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Article

Increased expression of Notch 1 in a rat liver transplantation model

  • Authors:
    • Lihong Chen
    • Wubing He
    • Kaida Huang
    • Lin Zheng
    • Lingyun Gao
    • Jingfeng Liu
    • Aimin Huang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Basic Medical Sciences of Fujian Medical University, Fuzhou, Fujian 350004, P.R. China, Provincial Clinical Medical College, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China, Department of Pathology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, P.R. China
  • Pages: 5293-5297
    |
    Published online on: July 2, 2015
       https://doi.org/10.3892/mmr.2015.4026
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Abstract

Liver transplantation is the standard treatment for end‑stage liver failure; however, rejection can result in allograft failure. In order to investigate the role of Notch 1 during rejection, the present study evaluated Notch 1 expression, as well as the levels of immune reactivity, in rat liver allografts. A heterotopic liver transplantation model was established using Dark Agouti (DA) rats as donors and Lewis rats as recipients (DA/Lewis), with DA recipient rats serving as controls (DA/DA). The concentration levels of immune reactivity markers and serum Notch 1 were measured on days 3, 5, and 7. The overall survival was significantly shorter (<10 days) in the DA/Lewis group, as compared with the DA/DA group (P<0.0001). The concentration levels of serum alanine aminotransferase and total bilirubin were significantly higher 5 and 7 days following transplantation in the DA/Lewis group, as compared with the DA/DA group (P<0.001). The concentration levels of serum Notch 1 were significantly higher in the DA/Lewis group, as compared with the DA/DA group on days 3, 5, and 7 following transplantation (P<0.0001). These results indicate that the expression levels of serum Notch 1 significantly increase during liver allograft rejection, suggesting that Notch 1 is involved in the mechanism underlying liver allograft rejection. Notch 1 may serve as a marker of acute rejection in a rat liver transplantation model.
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Copy and paste a formatted citation
Spandidos Publications style
Chen L, He W, Huang K, Zheng L, Gao L, Liu J and Huang A: Increased expression of Notch 1 in a rat liver transplantation model. Mol Med Rep 12: 5293-5297, 2015.
APA
Chen, L., He, W., Huang, K., Zheng, L., Gao, L., Liu, J., & Huang, A. (2015). Increased expression of Notch 1 in a rat liver transplantation model. Molecular Medicine Reports, 12, 5293-5297. https://doi.org/10.3892/mmr.2015.4026
MLA
Chen, L., He, W., Huang, K., Zheng, L., Gao, L., Liu, J., Huang, A."Increased expression of Notch 1 in a rat liver transplantation model". Molecular Medicine Reports 12.4 (2015): 5293-5297.
Chicago
Chen, L., He, W., Huang, K., Zheng, L., Gao, L., Liu, J., Huang, A."Increased expression of Notch 1 in a rat liver transplantation model". Molecular Medicine Reports 12, no. 4 (2015): 5293-5297. https://doi.org/10.3892/mmr.2015.4026
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, He W, Huang K, Zheng L, Gao L, Liu J and Huang A: Increased expression of Notch 1 in a rat liver transplantation model. Mol Med Rep 12: 5293-5297, 2015.
APA
Chen, L., He, W., Huang, K., Zheng, L., Gao, L., Liu, J., & Huang, A. (2015). Increased expression of Notch 1 in a rat liver transplantation model. Molecular Medicine Reports, 12, 5293-5297. https://doi.org/10.3892/mmr.2015.4026
MLA
Chen, L., He, W., Huang, K., Zheng, L., Gao, L., Liu, J., Huang, A."Increased expression of Notch 1 in a rat liver transplantation model". Molecular Medicine Reports 12.4 (2015): 5293-5297.
Chicago
Chen, L., He, W., Huang, K., Zheng, L., Gao, L., Liu, J., Huang, A."Increased expression of Notch 1 in a rat liver transplantation model". Molecular Medicine Reports 12, no. 4 (2015): 5293-5297. https://doi.org/10.3892/mmr.2015.4026
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