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Article

Pravastatin inhibits fibrinogen‑ and FDP‑induced inflammatory response via reducing the production of IL‑6, TNF‑α and iNOS in vascular smooth muscle cells

  • Authors:
    • Peipei Lu
    • Juntian Liu
    • Xiaoming Pang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 6145-6151
    |
    Published online on: July 29, 2015
       https://doi.org/10.3892/mmr.2015.4149
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Abstract

Atherosclerosis is a chronic inflammatory response of the arterial wall to pro‑atherosclerotic factors. As an inflammatory marker, fibrinogen directly participates in the pathogenesis of atherosclerosis. Our previous study demonstrated that fibrinogen and fibrin degradation products (FDP) produce a pro‑inflammatory effect on vascular smooth muscle cells (VSMCs) through inducing the production of interleukin‑6 (IL‑6), tumor necrosis factor‑α (TNF‑α) and inducible nitric oxide synthase (iNOS). In the present study, the effects of pravastatin on fibrinogen‑ and FDP‑induced expression of IL‑6, TNF‑α and iNOS were observed in VSMCs. The results showed that pravastatin dose‑dependently inhibited fibrinogen‑ and FDP‑stimulated expression of IL‑6, TNF‑α and iNOS in VSMCs at the mRNA and protein level. The maximal inhibition of protein expression of IL‑6, TNF‑α and iNOS was 46.9, 42.7 and 49.2% in fibrinogen‑stimulated VSMCs, and 50.2, 49.8 and 53.6% in FDP‑stimulated VSMCs, respectively. This suggests that pravastatin has the ability to relieve vascular inflammation via inhibiting the generation of IL‑6, TNF‑α and iNOS. The results of the present study may aid in further explaining the beneficial effects of pravastatin on atherosclerosis and related cardiovascular diseases. In addition, they suggest that application of pravastatin may be beneficial for prevention of atherosclerosis formation in hyperfibrinogenemia.
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Copy and paste a formatted citation
Spandidos Publications style
Lu P, Liu J and Pang X: Pravastatin inhibits fibrinogen‑ and FDP‑induced inflammatory response via reducing the production of IL‑6, TNF‑α and iNOS in vascular smooth muscle cells. Mol Med Rep 12: 6145-6151, 2015.
APA
Lu, P., Liu, J., & Pang, X. (2015). Pravastatin inhibits fibrinogen‑ and FDP‑induced inflammatory response via reducing the production of IL‑6, TNF‑α and iNOS in vascular smooth muscle cells. Molecular Medicine Reports, 12, 6145-6151. https://doi.org/10.3892/mmr.2015.4149
MLA
Lu, P., Liu, J., Pang, X."Pravastatin inhibits fibrinogen‑ and FDP‑induced inflammatory response via reducing the production of IL‑6, TNF‑α and iNOS in vascular smooth muscle cells". Molecular Medicine Reports 12.4 (2015): 6145-6151.
Chicago
Lu, P., Liu, J., Pang, X."Pravastatin inhibits fibrinogen‑ and FDP‑induced inflammatory response via reducing the production of IL‑6, TNF‑α and iNOS in vascular smooth muscle cells". Molecular Medicine Reports 12, no. 4 (2015): 6145-6151. https://doi.org/10.3892/mmr.2015.4149
Copy and paste a formatted citation
x
Spandidos Publications style
Lu P, Liu J and Pang X: Pravastatin inhibits fibrinogen‑ and FDP‑induced inflammatory response via reducing the production of IL‑6, TNF‑α and iNOS in vascular smooth muscle cells. Mol Med Rep 12: 6145-6151, 2015.
APA
Lu, P., Liu, J., & Pang, X. (2015). Pravastatin inhibits fibrinogen‑ and FDP‑induced inflammatory response via reducing the production of IL‑6, TNF‑α and iNOS in vascular smooth muscle cells. Molecular Medicine Reports, 12, 6145-6151. https://doi.org/10.3892/mmr.2015.4149
MLA
Lu, P., Liu, J., Pang, X."Pravastatin inhibits fibrinogen‑ and FDP‑induced inflammatory response via reducing the production of IL‑6, TNF‑α and iNOS in vascular smooth muscle cells". Molecular Medicine Reports 12.4 (2015): 6145-6151.
Chicago
Lu, P., Liu, J., Pang, X."Pravastatin inhibits fibrinogen‑ and FDP‑induced inflammatory response via reducing the production of IL‑6, TNF‑α and iNOS in vascular smooth muscle cells". Molecular Medicine Reports 12, no. 4 (2015): 6145-6151. https://doi.org/10.3892/mmr.2015.4149
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