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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-2015 Volume 12 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Case Report

A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review

  • Authors:
    • Chun‑Wei Xu
    • Xue‑Ying Cai
    • Yuan Shao
    • Yang Li
    • Ming‑Wei Shi
    • Li‑Ying Zhang
    • Lin Wang
    • Yu‑Ping Zhang
    • Lu‑Ping Wang
    • Yu‑Wang Tian
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China, Department of Internal Medicine, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang 312000, P.R. China, Department of Surgical Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Oncology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China
  • Pages: 4370-4375
    |
    Published online on: June 26, 2015
       https://doi.org/10.3892/mmr.2015.4001
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Abstract

The echinoderm microtubule associated protein like 4‑anaplastic lymphoma kinase (EML4‑ALK) fusion is almost mutually exclusive to epidermal growth factor receptor (EGFR) or K‑RAS mutation in non‑small cell lung cancer (NSCLC), and it is extremely rare for patients to exhibit both mutations. The present study reported the case of a 71-year‑old female diagnosed with adenocarcinoma, exhibiting mutations in EGFR and EML4‑ALK. The present study treated this patient with EGFR‑TK inhibitors, as the first line therapy, and gefitinib therapy revealed a good response until now. In addition, previously reported cases and associated literature were reviewed. The present study provided a greater understanding of the molecular biology and optimal treatment for patients with NSCLC with >1 driver mutation.
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1 

Zhou Q, Zhou CC, Chen GY, et al: A multicenter phase II study of sorafenib monotherapy in clinically selected patients with advanced lung adenocarcinoma after failure of EGFR-TKI therapy (Chinese Thoracic Oncology Group, CTONG 0805). Lung Cancer. 83:369–373. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Wang Z, Zhang X, Bai H, et al: EML4-ALK rearrangement and its clinical significance in Chinese patients with advanced non-small cell lung cancer. Oncology. 83:248–256. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Soda M, Choi YL, Enomoto M, et al: Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 448:561–566. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Inamura K, Takeuchi K, Togashi Y, et al: EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol. 3:13–17. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Koivunen JP, Mermel C, Zejnullahu K, et al: EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res. 14:4275–4283. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Yang J, Zhang X, Su J, et al: Concomitant EGFR mutation and EML4-ALK gene fusion in non-small cell lung cancer. J Clin Oncol. 29(Suppl): [abstr 10517]. 2011.

7 

Zhang X, Zhang S, Yang X, et al: Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression. Mol Cancer. 9:1882010. View Article : Google Scholar : PubMed/NCBI

8 

Kuo YW, Wu SG, Ho CC, et al: Good response to gefitinib in lung adenocarcinoma harboring coexisting EML4-ALK fusion gene and EGFR mutation. J Thorac Oncol. 5:2039–2040. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Tiseo M, Gelsomino F, Boggiani D, et al: EGFR and EML4-ALK gene mutations in NSCLC: A case report of erlotinib-resistant patient with both concomitant mutations. Lung Cancer. 71:241–243. 2011. View Article : Google Scholar

10 

Popat S, Vieira de Araújo A, Min T, et al: Lung adenocarcinoma with concurrent exon 19 EGFR mutation and ALK rearrangement responding to erlotinib. J Thorac Oncol. 6:1962–1963. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Tanaka H, Hayashi A, Morimoto T, et al: A case of lung adenocarcinoma harboring EGFR mutation and EML4-ALK fusion gene. BMC Cancer. 12:5582012. View Article : Google Scholar : PubMed/NCBI

12 

Santelmo C, Ravaioli A, Barzotti E, et al: Coexistence of EGFR mutation and ALK translocation in NSCLC: Literature review and case report of response to gefitinib. Lung Cancer. 81:294–296. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Chen X, Zhang J, Hu Q, et al: A case of lung adenocarcinoma harboring exon 19 EGFR deletion and EML4-ALK fusion gene. Lung Cancer. 81:308–310. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Shigematsu H, Lin L, Takahashi T, et al: Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 97:339–346. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Kosaka T, Yatabe Y, Endoh H, et al: Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications. Cancer Res. 64:8919–8923. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Li Y, Li Y, Yang T, et al: Clinical significance of EML4-ALK fusion gene and association with EGFR and KRAS gene mutations in 208 Chinese patients with non-small cell lung cancer. PLoS One. 8:e520932013. View Article : Google Scholar : PubMed/NCBI

