publications style
Ma J, Xu CS, Gao F, Chen M, Li F and Du LF: Diagnostic and therapeutic research on ultrasound microbubble/nanobubble contrast agents (Review). Mol Med Rep 12: 4022-4028, 2015.
APA
Ma, J., Xu, C.S., Gao, F., Chen, M., Li, F., & Du, L.F. (2015). Diagnostic and therapeutic research on ultrasound microbubble/nanobubble contrast agents (Review). Molecular Medicine Reports, 12, 4022-4028. https://doi.org/10.3892/mmr.2015.3941
MLA
Ma, J., Xu, C. S., Gao, F., Chen, M., Li, F., Du, L. F."Diagnostic and therapeutic research on ultrasound microbubble/nanobubble contrast agents (Review)". Molecular Medicine Reports 12.3 (2015): 4022-4028.
Chicago
Ma, J., Xu, C. S., Gao, F., Chen, M., Li, F., Du, L. F."Diagnostic and therapeutic research on ultrasound microbubble/nanobubble contrast agents (Review)". Molecular Medicine Reports 12, no. 3 (2015): 4022-4028. https://doi.org/10.3892/mmr.2015.3941
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