Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2015 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2015 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Bioinformatics analysis to identify the differentially expressed genes of glaucoma

  • Authors:
    • Xiang Yan
    • Fei Yuan
    • Xiuping Chen
    • Chunqiong Dong
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Pudong District Gongli Hospital, Shanghai 200135, P.R. China, Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4829-4836
    |
    Published online on: July 2, 2015
       https://doi.org/10.3892/mmr.2015.4030
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to screen the differentially expressed genes (DEGs) associated with glaucoma and investigate the changing patterns of the expression of these genes. The GSE2378 gene microarray data of glaucoma was downloaded from the Gene Expression Omnibus database, which included seven normal samples and eight glaucoma astrocyte samples. Taking into account the corresponding associations between the probe ID and gene symbols, the DEGs were identified prior to and subsequent to the summation of probe level values using the Limma package in R language, followed by Gene Ontology (GO) and pathway enrichment analyses. Interaction networks of the DEGs were constructed using the Biomolecular Interaction Network Database, and cluster analysis of the genes in the networks was performed using ClusterONE. Subsequent to the summation of probe value, a total of 223 genes were identified as DEGs between the normal and glaucoma samples, including 74 downregulated and 149 upregulated genes. In addition, the DEGs were found to be associated with several functions, including response to wounding, extracellular region part and calcium ion binding. The most significantly enriched pathways were complement and coagulation cascades, arrhythmogenic right ventricular cardiomyopathy and extracellular matrix (ECM)‑receptor interaction. Furthermore, interaction networks were constructed of the DEGs prior to and subsequent to the summation of probe values, and HNF4A and CEBPD were identified as hub genes. Additionally, 37 and 31 GO terms were identified to be enriched in the two DEGs of the networks prior to and subsequent to summation, respectively. The results indicated the identified genes associated with ECM as important, and the CEBPD gene was considered to be a critical gene in glaucoma. The findings of the present study offer a potential reference value in further investigations of glaucoma at the gene level.
View Figures

Figure 1

Figure 2

View References

1 

Quigley HA and Broman AT: The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 90:262–267. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Tham YC, Li X, Wong TY, Quigley HA, Aung T and Cheng CY: Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis. Ophthalmology. 121:2081–2090. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Caprioli J and Coleman AL: Intraocular pressure fluctuation a risk factor for visual field progression at low intraocular pressures in the advanced glaucoma intervention study. Opthalmology. 115:1123–1129. 2008. View Article : Google Scholar

4 

Rudzinski MN, Chen L and Hernandez MR: Antiangiogenic characteristics of astrocytes from optic nerve heads with primary open-angle glaucoma. Arch Ophthalmol. 126:679–685. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Quigley HA: Neuronal death in glaucoma. Prog Retin Eye Res. 18:39–57. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Hernandez MR: The optic nerve head in glaucoma: Role of astrocytes in tissue remodeling. Prog Retin Eye Res. 19:297–321. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Varela HJ and Hernandez MR: Astrocyte responses in human optic nerve head with primary open-angle glaucoma. J Glaucoma. 6:303–313. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Liu B, Chen H, Johns TG and Neufeld AH: Epidermal growth factor receptor activation: An upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury. J Neurosci. 26:7532–7540. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Fingert JH: Primary open-angle glaucoma genes. Eye (Lond). 25:587–595. 2011. View Article : Google Scholar

10 

Horsley MB and Kahook MY: Anti-VEGF therapy for glaucoma. Curr Opin Ophthalmol. 21:112–117. 2010. View Article : Google Scholar

11 

Miller JW: Vascular endothelial growth factor and ocular neovascularization. Am J Pathol. 151:13–23. 1997.PubMed/NCBI

12 

Shima DT, Adamis AP, Ferrara N, et al: Hypoxic induction of endothelial cell growth factors in retinal cells: Identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Mol Med. 1:182–193. 1995.PubMed/NCBI

13 

Ramazanoglu M, Lutz R, Ergun C, von Wilmowsky C, Nkenke E and Schlegel KA: The effect of combined delivery of recombinant human bone morphogenetic protein-2 and recombinant human vascular endothelial growth factor 165 from biomimetic calcium-phosphate-coated implants on osseointegration. Clin Oral Implants Res. 22:1433–1439. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Binder DR, Herring IP, Zimmerman KL, Pickett JP and Huckle WR: Expression of vascular endothelial growth factor receptor-1 and-2 in normal and diseased canine eyes. Vet Ophthalmol. 15:223–230. 2012. View Article : Google Scholar

