Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2015 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2015 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Functional and protein‑protein interaction network analysis of colorectal cancer induced by ulcerative colitis

  • Authors:
    • Yong Dai
    • Jin‑Bo Jiang
    • Yan‑Lei Wang
    • Zu‑Tao Jin
    • San‑Yuan Hu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Dai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4947-4958
    |
    Published online on: July 20, 2015
       https://doi.org/10.3892/mmr.2015.4102
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Colorectal cancer (CRC) is a well‑recognized complication of ulcerative colitis (UC), and patients with UC have a higher incidence of CRC, compared with the general population. However, the properties of CRC induced by UC have not been clarified using an interaction network to analyze and compare gene sets. In the present study, six microarray datasets of CRC and UC were extracted from the Array Express database, and gene signatures were identified using the genome‑wide relative significance (GWRS) method. Functional analysis was performed based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Prediction of the genes and microRNA were performed using a hypergeometric method. A protein‑protein interaction (PPI) network was constructed using the Search Tool for the Retrieval of Interacting Genes/proteins, and clusters were obtained through the Molecular Complex Detection algorithm. Topological centrality and a novel analyzing method, based on the rank value of GWGS, were used to characterize the biological importance of the clusters. A total of 217 differentially expressed (DE) genes of CRC were identified, 341 DE genes were identified in UC, and 62 common genes existed in the two. Several KEGG pathways were the same in CRC and UC. Collagenase, progesterone, heparin, urokinase, nadh and adenosine drugs demonstrated potential for use in treatment of CRC and UC. In the PPI network of CRC, 210 nodes and 752 edges were observed, wheras 314 nodes and 882 edges were identified in UC. Cluster 3 in UC had the highest GWGS, while the topological centrality of Cluster 3 in UC had the lowest degree and betweenness. PPI network analysis provided an effective way to estimate and understand the likelihood of the potential connections between proteins/genes. The results obtained following the use of GWGS to analyze differences between clusters did not agree with the topological degree and betweenness centrality, which indicated that gene fold change based GWGS was controversial with degree here in CRC and UC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Karlén P, Kornfeld D, Broström O, Löfberg R, Persson PG and Ekbom A: Is colonoscopic surveillance reducing colorectal cancer mortality in ulcerative colitis? A population based case control study. Gut. 42:711–714. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Kisiel JB, Garrity-Park MM, Taylor WR, Smyrk TC and Ahlquist DA: Methylated eyes absent 4 (EYA4) gene promotor in non-neoplastic mucosa of ulcerative colitis patients with colorectal cancer: Evidence for a field effect. Inflamm Bowel Dis. 19:2079–2083. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Watanabe T, Konishi T, Kishimoto J, Kotake K, Muto T and Sugihara K; Japanese Society for Cancer of the Colon and Rectum: Ulcerative colitis-associated colorectal cancer shows a poorer survival than sporadic colorectal cancer: A nationwide Japanese study. Inflamm Bowel Dis. 17:802–808. 2011. View Article : Google Scholar

4 

Bardelli A and Siena S: Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol. 28:1254–1261. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Saleh M and Trinchieri G: Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nat Rev Immunol. 11:9–20. 2011. View Article : Google Scholar

6 

Fearon ER: Molecular genetics of colorectal cancer. Ann Rev Pathol. 6:479–507. 2011. View Article : Google Scholar

7 

Suzuki H, Gabrielson E, Chen W, Anbazhagan R, van Engeland M, Weijenberg MP, Herman JG and Baylin SB: A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet. 31:141–149. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Cancer Genome Atlas Network: Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487:330–337. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Vinayagam A, Zirin J, Roesel C, Hu Y, Yilmazel B, Samsonova AA, Neumüller RA, Mohr SE and Perrimon N: Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Nat Methods. 11:94–99. 2014. View Article : Google Scholar

10 

Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, et al: A network-based analysis of systemic inflammation in humans. Nature. 437:1032–1037. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Goffard N and Weiller G: PathExpress: A web-based tool to identify relevant pathways in gene expression data. Nucleic Acids Res. 35:W176–W181. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Chuang HY, Lee E, Liu YT, Lee D and Ideker T: Network-based classification of breast cancer metastasis. Mol Syst Biol. 3:1402007. View Article : Google Scholar : PubMed/NCBI

13 

Nepusz T, Yu H and Paccanaro A: Detecting overlapping protein complexes in protein-protein interaction networks. Nat Methods. 9:471–472. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Winterhalter C, Widera P and Krasnogor N: JEPETTO: A cytoscape plugin for gene set enrichment and topological analysis based on interaction networks. Bioinformatics. 30:1029–1030. 2014. View Article : Google Scholar :

