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Article

Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats

  • Authors:
    • Wei Feng
    • Ruynag Teng
    • Yang Zhao
    • Jie Gao
    • Haichen Chu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266021, P.R. China
  • Pages: 4727-4733
    |
    Published online on: June 22, 2015
       https://doi.org/10.3892/mmr.2015.3972
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Abstract

Previous studies have demonstrated that the Wnt/β‑catenin signaling pathway is critical to the induction and maintenance of chronic neuropathic pain caused by peripheral inflammation and nerve damage. Emerging evidence from recent studies suggests that epigenetic mechanisms may also be critical to the pathogenesis of chronic pain. The present study aimed to elucidate the epigenetic mechanisms underlying altered Wnt signaling and their involvement in CCI‑induced neuropathic pain in rat sciatic nerves. The results of the present study demonstrated a significant increase in the expression levels of Wnt3a in the dorsal horn of the rats with CCI. In addition, a significant increase in histone H3 acetylation, and a significant decrease in cytosine methylation in the promoter region of Wnt3a was observed in the dorsal horn of the rats with CCI. Intrathecal application of XAV939, which acts as an inhibitor of Wnt signaling, significantly decreased the expression levels of active β‑catenin, and attenuated the rat behavioral responses to thermal and mechanical pain stimuli. These results suggest that the epigenetic upregulation of Wnt3a in the dorsal horn contributes to the maintenance of pain‑induced behavior in rats with CCI.
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Copy and paste a formatted citation
Spandidos Publications style
Feng W, Teng R, Zhao Y, Gao J and Chu H: Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats. Mol Med Rep 12: 4727-4733, 2015.
APA
Feng, W., Teng, R., Zhao, Y., Gao, J., & Chu, H. (2015). Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats. Molecular Medicine Reports, 12, 4727-4733. https://doi.org/10.3892/mmr.2015.3972
MLA
Feng, W., Teng, R., Zhao, Y., Gao, J., Chu, H."Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats". Molecular Medicine Reports 12.3 (2015): 4727-4733.
Chicago
Feng, W., Teng, R., Zhao, Y., Gao, J., Chu, H."Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats". Molecular Medicine Reports 12, no. 3 (2015): 4727-4733. https://doi.org/10.3892/mmr.2015.3972
Copy and paste a formatted citation
x
Spandidos Publications style
Feng W, Teng R, Zhao Y, Gao J and Chu H: Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats. Mol Med Rep 12: 4727-4733, 2015.
APA
Feng, W., Teng, R., Zhao, Y., Gao, J., & Chu, H. (2015). Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats. Molecular Medicine Reports, 12, 4727-4733. https://doi.org/10.3892/mmr.2015.3972
MLA
Feng, W., Teng, R., Zhao, Y., Gao, J., Chu, H."Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats". Molecular Medicine Reports 12.3 (2015): 4727-4733.
Chicago
Feng, W., Teng, R., Zhao, Y., Gao, J., Chu, H."Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats". Molecular Medicine Reports 12, no. 3 (2015): 4727-4733. https://doi.org/10.3892/mmr.2015.3972
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