15 

Chatterjee S, Wang Y, Duncan MK and Naik UP: Junctional adhesion molecule-A regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing. PloS One. 8:e636742013. View Article : Google Scholar : PubMed/NCBI

16 

Vithana EN, Aung T, Khor CC, et al: Collagen-related genes influence the glaucoma risk factor, central corneal thickness. Hum Mol Genet. 20:649–658. 2011. View Article : Google Scholar

17 

Desronvil T, Logan-Wyatt D, Abradou W, et al: Distribution of COL8A2 and COL8A1 gene variants in Caucasian primary open angle glaucoma patients with thin central corneal thickness. Mol Vis. 16:2185–2191. 2010.PubMed/NCBI

18 

Huang W, Fan Q, Wang W, Zhou M, Laties AM and Zhang X: Collagen: A potential factor involved in the pathogenesis of glaucoma. Med Sci Monit Basic Res. 19:237–240. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Liu X, Brandt CR, Rasmussen CA and Kaufman PL: Glaucoma gene therapy. Expert Rev Ophthalmol. 2:227–236. 2007. View Article : Google Scholar

20 

Bettahi I, Sun H, Gao N, et al: Genome-wide transcriptional analysis of differentially expressed genes in diabetic, healing corneal epithelial cells: Hyperglycemia-suppressed TGFβ3 expression contributes to the delay of epithelial wound healing in diabetic corneas. Diabetes. 63:715–727. 2014. View Article : Google Scholar :

21 

Pieragostino D, Bucci S, Agnifili L, et al: Differential protein expression in tears of patients with primary open angle and pseudoexfoliative glaucoma. Mol Biosyst. 8:1017–1028. 2012. View Article : Google Scholar

22 

Colak D, Morales J, Bosley TM, et al: Genome-wide expression profiling of patients with primary open angle glaucoma. Invest Ophthalmol Vis Sci. 53:5899–5904. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Liao Q, Sun X, Guo H and Li C: Exploring the potential mechanism and screening small molecule drugs for glaucoma by using bioinformatics approach. Eur Rev Med Pharmacol Sci. 18:132–140. 2014.PubMed/NCBI

24 

Shi WY, Liu KD, Xu SG, et al: Gene expression analysis of lung cancer. Eur Rev Med Pharmacol Sci. 18:217–228. 2014.PubMed/NCBI

25 

Liu T, Xie L, Ye J and He X: Family-based analysis identified CD2 as a susceptibility gene for primary open angle glaucoma in Chinese Han population. J Cell Mol Med. 18:600–609. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Hernandez MR, Agapova OA, Yang P, Salvador-Silva M, Ricard CS and Aoi S: Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray. Glia. 38:45–64. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Kompass KS, Agapova OA, Li W, Kaufman PL, Rasmussen CA and Hernandez MR: Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension. BMC Neurosci. 9:932008. View Article : Google Scholar : PubMed/NCBI

28 

Edgar R, Domrachev M and Lash AE: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar :

29 

Chang-Zheng L, Xue-Hai M, Jin Z, et al: Posterior indirect-decompression technique versus posterior direct vision decompression for thoracolumbar burst fractures. Journal of Clinical Rehabilitative Tissue Engineering Research. 15:2011.

30 

Troyanskaya O, Cantor M, Sherlock G, et al: Missing value estimation methods for DNA microarrays. Bioinformatics. 17:520–525. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Fujita A, Sato JR, Rodrigues Lde O, Ferreira CE and Sogayar MC: Evaluating different methods of microarray data normalization. BMC Bioinformatics. 7:4692006. View Article : Google Scholar : PubMed/NCBI

32 

Smyth GK: Limma: Linear models for microarray data. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Gentleman R, Carey V, Huber W, Irizarry R and Dudoit S: Springer; New York: pp. 397–420. 2005, View Article : Google Scholar

33 

Zheng Q and Wang XJ: GOEAST: A web-based software toolkit for Gene Ontology enrichment analysis. Nucleic Acids Res. 36(Web Server Issue): W358–W363. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Huang da W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar :

35 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2008. View Article : Google Scholar

36 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar

37 

Bader GD, Betel D and Hogue CW: BIND: The biomolecular interaction network database. Nucleic Acids Res. 31:248–250. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Lee CH, Lee JM, Wu DC, et al: Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. Int J Cancer. 122:1347–1356. 2008. View Article : Google Scholar

