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Review

Long non-coding RNA HOTAIR: A novel oncogene (Review)

  • Authors:
    • Xin Yu
    • Zheng Li
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, P.R. China
  • Pages: 5611-5618
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    Published online on: July 31, 2015
       https://doi.org/10.3892/mmr.2015.4161
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Abstract

Long non-coding RNAs (lncRNAs) have been found to be pervasively transcribed in the genome and are critical regulators of the epigenome. Increasing evidence suggests that lncRNAs are aberrantly expressed in several types of human cancer and that they are important in the initiation, development and metastasis of human cancer. Previous studies have revealed that HOX transcript antisense intergenic RNA (HOTAIR) was frequently upregulated in various types of cancer, including breast cancer, esophageal cancer, lung cancer and gastric cancer. In addition, patients with high expression levels of HOTAIR have a significantly poorer prognosis, compared with those with low levels of expression. HOTAIR is involved in the control of cell apoptosis, growth, metastasis, angiogenesis, DNA repair and tumor cells metabolism. The present review provides an overview of the current knowledge concerning the role of HOTAIR in tumor development and progression.
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Spandidos Publications style
Yu X and Li Z: Long non-coding RNA HOTAIR: A novel oncogene (Review). Mol Med Rep 12: 5611-5618, 2015.
APA
Yu, X., & Li, Z. (2015). Long non-coding RNA HOTAIR: A novel oncogene (Review). Molecular Medicine Reports, 12, 5611-5618. https://doi.org/10.3892/mmr.2015.4161
MLA
Yu, X., Li, Z."Long non-coding RNA HOTAIR: A novel oncogene (Review)". Molecular Medicine Reports 12.4 (2015): 5611-5618.
Chicago
Yu, X., Li, Z."Long non-coding RNA HOTAIR: A novel oncogene (Review)". Molecular Medicine Reports 12, no. 4 (2015): 5611-5618. https://doi.org/10.3892/mmr.2015.4161
Copy and paste a formatted citation
x
Spandidos Publications style
Yu X and Li Z: Long non-coding RNA HOTAIR: A novel oncogene (Review). Mol Med Rep 12: 5611-5618, 2015.
APA
Yu, X., & Li, Z. (2015). Long non-coding RNA HOTAIR: A novel oncogene (Review). Molecular Medicine Reports, 12, 5611-5618. https://doi.org/10.3892/mmr.2015.4161
MLA
Yu, X., Li, Z."Long non-coding RNA HOTAIR: A novel oncogene (Review)". Molecular Medicine Reports 12.4 (2015): 5611-5618.
Chicago
Yu, X., Li, Z."Long non-coding RNA HOTAIR: A novel oncogene (Review)". Molecular Medicine Reports 12, no. 4 (2015): 5611-5618. https://doi.org/10.3892/mmr.2015.4161
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