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Article

Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells

  • Authors:
    • Mingyue Xiong
    • Liqiang Liu
    • Zhenhui Liu
    • Hangfei Gao
  • View Affiliations / Copyright

    Affiliations: Department of Traumatic Surgery, Xinqu Hospital, The First Affiliated Hospital of Henan University of Science Technology, Luoyang, Henan 471000, P.R. China
  • Pages: 5286-5292
    |
    Published online on: July 17, 2015
       https://doi.org/10.3892/mmr.2015.4088
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Abstract

Osteoporosis and diabetes have become serious health problems worldwide. Previous studies have suggested that diabetes is associated with osteoporosis and increased fracture risk. However, the mechanism underlying diabetes‑induced osteoporosis remains to be elucidated. Therefore, the present study aimed to examine the mechanism underlying diabetes‑induced osteoporosis, and determine the protective effects of zinc, which is known to be closely associated with osteoporosis and diabetes. The results of the present study demonstrated that zinc inhibited advanced glycation end product (AGE)‑induced MC3T3‑E1 cell apoptosis by attenuating the production of reactive oxygen species, inhibiting caspase‑3 and caspase‑9 activation, and inhibiting the release of cytochrome c from between the mitochondria and the cytosol. Furthermore, zinc was found to protect cells against AGE‑induced apoptosis via the mitogen‑activated protein kinase/extracellular signal‑regulated kinase and phosphoinositide 3‑kinase/AKT signaling pathways. In conclusion, these findings enable a better understanding of the mechanism underlying diabetes‑induced osteoporosis, and may indicate a novel target for its prevention and treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Xiong M, Liu L, Liu Z and Gao H: Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells. Mol Med Rep 12: 5286-5292, 2015.
APA
Xiong, M., Liu, L., Liu, Z., & Gao, H. (2015). Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells. Molecular Medicine Reports, 12, 5286-5292. https://doi.org/10.3892/mmr.2015.4088
MLA
Xiong, M., Liu, L., Liu, Z., Gao, H."Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells". Molecular Medicine Reports 12.4 (2015): 5286-5292.
Chicago
Xiong, M., Liu, L., Liu, Z., Gao, H."Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells". Molecular Medicine Reports 12, no. 4 (2015): 5286-5292. https://doi.org/10.3892/mmr.2015.4088
Copy and paste a formatted citation
x
Spandidos Publications style
Xiong M, Liu L, Liu Z and Gao H: Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells. Mol Med Rep 12: 5286-5292, 2015.
APA
Xiong, M., Liu, L., Liu, Z., & Gao, H. (2015). Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells. Molecular Medicine Reports, 12, 5286-5292. https://doi.org/10.3892/mmr.2015.4088
MLA
Xiong, M., Liu, L., Liu, Z., Gao, H."Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells". Molecular Medicine Reports 12.4 (2015): 5286-5292.
Chicago
Xiong, M., Liu, L., Liu, Z., Gao, H."Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells". Molecular Medicine Reports 12, no. 4 (2015): 5286-5292. https://doi.org/10.3892/mmr.2015.4088
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