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Article Open Access

HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells

  • Authors:
    • Rui Ma
    • Dan Zhang
    • Peng-Chao Hu
    • Qun Li
    • Cong-Yao Lin
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center, Key Laboratory of Tumor Biological Behavior of Hubei, Wuhan, Hubei 430071, P.R. China, Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. China, Renmin Hospital of Wuhan University, The First College of Clinical Medicine of Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4901-4908
    |
    Published online on: July 1, 2015
       https://doi.org/10.3892/mmr.2015.4009
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Abstract

Homeobox B7 (HOXB7) has been found to be overexpressed in numerous types of human cancer. However, the role of HOXB7 in breast cancer remains to be elucidated. The aim of the present study was to investigate the effects of HOXB7 on the proliferation and invasion of breast cancer cells. Initially, reverse transcription quantitative polymerase chain reaction and western blotting were respectively employed to detect the mRNA and protein expression levels of the HOXB7 gene in the MDA‑MB‑231 and MCF‑7 human breast cancer cell lines. Subsequently, small interfering RNAs designed to interfere with the expression of HOXB7 were used to knockdown the expression of HOXB7 in the MCF‑7 cell line, the effects of which on cell proliferation, the apoptotic rate and invasion capacity were measured using a Cell Counting kit‑8 assay, flow cytometry and transwell chambers, respectively. The results demonstrated that HOXB7 mRNA and protein were all overexpressed in MDA‑MB‑231 and MCF‑7 breast cancer cell lines. Furthermore, HOXB7‑S3 effectively inhibited the proliferation and invasion of MCF‑7 breast cancer cells. In conclusion, these results demonstrated that HOXB7 may be a potential therapeutic target in human breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Ma R, Zhang D, Hu P, Li Q and Lin C: HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells. Mol Med Rep 12: 4901-4908, 2015.
APA
Ma, R., Zhang, D., Hu, P., Li, Q., & Lin, C. (2015). HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells. Molecular Medicine Reports, 12, 4901-4908. https://doi.org/10.3892/mmr.2015.4009
MLA
Ma, R., Zhang, D., Hu, P., Li, Q., Lin, C."HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells". Molecular Medicine Reports 12.4 (2015): 4901-4908.
Chicago
Ma, R., Zhang, D., Hu, P., Li, Q., Lin, C."HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells". Molecular Medicine Reports 12, no. 4 (2015): 4901-4908. https://doi.org/10.3892/mmr.2015.4009
Copy and paste a formatted citation
x
Spandidos Publications style
Ma R, Zhang D, Hu P, Li Q and Lin C: HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells. Mol Med Rep 12: 4901-4908, 2015.
APA
Ma, R., Zhang, D., Hu, P., Li, Q., & Lin, C. (2015). HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells. Molecular Medicine Reports, 12, 4901-4908. https://doi.org/10.3892/mmr.2015.4009
MLA
Ma, R., Zhang, D., Hu, P., Li, Q., Lin, C."HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells". Molecular Medicine Reports 12.4 (2015): 4901-4908.
Chicago
Ma, R., Zhang, D., Hu, P., Li, Q., Lin, C."HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells". Molecular Medicine Reports 12, no. 4 (2015): 4901-4908. https://doi.org/10.3892/mmr.2015.4009
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