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October-2015 Volume 12 Issue 4

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Article

Networks of micrornas and genes in acute lymphoblastic leukemia

  • Authors:
    • Yuhua Xie
    • Zhiwen Xu
    • Kunhao Wang
    • Ning Wang
    • Yunxiao Wang
    • Jiwei Bao
  • View Affiliations / Copyright

    Affiliations: Department of Computer Science and Technology, Jilin University, Changchun, Jilin 130012, P.R. China
  • Pages: 5361-5368
    |
    Published online on: July 23, 2015
       https://doi.org/10.3892/mmr.2015.4116
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Abstract

In the present study, three regulatory networks, including a network of differentially expressed factors, a related network and a global network, were constructed hierarchically in order to analyze the association between genes, micro (mi)RNAs and transcriptional factors (TFs) in a systematical approach, rather than focusing on only one or several miRNAs or TFs. By analyzing and comparing the similarities and differences among these three networks, a number of key pathways were highlighted. In addition, identifying the upstream and the downstream nodes, which were composed of differentially expressed genes and miRNAs in the networks provided assistance in identifying associations between circle‑regulations or self‑adaptation regulations among these elements. In the present study, the TP53 gene and the TP53 pathway were observed to be important in acute lymphoblastic leukemia (ALL). However, the predicted transcriptional factors, including EFKB1 and E2F1, which were found with self‑adaptaion associations and certain abnormally expressed miRNAs in the network of differentially expressed factors, requires further examination in further investigations of the pathogenesis of ALL. The confirmation of these factors may be of significance to ALL.
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Copy and paste a formatted citation
Spandidos Publications style
Xie Y, Xu Z, Wang K, Wang N, Wang Y and Bao J: Networks of micrornas and genes in acute lymphoblastic leukemia. Mol Med Rep 12: 5361-5368, 2015.
APA
Xie, Y., Xu, Z., Wang, K., Wang, N., Wang, Y., & Bao, J. (2015). Networks of micrornas and genes in acute lymphoblastic leukemia. Molecular Medicine Reports, 12, 5361-5368. https://doi.org/10.3892/mmr.2015.4116
MLA
Xie, Y., Xu, Z., Wang, K., Wang, N., Wang, Y., Bao, J."Networks of micrornas and genes in acute lymphoblastic leukemia". Molecular Medicine Reports 12.4 (2015): 5361-5368.
Chicago
Xie, Y., Xu, Z., Wang, K., Wang, N., Wang, Y., Bao, J."Networks of micrornas and genes in acute lymphoblastic leukemia". Molecular Medicine Reports 12, no. 4 (2015): 5361-5368. https://doi.org/10.3892/mmr.2015.4116
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Y, Xu Z, Wang K, Wang N, Wang Y and Bao J: Networks of micrornas and genes in acute lymphoblastic leukemia. Mol Med Rep 12: 5361-5368, 2015.
APA
Xie, Y., Xu, Z., Wang, K., Wang, N., Wang, Y., & Bao, J. (2015). Networks of micrornas and genes in acute lymphoblastic leukemia. Molecular Medicine Reports, 12, 5361-5368. https://doi.org/10.3892/mmr.2015.4116
MLA
Xie, Y., Xu, Z., Wang, K., Wang, N., Wang, Y., Bao, J."Networks of micrornas and genes in acute lymphoblastic leukemia". Molecular Medicine Reports 12.4 (2015): 5361-5368.
Chicago
Xie, Y., Xu, Z., Wang, K., Wang, N., Wang, Y., Bao, J."Networks of micrornas and genes in acute lymphoblastic leukemia". Molecular Medicine Reports 12, no. 4 (2015): 5361-5368. https://doi.org/10.3892/mmr.2015.4116
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