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Article Open Access

Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas

  • Authors:
    • Ke Wang
    • Kaibing Tian
    • Liang Wang
    • Zhen Wu
    • Cong Ren
    • Shuyu Hao
    • Jie Feng
    • Junhua Li
    • Hong Wan
    • Guijun Jia
    • Liwei Zhang
    • Junting Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Skull Base and Brainstem Tumor Division, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing 100050, P.R. China, Beijing Neurosurgery Institute, Capital Medical University, Beijing 100050, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 4298-4304
    |
    Published online on: June 22, 2015
       https://doi.org/10.3892/mmr.2015.3976
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Abstract

Patients with skull base chordomas have a poor prognosis, and the role of the protein expression of brachyury in chordomas remains to be fully elucidated. The present study used immunohistochemistry to analyze 57 cases of skull base chordoma, and analyzed the clinical data of the patients. The results demonstrated that the protein expression of brachyury was negative in 8.8% (5/57) of the cases. The weak/positive, positive and strong/positive rates were 5.3% (3/57), 21.1% (12/57) and 64.9% (37/57), respectively. The association between the expression of brachyury and recurrence was not statistically significant. Kaplan‑Meier analysis revealed that the degree of surgery, rather than the expression of brachyury, was associated with tumor recurrence (P=0.001). In conclusion, the results of the present study demonstrated that the expression of Brachyury offers a sensitive marker, but not a risk factor, for skull base chordomas, and radical surgery is recommended.
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Copy and paste a formatted citation
Spandidos Publications style
Wang K, Tian K, Wang L, Wu Z, Ren C, Hao S, Feng J, Li J, Wan H, Jia G, Jia G, et al: Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas. Mol Med Rep 12: 4298-4304, 2015.
APA
Wang, K., Tian, K., Wang, L., Wu, Z., Ren, C., Hao, S. ... Zhang, J. (2015). Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas. Molecular Medicine Reports, 12, 4298-4304. https://doi.org/10.3892/mmr.2015.3976
MLA
Wang, K., Tian, K., Wang, L., Wu, Z., Ren, C., Hao, S., Feng, J., Li, J., Wan, H., Jia, G., Zhang, L., Zhang, J."Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas". Molecular Medicine Reports 12.3 (2015): 4298-4304.
Chicago
Wang, K., Tian, K., Wang, L., Wu, Z., Ren, C., Hao, S., Feng, J., Li, J., Wan, H., Jia, G., Zhang, L., Zhang, J."Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas". Molecular Medicine Reports 12, no. 3 (2015): 4298-4304. https://doi.org/10.3892/mmr.2015.3976
Copy and paste a formatted citation
x
Spandidos Publications style
Wang K, Tian K, Wang L, Wu Z, Ren C, Hao S, Feng J, Li J, Wan H, Jia G, Jia G, et al: Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas. Mol Med Rep 12: 4298-4304, 2015.
APA
Wang, K., Tian, K., Wang, L., Wu, Z., Ren, C., Hao, S. ... Zhang, J. (2015). Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas. Molecular Medicine Reports, 12, 4298-4304. https://doi.org/10.3892/mmr.2015.3976
MLA
Wang, K., Tian, K., Wang, L., Wu, Z., Ren, C., Hao, S., Feng, J., Li, J., Wan, H., Jia, G., Zhang, L., Zhang, J."Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas". Molecular Medicine Reports 12.3 (2015): 4298-4304.
Chicago
Wang, K., Tian, K., Wang, L., Wu, Z., Ren, C., Hao, S., Feng, J., Li, J., Wan, H., Jia, G., Zhang, L., Zhang, J."Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas". Molecular Medicine Reports 12, no. 3 (2015): 4298-4304. https://doi.org/10.3892/mmr.2015.3976
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