39 

Yasuhara T, Okamoto A, Kitagawa T, et al: FGF7-like gene is associated with pericentric inversion of chromosome 9 and FGF7 is involved in the development of ovarian cancer. Int J Oncol. 26:1209–1216. 2005.PubMed/NCBI

40 

Yu JT, Li L, Zhu QX, et al: Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease. Clin Chim Acta. 411:1516–1519. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Schlott T, Eiffert H, Bohne W, et al: Chlamydia trachomatis modulates expression of tumor suppressor gene caveolin-1 and oncogene C-myc in the transformation zone of non-neoplastic cervical tissue. Gynecol Oncol. 98:409–419. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Méplan C, Hughes DJ, Pardini B, et al: Genetic variants in selenoprotein genes increase risk of colorectal cancer. Carcinogenesis. 31:1074–1079. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Abusnina A, Keravis T, Yougbaré I, Bronner C and Lugnier C: Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1. Mol Nutr Food Res. 55:1677–1689. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Mansberger SL, MacKenzie PJ and Falardeau J: Optic disc cupping associated with neurosyphilis. J Glaucoma. 22:80–83. 2013. View Article : Google Scholar

45 

Kirwan RP, Wordinger RJ, Clark AF and O'Brien CJ: Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells. Mol Vis. 15:76–88. 2009.PubMed/NCBI

46 

Odom DT, Zizlsperger N, Gordon DB, et al: Control of pancreas and liver gene expression by HNF transcription factors. Science. 303:1378–1381. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Edghill EL and Hattersley AT: Genetic disorders of the pancreatic beta cell and diabetes (permanent neonatal diabetes and maturity-onset diabetes of the young). Pancreatic Beta Cell in Health and Disease. Seino S and Bell GI: Springer; Japan, Tokyo, Japan: pp. 399–430. 2008, View Article : Google Scholar

48 

Ramji DP and Foka P: CCAAT/enhancer-binding proteins: Structure, function and regulation. Biochem J. 365:561–575. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Johnson PF: Molecular stop signs: Regulation of cell-cycle arrest by C/EBP transcription factors. J Cell Sci. 118:2545–2555. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Johnson EC, Doser TA, Cepurna WO, et al: Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma. Invest Ophthalmol Vis Sci. 52:504–518. 2011. View Article : Google Scholar :

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yan X, Yuan F, Chen X and Dong C: Bioinformatics analysis to identify the differentially expressed genes of glaucoma. Mol Med Rep 12: 4829-4836, 2015.
APA
Yan, X., Yuan, F., Chen, X., & Dong, C. (2015). Bioinformatics analysis to identify the differentially expressed genes of glaucoma. Molecular Medicine Reports, 12, 4829-4836. https://doi.org/10.3892/mmr.2015.4030
MLA
Yan, X., Yuan, F., Chen, X., Dong, C."Bioinformatics analysis to identify the differentially expressed genes of glaucoma". Molecular Medicine Reports 12.4 (2015): 4829-4836.
Chicago
Yan, X., Yuan, F., Chen, X., Dong, C."Bioinformatics analysis to identify the differentially expressed genes of glaucoma". Molecular Medicine Reports 12, no. 4 (2015): 4829-4836. https://doi.org/10.3892/mmr.2015.4030
Copy and paste a formatted citation
x
Spandidos Publications style
Yan X, Yuan F, Chen X and Dong C: Bioinformatics analysis to identify the differentially expressed genes of glaucoma. Mol Med Rep 12: 4829-4836, 2015.
APA
Yan, X., Yuan, F., Chen, X., & Dong, C. (2015). Bioinformatics analysis to identify the differentially expressed genes of glaucoma. Molecular Medicine Reports, 12, 4829-4836. https://doi.org/10.3892/mmr.2015.4030
MLA
Yan, X., Yuan, F., Chen, X., Dong, C."Bioinformatics analysis to identify the differentially expressed genes of glaucoma". Molecular Medicine Reports 12.4 (2015): 4829-4836.
Chicago
Yan, X., Yuan, F., Chen, X., Dong, C."Bioinformatics analysis to identify the differentially expressed genes of glaucoma". Molecular Medicine Reports 12, no. 4 (2015): 4829-4836. https://doi.org/10.3892/mmr.2015.4030
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team