17 

Gazdar AF, Shigematsu H, Herz J, et al: Mutations and addiction to EGFR: The Achilles 'heal' of lung cancers? Trends Mol Med. 10:481–486. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Inamura K, Takeuchi K, Togashi Y, et al: EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology and young onset. Mod Pathol. 22:508–515. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Martelli MP, Sozzi G, Hernandez L, et al: EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues. Am J Pathol. 174:661–670. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Shaw AT, Yeap BY, Mino-Kenudson M, et al: Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 27:4247–4253. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Wong DW, Leung EL, So KK, et al: The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer. 115:1723–1733. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Takahashi T, Sonobe M, Kobayashi M, et al: Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene. Ann Surg Oncol. 17:889–897. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Takeda M, Okamoto I, Sakai K, et al: Clinical outcome for EML4-ALK-positive patients with advanced non-small-cell lung cancer treated with first-line platinum-based chemotherapy. Ann Oncol. 23:2931–2936. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, Sunpaweravong P, Han B, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 361:947–957. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Zornosa C, Vandergrift JL, Kalemkerian GP, et al: First-line systemic therapy practice patterns and concordance with NCCN guidelines for patients diagnosed with metastatic NSCLC treated at NCCN institutions. J Natl Compr Canc Netw. 10:847–856. 2012.PubMed/NCBI

26 

Camidge DR, Bang YJ, Kwak EL, et al: Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer:updated results from a phase I study. Lancet Oncol. 13:1011–1019. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Sasaki T, Rodig SJ, Chirieac LR and Jänne PA: The biology and treatment of EML4-ALK non-small cell lung cancer. Eur J Cancer. 46:1773–1780. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu CW, Cai XY, Shao Y, Li Y, Shi MW, Zhang LY, Wang L, Zhang YP, Wang LP, Tian YW, Tian YW, et al: A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review. Mol Med Rep 12: 4370-4375, 2015.
APA
Xu, C., Cai, X., Shao, Y., Li, Y., Shi, M., Zhang, L. ... Tian, Y. (2015). A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review. Molecular Medicine Reports, 12, 4370-4375. https://doi.org/10.3892/mmr.2015.4001
MLA
Xu, C., Cai, X., Shao, Y., Li, Y., Shi, M., Zhang, L., Wang, L., Zhang, Y., Wang, L., Tian, Y."A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review". Molecular Medicine Reports 12.3 (2015): 4370-4375.
Chicago
Xu, C., Cai, X., Shao, Y., Li, Y., Shi, M., Zhang, L., Wang, L., Zhang, Y., Wang, L., Tian, Y."A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review". Molecular Medicine Reports 12, no. 3 (2015): 4370-4375. https://doi.org/10.3892/mmr.2015.4001
Copy and paste a formatted citation
x
Spandidos Publications style
Xu CW, Cai XY, Shao Y, Li Y, Shi MW, Zhang LY, Wang L, Zhang YP, Wang LP, Tian YW, Tian YW, et al: A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review. Mol Med Rep 12: 4370-4375, 2015.
APA
Xu, C., Cai, X., Shao, Y., Li, Y., Shi, M., Zhang, L. ... Tian, Y. (2015). A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review. Molecular Medicine Reports, 12, 4370-4375. https://doi.org/10.3892/mmr.2015.4001
MLA
Xu, C., Cai, X., Shao, Y., Li, Y., Shi, M., Zhang, L., Wang, L., Zhang, Y., Wang, L., Tian, Y."A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review". Molecular Medicine Reports 12.3 (2015): 4370-4375.
Chicago
Xu, C., Cai, X., Shao, Y., Li, Y., Shi, M., Zhang, L., Wang, L., Zhang, Y., Wang, L., Tian, Y."A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review". Molecular Medicine Reports 12, no. 3 (2015): 4370-4375. https://doi.org/10.3892/mmr.2015.4001
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