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Article

Upregulation of microRNA‑335 and microRNA‑584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase

  • Authors:
    • Feng Jiang
    • Jipeng Li
    • Guojun Wu
    • Zhuo Miao
    • Linshan Lu
    • Guoping Ren
    • Xiaohong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China, Department of Gastrointestinal Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710033, P.R. China, Department of Urology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710033, P.R. China, Department of Hematology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China
  • Pages: 5383-5390
    |
    Published online on: July 2, 2015
       https://doi.org/10.3892/mmr.2015.4018
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Abstract

The aim of the present study was to identify the differentially expressed microRNAs (miRNAs) in placenta from patients with preeclampsia, and examine their roles in the pathogenesis of preeclampsia in vivo and ex vivo. The placental expression levels of miRNAs were examined in tissue samples harvested from 20 patients with preeclampsia and 20 healthy control individuals. A total of 18 miRNAs were differentially expressed (12 upregulated and six downregulated) among the preeclampsia cases, compared with the controls. By further functional/pathway analysis, two significantly upregulated miRNAs, miR‑335 and miR‑584, were identified. These target endothelial nitric oxide synthase (eNOS), which has been repeatedly reported to be involved in the development of preeclampsia. The present study then verified eNOS as a target gene of miR‑335 and miR‑584 using a luceriferase assay, and confirmed the expression patterns of the two miRNAs and eNOS in preeclampsic and normal placentas. Additionally, to examine the function of miR‑584 and miR‑335 in human placenta, the present study transiently transfected the HTR8/Svneo cell line with miR‑584 and miR‑335 mimics or their inhibitors, and the results of a subsequent Transwell insert invasion assay revealed that miR‑584 and miR‑335 inhibited the migratory ability of the trophoblast cells, and that the effect was ‘rescued' by overexpressed eNOS. These data revealed a negative regulatory role of miR‑584 and miR‑335 in the migration of HTR‑8/SVneo cells by targeting eNOS, and identified miR‑584 and miR‑335 as potential novel therapeutic targets in preeclampsia.
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1 

Sibai B, Dekker G and Kupferminc M: Pre-eclampsia. Lancet. 365:785–799. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Redman CW and Sargent IL: Latest advances in understanding preeclampsia. Science. 308:1592–1594. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Grill S, Rusterholz C, Zanetti-Dallenbach R, Tercanli S, Holzgreve W, Hahn S and Lapaire O: Potential markers of preeclampsia-a review. Reprod Biol Endocrinol. 7:702009. View Article : Google Scholar

4 

Huppertz B: Placental origins of preeclampsia: Challenging the current hypothesis. Hypertension. 51:970–975. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Oudejans CB and van Dijk M: Placental gene expression and pre-eclampsia. Placenta. 29(Suppl A): S78–S82. 2008. View Article : Google Scholar

6 

Sitras V, Paulssen RH, Grønaas H, Leirvik J, Hanssen TA, Vårtun A and Acharya G: Differential placental gene expression in severe preeclampsia. Placenta. 30:424–433. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Founds SA, Conley YP, Lyons-Weiler JF, Jeyabalan A, Hogge WA and Conrad KP: Altered global gene expression in first trimester placentas of women destined to develop preeclampsia. Placenta. 30:15–24. 2009. View Article : Google Scholar :

8 

Enquobahrie DA, Meller M, Rice K, Psaty BM, Siscovick DS and Williams MA: Differential placental gene expression in preeclampsia. Am J Obstet Gynecol. 199:566e561–e511. 2008.PubMed/NCBI

9 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Yu J, Wang F, Yang GH, Wang FL, Ma YN, Du ZW and Zhang JW: Human microRNA clusters: Genomic organization and expression profile in leukemia cell lines. Biochem Bioph Res Commun. 349:59–68. 2006. View Article : Google Scholar

