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Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion

  • Authors:
    • Lin Wu
    • Qing-Shan Zhao
    • Tian-Wei Li
    • Hai-Yuan Li
    • Qing‑Bi Wang
    • Xin-Ya Bi
    • Xin-Kun Cai
    • Nong Tang
  • View Affiliations / Copyright

    Affiliations: Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, P.R. China, Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 4273-4283
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    Published online on: June 18, 2015
       https://doi.org/10.3892/mmr.2015.3962
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Abstract

Apoptosis and the dysfunction of the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP-responsive element binding protein (CREB) signaling pathway have a key role in memory impairment in vascular dementia (VaD), a challenging clinical problem. Yifei Xuanfei Jiangzhuo formula (YXJF), a Chinese herbal decoction, has been used to treat VaD in clinical practice and has produced positive outcomes; however, convincing evidence is currently lacking. The present study aimed to investigate the effects of YXJF on memory impairment in rats with cerebral ischemia/reperfusion and to explore the underlying mechanism. YXJF ameliorated memory impairment in rats with cerebral ischemia/reperfusion, inhibited hippocampal apoptosis in a dose-dependent manner and attenuated increases in the protein expression of B-cell lymphoma 2 (Bcl-2)-associated X protein as well as c-Jun and a reduction in Bcl-2 protein expression in the hippocampal tissue of the rats. Furthermore, administration of YXJF significantly increased the protein expression of PKA C-α and CREB, and promoted CREB phosphorylation. The results indicated that YXJF improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion.
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Copy and paste a formatted citation
Spandidos Publications style
Wu L, Zhao Q, Li T, Li H, Wang QB, Bi X, Cai X and Tang N: Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion. Mol Med Rep 12: 4273-4283, 2015.
APA
Wu, L., Zhao, Q., Li, T., Li, H., Wang, Q., Bi, X. ... Tang, N. (2015). Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion. Molecular Medicine Reports, 12, 4273-4283. https://doi.org/10.3892/mmr.2015.3962
MLA
Wu, L., Zhao, Q., Li, T., Li, H., Wang, Q., Bi, X., Cai, X., Tang, N."Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion". Molecular Medicine Reports 12.3 (2015): 4273-4283.
Chicago
Wu, L., Zhao, Q., Li, T., Li, H., Wang, Q., Bi, X., Cai, X., Tang, N."Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion". Molecular Medicine Reports 12, no. 3 (2015): 4273-4283. https://doi.org/10.3892/mmr.2015.3962
Copy and paste a formatted citation
x
Spandidos Publications style
Wu L, Zhao Q, Li T, Li H, Wang QB, Bi X, Cai X and Tang N: Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion. Mol Med Rep 12: 4273-4283, 2015.
APA
Wu, L., Zhao, Q., Li, T., Li, H., Wang, Q., Bi, X. ... Tang, N. (2015). Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion. Molecular Medicine Reports, 12, 4273-4283. https://doi.org/10.3892/mmr.2015.3962
MLA
Wu, L., Zhao, Q., Li, T., Li, H., Wang, Q., Bi, X., Cai, X., Tang, N."Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion". Molecular Medicine Reports 12.3 (2015): 4273-4283.
Chicago
Wu, L., Zhao, Q., Li, T., Li, H., Wang, Q., Bi, X., Cai, X., Tang, N."Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion". Molecular Medicine Reports 12, no. 3 (2015): 4273-4283. https://doi.org/10.3892/mmr.2015.3962
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