15 

Chuang HY, Hofree M and Ideker T: A decade of systems biology. Annu Rev Cell Dev Biol. 26:721–744. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Pržulj N, Wigle DA and Jurisica I: Functional topology in a network of protein interactions. Bioinformatics. 20:340–348. 2004. View Article : Google Scholar

17 

Wu F, Dassopoulos T, Cope L, Maitra A, Brant SR, Harris ML, Bayless TM, Parmigiani G and Chakravarti S: Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis. Inflamm Bowel Dis. 13:807–821. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Planell N, Lozano JJ, Mora-Buch R, Masamunt MC, Jimeno M, Ordás I, Esteller M, Ricart E, Piqué JM, Panés J, et al: Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations. Gut. 62:967–976. 2013. View Article : Google Scholar

19 

Sheffer M, Bacolod MD, Zuk O, Giardina SF, Pincas H, Barany F, Paty PB, Gerald WL, Notterman DA and Domany E: Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. Proc Natl Acad Sci USA. 106:7131–7136. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Galamb O, Spisák S, Sipos F, Tóth K, Solymosi N, Wichmann B, Krenács T, Valcz G, Tulassay Z and Molnár B: Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor. Br J Cancer. 102:765–773. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Ancona N, Maglietta R, Piepoli A, D'Addabbo A, Cotugno R, Savino M, Liuni S, Carella M, Pesole G and Perri F: On the statistical assessment of classifiers using DNA microarray data. BMC Bioinformatics. 7:3872006. View Article : Google Scholar : PubMed/NCBI

22 

Liu W, Peng Y and Tobin DJ: A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis. Peer J. 1:e492013. View Article : Google Scholar : PubMed/NCBI

23 

Smyth GK: Limma: Linear models for microarray data. Bioinformatics and computational biology solutions using R and Bioconductor. Statistics for Biology and Health. Gentleman, et al: Springer; New York, NY: pp. 397–420. 2005, View Article : Google Scholar

24 

Diboun I, Wernisch L, Orengo CA and Koltzenburg M: Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma. BMC Genomics. 7:2522006. View Article : Google Scholar : PubMed/NCBI

25 

Da Wei Huang BTS and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2008. View Article : Google Scholar

26 

Zhang B, Kirov S and Snoddy J: WebGestalt: An integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res. 33:W741–W748. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Wang J, Duncan D, Shi Z and Zhang B: WEB-based GEne SeT AnaLysis toolkit (WebGestalt): Update 2013. Nucleic Acids Res. 41:W77–W83. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Ferreira J and Zwinderman A: On the Benjamini-Hochberg method. Ann Statistics. 34:1827–1849. 2006. View Article : Google Scholar

29 

Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar :

30 

Wasserman S and Katherin Faust: Social Network Analysis: Methods and Applications. 1st edition. Cambridge University Press; Cambridge: 1994, View Article : Google Scholar

31 

Altman NS: Differential expression analysis using LIMMA. 2013

32 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar

33 

Gillen CD, Walmsley RS, Prior P, Andrews H and Allan RN: Ulcerative colitis and Crohn's disease: A comparison of the colorectal cancer risk in extensive colitis. Gut. 35:1590–1592. 1994. View Article : Google Scholar : PubMed/NCBI

34 

Loftus EV Jr, Harewood GC, Loftus CG, Tremaine WJ, Harmsen WS, Zinsmeister AR, Jewell DA and Sandborn WJ: PSC-IBD: A unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut. 54:91–96. 2005. View Article : Google Scholar

35 

Askling J, Dickman PW, Karlén P, Broström O, Lapidus A, Löfberg R and Ekbom A: Family history as a risk factor for colorectal cancer in inflammatory bowel disease. Gastroenterology. 120:1356–1362. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Wheeler JM, Kim HC, Efstathiou JA, Ilyas M, Mortensen NJ and Bodmer WF: Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer. Gut. 48:367–371. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Min M, Peng LH, Sun G, Guo MZ, Qiu ZW and Yang YS: Aquaporin 8 expression is reduced and regulated by microRNAs in patients with ulcerative colitis. Chin Med J. 126:1532–1537. 2013.PubMed/NCBI

38 

Watanabe T, Kobunai T, Yamamoto Y, Ikeuchi H, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Kanazawa T, Tanaka T, et al: Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis. Clin Colorectal Cancer. 10:134–141. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Rutter M, Saunders B, Wilkinson K, Rumbles S, Schofield G, Kamm M, Williams C, Price A, Talbot I and Forbes A: Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology. 126:451–459. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Rosenberg GA, Mun-Bryce S, Wesley M and Kornfeld M: Collagenase-induced intracerebral hemorrhage in rats. Stroke. 21:801–807. 1990. View Article : Google Scholar : PubMed/NCBI