11 

Brennecke J, Hipfner DR, Stark A, Russell RB and Cohen SM: bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell. 113:25–36. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Calame K: MicroRNA-155 function in B Cells. Immunity. 27:825–827. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Jopling CL, Yi M, Lancaster AM, Lemon SM and Sarnow P: Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science. 309:1577–1581. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Hu Y, Li P, Hao S, Liu L, Zhao J and Hou Y: Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia. Clin Chem Lab Med. 47:923–929. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Mouillet JF, Chu T, Nelson DM, Mishima T and Sadovsky Y: MiR-205 silences MED1 in hypoxic primary human trophoblasts. FASEB J. 24:2030–2039. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Skrzypek K, Tertil M, Golda S, Ciesla M, Weglarczyk K, Collet G, Guichard A, Kozakowska M, Boczkowski J, Was H, et al: Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization and metastasis. Antioxid Redox Signal. 19:644–660. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Chen LT, Xu SD, Xu H, Zhang JF, Ning JF and Wang SF: MicroRNA-378 is associated with non-small cell lung cancer brain metastasis by promoting cell migration, invasion and tumor angiogenesis. Med Oncol. 29:1673–1680. 2012. View Article : Google Scholar

18 

Corthorn J, Germain AA, Chacón C, Rey S, Soto GX, Figueroa CD, Müller-Esterl W, Duarte I and Valdés G: Expression of kallikrein, bradykinin b2 receptor and endothelial nitric oxide synthase in placenta in normal gestation, preeclampsia and placenta accreta. Endocrine. 29:491–499. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Li F, Hagaman JR, Kim HS, Maeda N, Jennette JC, Faber JE, Karumanchi SA, Smithies O and Takahashi N: eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype. J Am Soc Nephrol. 23:652–660. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, et al: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 105:10513–10518. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Chim SS, Shing TK, Hung EC, Leung TY, Lau TK, Chiu RW and Lo YM: Detection and characterization of placental microRNAs in maternal plasma. Clin Chem. 54:482–490. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Gilad S, Meiri E, Yogev Y, Benjamin S, Lebanony D, Yerushalmi N, Benjamin H, Kushnir M, Cholakh H, Melamed N, et al: Serum microRNAs are promising novel biomarkers. PLoS One. 3:e31482008. View Article : Google Scholar : PubMed/NCBI

23 

Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, Hood LE and Galas DJ: Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci USA. 106:4402–4407. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Sibai B, Dekker G and Kupferminc M: Pre-eclampsia. Lancet. 365:785–799. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, et al: CPEP Study Group: Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med. 355:992–1005. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Myatt L: Role of placenta in preeclampsia. Endocrine. 19:103–111. 2002. View Article : Google Scholar

27 

Maynard S, Epstein FH and Karumanchi SA: Preeclampsia and angiogenic imbalance. Annu Rev Med. 59:61–78. 2008. View Article : Google Scholar

28 

Pineles BL, Romero R, Montenegro D, Tarca AL, Han YM, Kim YM, Draghici S, Espinoza J, Kusanovic JP, Mittal P, et al: Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia. Am J Obstet Gynecol. 196:261e261–e266. 2007.PubMed/NCBI

29 

Roman H, Marpeau L and Hulsey TC: Surgeons' experience and interaction effect in randomized controlled trials regarding new surgical procedures. Am J Obstet Gynecol. 199:108e101–e106. 2008.PubMed/NCBI

30 

Hu Y, Li P, Hao S, Liu L, Zhao J and Hou Y: Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia. Clin Chem Lab Med. 47:923–929. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Guo G, Lade JA, Wilton AN, Moses EK, Grehan M, Fu Y, Qiu H, Cooper DW and Brennecke SP: Genetic susceptibility to pre-eclampsia and chromosome 7q36. Hum Genet. 105:641–647. 1999. View Article : Google Scholar

32 

Demircubuk AG, Coskun MY, Demiryurek S, Dokuyucu R, Öztuzcu S, Taviloğlu ZŞ, Arslan A and Sivaslı E: Endothelial NOS gene Glu298Asp polymorphism in preterm neonates with respiratory distress syndrome. Pediatr Pulmonol. 48:976–980. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Duplain H, Burcelin R, Sartori C, Cook S, Egli M, Lepori M, Vollenweider P, Pedrazzini T, Nicod P, Thorens B, et al: Insulin resistance, hyperlipidemia and hypertension in mice lacking endothelial nitric oxide synthase. Circulation. 104:342–345. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Xiang W, Chen H, Hu L and Xu X: Endothelial nitric oxide synthase traffic inducer in the umbilical vessels of the patients with pre-eclampsia. J Huazhong U Sci Technolog Med Sci. 29:243–245. 2009. View Article : Google Scholar

