MicroRNA-7 inhibits the malignant phenotypes of non‑small cell lung cancer in vitro by targeting Pax6

Retraction in: /10.3892/mmr.2021.12343

  • Authors:
    • Jiashun Luo
    • Hui Li
    • Chunfang Zhang
  • View Affiliations

  • Published online on: July 2, 2015     https://doi.org/10.3892/mmr.2015.4032
  • Pages: 5443-5448
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Abstract

MicroRNA (miR)-7 has been reported to act as a suppressor in several types of cancer, including non-small cell lung cancer (NSCLC). In addition, paired box 6 (Pax6), a highly conserved transcriptional factor, has been implicated in NSCLC. However, the exact role of miR-7, and the association between miR-7 and Pax6 in NSCLC cells remain to be fully elucidated. The present study demonstrated that miR-7 was downregulated and Pax6 was upregulated in NSCLC cell lines. Subsequently, it was demonstrated that overexpression of miR-7 notably inhibited the protein expression of Pax6, while inhibition of miR-7 enhanced the protein expression of Pax6 in NSCLC A549 cells. Further investigation identified Pax6 as a target of miR-7 in A549 NSCLC cells. Ina ddition, the overexpression of miR-7 significantly inhibited A549 cell proliferation and invasion, which was reversed by upregulation of Pax6. Investigation of the underlying molecular mechanism revealed that the extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) signaling pathways were downregulated in the miR-7-overexpressed A549 cells, but were activated in the Pax6-overexpressed A549 cells. Based on these findings, it was suggested that miR-7 negatively regulates the protein level of Pax6, which can promote the proliferation and invasion of NSCLC cells via activation of the ERK and MAPK signaling pathways. Therefore, miR-7/Pax6 may offer potential for use as a target for the treatment of NSCLC.
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October-2015
Volume 12 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Luo J, Li H and Zhang C: MicroRNA-7 inhibits the malignant phenotypes of non‑small cell lung cancer in vitro by targeting Pax6 Retraction in /10.3892/mmr.2021.12343. Mol Med Rep 12: 5443-5448, 2015
APA
Luo, J., Li, H., & Zhang, C. (2015). MicroRNA-7 inhibits the malignant phenotypes of non‑small cell lung cancer in vitro by targeting Pax6 Retraction in /10.3892/mmr.2021.12343. Molecular Medicine Reports, 12, 5443-5448. https://doi.org/10.3892/mmr.2015.4032
MLA
Luo, J., Li, H., Zhang, C."MicroRNA-7 inhibits the malignant phenotypes of non‑small cell lung cancer in vitro by targeting Pax6 Retraction in /10.3892/mmr.2021.12343". Molecular Medicine Reports 12.4 (2015): 5443-5448.
Chicago
Luo, J., Li, H., Zhang, C."MicroRNA-7 inhibits the malignant phenotypes of non‑small cell lung cancer in vitro by targeting Pax6 Retraction in /10.3892/mmr.2021.12343". Molecular Medicine Reports 12, no. 4 (2015): 5443-5448. https://doi.org/10.3892/mmr.2015.4032