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Article

Genetic variation in the coagulation factor V gene and risk of femoral head osteonecrosis

  • Authors:
    • Tae‑Ho Kim
    • Seung‑Hoon Baek
    • Jeong Ok Lim
    • Sang‑Han Lee
    • Shin‑Yoon Kim
  • View Affiliations / Copyright

    Affiliations: Biomedical Research Institute, Kyungpook National University Hospital, Daegu 700‑721, Republic of Korea, Department of Orthopedic Surgery, Kyungpook National University Hospital, Daegu 700‑721, Republic of Korea, Department of Food Science and Biotechnology, Kyungpook National University, Daegu 702‑701, Republic of Korea, Skeletal Diseases Genome Research Center, Kyungpook National University, Daegu 700‑721, Republic of Korea
  • Pages: 4434-4440
    |
    Published online on: June 25, 2015
       https://doi.org/10.3892/mmr.2015.4000
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Abstract

Osteonecrosis of the femoral head (ONFH) is characterized by the death of the cellular portion of the femoral head due a reduction or disruption in the blood supply. Certain studies have implicated coagulation disorders, including thrombophilia and hypofibrinolysis, in the pathogenesis of ONFH. The factor V (F5) Leiden mutation has been suggested to be a genetic risk factor for venous thromboembolism and osteonecrosis in Caucasian individuals, however, this association remains controversial in other populations. The present study aimed to identify polymorphisms of the F5 gene and performed a case‑control study in a Korean population. The F5 gene was sequenced in 24 unrelated Korean individuals, and 16 polymorphisms were detected. A total of six polymorphisms were genotyped in 423 patients with ONFH and 348 control individuals. Analysis of the association between genotyped single nucleotide polymorphisms and haplotypes and with ONFH was performed. Comparison of the ONFH samples and the control individuals using logistic regression models revealed no statistically significant difference in the frequencies of the F5 polymorphisms and haplotypes. These findings suggested that F5 polymorphisms were not significant in the susceptibility to ONFH in the Korean population.
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Copy and paste a formatted citation
Spandidos Publications style
Kim TH, Baek SH, Lim JO, Lee SH and Kim SY: Genetic variation in the coagulation factor V gene and risk of femoral head osteonecrosis. Mol Med Rep 12: 4434-4440, 2015.
APA
Kim, T., Baek, S., Lim, J.O., Lee, S., & Kim, S. (2015). Genetic variation in the coagulation factor V gene and risk of femoral head osteonecrosis. Molecular Medicine Reports, 12, 4434-4440. https://doi.org/10.3892/mmr.2015.4000
MLA
Kim, T., Baek, S., Lim, J. O., Lee, S., Kim, S."Genetic variation in the coagulation factor V gene and risk of femoral head osteonecrosis". Molecular Medicine Reports 12.3 (2015): 4434-4440.
Chicago
Kim, T., Baek, S., Lim, J. O., Lee, S., Kim, S."Genetic variation in the coagulation factor V gene and risk of femoral head osteonecrosis". Molecular Medicine Reports 12, no. 3 (2015): 4434-4440. https://doi.org/10.3892/mmr.2015.4000
Copy and paste a formatted citation
x
Spandidos Publications style
Kim TH, Baek SH, Lim JO, Lee SH and Kim SY: Genetic variation in the coagulation factor V gene and risk of femoral head osteonecrosis. Mol Med Rep 12: 4434-4440, 2015.
APA
Kim, T., Baek, S., Lim, J.O., Lee, S., & Kim, S. (2015). Genetic variation in the coagulation factor V gene and risk of femoral head osteonecrosis. Molecular Medicine Reports, 12, 4434-4440. https://doi.org/10.3892/mmr.2015.4000
MLA
Kim, T., Baek, S., Lim, J. O., Lee, S., Kim, S."Genetic variation in the coagulation factor V gene and risk of femoral head osteonecrosis". Molecular Medicine Reports 12.3 (2015): 4434-4440.
Chicago
Kim, T., Baek, S., Lim, J. O., Lee, S., Kim, S."Genetic variation in the coagulation factor V gene and risk of femoral head osteonecrosis". Molecular Medicine Reports 12, no. 3 (2015): 4434-4440. https://doi.org/10.3892/mmr.2015.4000
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