41 

Ikeda S, Kong SW, Lu J, Bisping E, Zhang H, Allen PD, Golub TR, Pieske B and Pu WT: Altered microRNA expression in human heart disease. Physiol Genomics. 31:367–373. 2007. View Article : Google Scholar : PubMed/NCBI

42 

O'Connell RM, Rao DS and Baltimore D: microRNA regulation of inflammatory responses. Annu Rev Immunol. 30:295–312. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, et al: The colorectal microRNAome. Proc Natl Acad Sci USA. 103:3687–3692. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Wen Z, Liu ZP, Liu Z, Zhang Y and Chen L: An integrated approach to identify causal network modules of complex diseases with application to colorectal cancer. J Am Med Inform Assoc. 20:659–667. 2013. View Article : Google Scholar :

45 

Jonsson PF, Cavanna T, Zicha D and Bates PA: Cluster analysis of networks generated through homology: Automatic identification of important protein communities involved in cancer metastasis. BMC Bioinformatics. 7:22006. View Article : Google Scholar : PubMed/NCBI

46 

Srihari S and Ragan MA: Systematic tracking of dysregulated modules identifies novel genes in cancer. Bioinformatics. 29:1553–1561. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Estrada E: Virtual identification of essential proteins within the protein interaction network of yeast. Proteomics. 6:35–40. 2006. View Article : Google Scholar

48 

Ploug M, Gårdsvoll H, Jørgensen TJ, Lønborg Hansen L and Danø K: Structural analysis of the interaction between urokinase- type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy. Biochem Soc Trans. 30:177–183. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Finckh U, Van Hadeln K, Müller-Thomsen T, Alberici A, Binetti G, Hock C, Nitsch RM, Stoppe G, Reiss J and Gal A: Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22. 2. Neurogenetics. 4:213–217. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Opsahl T, Agneessens F and Skvoretz J: Node centrality in weighted networks: Generalizing degree and shortest paths. Soc Networks. 32:245–251. 2010. View Article : Google Scholar

51 

Ai J, Zhao H, Carley KM, Su Z and Li H: Neighbor vector centrality of complex networks based on neighbors degree distribution. Euro Phys J B. 86:1–7. 2013. View Article : Google Scholar

52 

Kapoor K, Sharma D and Srivastava J: Weighted node degree centrality for hypergraphs. Proceedings of the 2013 IEEE 2nd International Network Science Workshop; Westpoint, NY, USA. pp. 152–155. 2013

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Dai Y, Jiang JB, Wang YL, Jin ZT and Hu SY: Functional and protein‑protein interaction network analysis of colorectal cancer induced by ulcerative colitis. Mol Med Rep 12: 4947-4958, 2015.
APA
Dai, Y., Jiang, J., Wang, Y., Jin, Z., & Hu, S. (2015). Functional and protein‑protein interaction network analysis of colorectal cancer induced by ulcerative colitis. Molecular Medicine Reports, 12, 4947-4958. https://doi.org/10.3892/mmr.2015.4102
MLA
Dai, Y., Jiang, J., Wang, Y., Jin, Z., Hu, S."Functional and protein‑protein interaction network analysis of colorectal cancer induced by ulcerative colitis". Molecular Medicine Reports 12.4 (2015): 4947-4958.
Chicago
Dai, Y., Jiang, J., Wang, Y., Jin, Z., Hu, S."Functional and protein‑protein interaction network analysis of colorectal cancer induced by ulcerative colitis". Molecular Medicine Reports 12, no. 4 (2015): 4947-4958. https://doi.org/10.3892/mmr.2015.4102
Copy and paste a formatted citation
x
Spandidos Publications style
Dai Y, Jiang JB, Wang YL, Jin ZT and Hu SY: Functional and protein‑protein interaction network analysis of colorectal cancer induced by ulcerative colitis. Mol Med Rep 12: 4947-4958, 2015.
APA
Dai, Y., Jiang, J., Wang, Y., Jin, Z., & Hu, S. (2015). Functional and protein‑protein interaction network analysis of colorectal cancer induced by ulcerative colitis. Molecular Medicine Reports, 12, 4947-4958. https://doi.org/10.3892/mmr.2015.4102
MLA
Dai, Y., Jiang, J., Wang, Y., Jin, Z., Hu, S."Functional and protein‑protein interaction network analysis of colorectal cancer induced by ulcerative colitis". Molecular Medicine Reports 12.4 (2015): 4947-4958.
Chicago
Dai, Y., Jiang, J., Wang, Y., Jin, Z., Hu, S."Functional and protein‑protein interaction network analysis of colorectal cancer induced by ulcerative colitis". Molecular Medicine Reports 12, no. 4 (2015): 4947-4958. https://doi.org/10.3892/mmr.2015.4102
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team