35 

Soundararajan R and Rao AJ: Trophoblast 'pseudo-tumorigenesis': Significance and contributory factors. Reprod Biol Endocrinol. 2:152004. View Article : Google Scholar : PubMed/NCBI

36 

Lala PK and Chakraborty C: Factors regulating trophoblast migration and invasiveness: Possible derangements contributing to pre-eclampsia and fetal injury. Placenta. 24:575–587. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Buhimschi I, Yallampalli C, Chwalisz K and Garfield RE: Pre-eclampsia-like conditions produced by nitric oxide inhibition: Effects of L-arginine, D-arginine and steroid hormones. Hum Reprod. 10:2723–2730. 1995.PubMed/NCBI

38 

Enquobahrie DA, Abetew DF, Sorensen TK, Willoughby D, Chidambaram K and Williams MA: Placental microRNA expression in pregnancies complicated by preeclampsia. Am J Obstet Gynecol. 204:178e112–e121. 2011.

39 

Wang H, Li M, Zhang R, Wang Y, Zang W, Ma Y, Zhao G and Zhang G: Effect of miR-335 upregulation on the apoptosis and invasion of lung cancer cell A549 and H1299. Tumour Biol. 34:3101–3109. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Ueno K, Hirata H, Shahryari V, Chen Y, Zaman MS, Singh K, Tabatabai ZL, Hinoda Y and Dahiya R: Tumour suppressor microRNA-584 directly targets oncogene Rock-1 and decreases invasion ability in human clear cell renal cell carcinoma. Br J Cancer. 104:308–315. 2011. View Article : Google Scholar :

41 

Caterina MJ and Devreotes PN: Molecular insights into eukaryotic chemotaxis. FASEB J. 5:3078–3085. 1991.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang F, Li J, Wu G, Miao Z, Lu L, Ren G and Wang X: Upregulation of microRNA‑335 and microRNA‑584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase. Mol Med Rep 12: 5383-5390, 2015.
APA
Jiang, F., Li, J., Wu, G., Miao, Z., Lu, L., Ren, G., & Wang, X. (2015). Upregulation of microRNA‑335 and microRNA‑584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase. Molecular Medicine Reports, 12, 5383-5390. https://doi.org/10.3892/mmr.2015.4018
MLA
Jiang, F., Li, J., Wu, G., Miao, Z., Lu, L., Ren, G., Wang, X."Upregulation of microRNA‑335 and microRNA‑584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase". Molecular Medicine Reports 12.4 (2015): 5383-5390.
Chicago
Jiang, F., Li, J., Wu, G., Miao, Z., Lu, L., Ren, G., Wang, X."Upregulation of microRNA‑335 and microRNA‑584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase". Molecular Medicine Reports 12, no. 4 (2015): 5383-5390. https://doi.org/10.3892/mmr.2015.4018
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang F, Li J, Wu G, Miao Z, Lu L, Ren G and Wang X: Upregulation of microRNA‑335 and microRNA‑584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase. Mol Med Rep 12: 5383-5390, 2015.
APA
Jiang, F., Li, J., Wu, G., Miao, Z., Lu, L., Ren, G., & Wang, X. (2015). Upregulation of microRNA‑335 and microRNA‑584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase. Molecular Medicine Reports, 12, 5383-5390. https://doi.org/10.3892/mmr.2015.4018
MLA
Jiang, F., Li, J., Wu, G., Miao, Z., Lu, L., Ren, G., Wang, X."Upregulation of microRNA‑335 and microRNA‑584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase". Molecular Medicine Reports 12.4 (2015): 5383-5390.
Chicago
Jiang, F., Li, J., Wu, G., Miao, Z., Lu, L., Ren, G., Wang, X."Upregulation of microRNA‑335 and microRNA‑584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase". Molecular Medicine Reports 12, no. 4 (2015): 5383-5390. https://doi.org/10.3892/mmr.2015.4018
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