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Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension

  • Authors:
    • Baogang Wu
    • Ying Hao
    • Jin Shi
    • Ning Geng
    • Tiejun Li
    • Yanli Chen
    • Zhaoqing Sun
    • Liqiang Zheng
    • Hong Li
    • Naijing Li
    • Xingang Zhang
    • Yingxian Sun
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Geriatrics, Jinqiu Hospital, Shenyang, Liaoning 110016, P.R. China, Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5685-5690
    |
    Published online on: July 29, 2015
       https://doi.org/10.3892/mmr.2015.4135
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Abstract

The present study aimed to investigate the association between xanthine dehydrogenase (XDH) gene polymorphism and essential hypertension in the rural Han Chinese population of Fuxin, Liaoning. Han Chinese individuals, who had lived in rural areas of Fuxin, were selected as subjects for the present study. A total of 521 unrelated patients with hypertension were selected, along with a further 533 unrelated individuals with normal blood pressure, in order to serve as controls. Five tag single nucleotide polymorphisms (SNP) of the XDH gene were selected. An estimation of SNP allele frequency was determined using DNA pooling and pyrosequencing methods. Prior to Bonferroni correction, T allele frequency for rs206811 was significantly higher in patients with hypertension, as compared with the controls (64.1 vs. 59.4%; P=0.031); C allele frequency for rs1042039 was significantly higher in patients with hypertension, as compared with the controls (66.1 vs. 60.6%; P=0.011), C allele frequency for rs1054889 was significantly lower in patients with hypertension, as compared with the controls (38.8 vs. 44.8%; P=0.007); and A allele frequency for rs2073316 was significantly lower in patients with hypertension, as compared with the controls (29.2 vs. 34.4%; P=0.013). However, once a Bonferroni correction for multiple testing was applied, the XDH gene polymorphisms rs1042039, rs1054889, and rs2073316 were shown to be associated with hypertension (P=0.044, 0.035, and 0.039, respectively). These results suggest that the XDH gene polymorphisms rs1042039, rs1054889, and rs2073316 may be associated with hypertension in the rural Han Chinese population.
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Copy and paste a formatted citation
Spandidos Publications style
Wu B, Hao Y, Shi J, Geng N, Li T, Chen Y, Sun Z, Zheng L, Li H, Li N, Li N, et al: Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension. Mol Med Rep 12: 5685-5690, 2015.
APA
Wu, B., Hao, Y., Shi, J., Geng, N., Li, T., Chen, Y. ... Sun, Y. (2015). Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension. Molecular Medicine Reports, 12, 5685-5690. https://doi.org/10.3892/mmr.2015.4135
MLA
Wu, B., Hao, Y., Shi, J., Geng, N., Li, T., Chen, Y., Sun, Z., Zheng, L., Li, H., Li, N., Zhang, X., Sun, Y."Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension". Molecular Medicine Reports 12.4 (2015): 5685-5690.
Chicago
Wu, B., Hao, Y., Shi, J., Geng, N., Li, T., Chen, Y., Sun, Z., Zheng, L., Li, H., Li, N., Zhang, X., Sun, Y."Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension". Molecular Medicine Reports 12, no. 4 (2015): 5685-5690. https://doi.org/10.3892/mmr.2015.4135
Copy and paste a formatted citation
x
Spandidos Publications style
Wu B, Hao Y, Shi J, Geng N, Li T, Chen Y, Sun Z, Zheng L, Li H, Li N, Li N, et al: Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension. Mol Med Rep 12: 5685-5690, 2015.
APA
Wu, B., Hao, Y., Shi, J., Geng, N., Li, T., Chen, Y. ... Sun, Y. (2015). Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension. Molecular Medicine Reports, 12, 5685-5690. https://doi.org/10.3892/mmr.2015.4135
MLA
Wu, B., Hao, Y., Shi, J., Geng, N., Li, T., Chen, Y., Sun, Z., Zheng, L., Li, H., Li, N., Zhang, X., Sun, Y."Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension". Molecular Medicine Reports 12.4 (2015): 5685-5690.
Chicago
Wu, B., Hao, Y., Shi, J., Geng, N., Li, T., Chen, Y., Sun, Z., Zheng, L., Li, H., Li, N., Zhang, X., Sun, Y."Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension". Molecular Medicine Reports 12, no. 4 (2015): 5685-5690. https://doi.org/10.3892/mmr.2015.4135
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