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Article

Small interfering RNA-induced silencing of galectin-3 inhibits the malignant phenotypes of osteosarcoma in vitro

Retraction in: /10.3892/mmr.2021.12309
  • Authors:
    • Pengfei Lei
    • Hongbo He
    • Yihe Hu
    • Zhan Liao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 6316-6322
    |
    Published online on: July 31, 2015
       https://doi.org/10.3892/mmr.2015.4165
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Abstract

Osteosarcoma (OS) is the most common malignant tumor of bone. It has recently been demonstrated that galectin-3, a multifunctional β-galactoside-binding, is significantly upregulated in OS tissues, and is correlated with its progression and metastasis. However, the detailed role of galectin‑3 in the regulation of cellular biological processes in OS cells has remained to be elucidated. The present study reported that the mRNA and protein levels of galectin‑3 were significantly increased in OS tissues compared to those in their matched normal adjacent tissues. Furthermore, galectin‑3 was upregulated in three OS cell lines, Saos‑2, MG63 and U2OS, when compared with that in the human osteoblast cell line hFOB1.19. Knockdown of galectin‑3 by galectin‑3‑specific small interfering RNA markedly inhibited OS‑cell proliferation and induced cell apoptosis. Furthermore, silencing of galectin‑3 expression significantly inhibited OS cell migration and invasion, accompanied with a marked decrease in the protein expression of matrix metalloproteinase 2 and ‑9. Mechanistic investigation suggested that the mitogen‑activated protein kinase kinase/extracellular signal‑regulated protein kinase signaling pathway may be involved in the galectin‑3‑mediated OS cell invasion. In conclusion, the present study was the first to report that silencing of galectin‑3 inhibited the malignant phenotypes of osteosarcoma in vitro. Therefore, galectin-3 may serve as a potential therapeutic target for OS.
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Copy and paste a formatted citation
Spandidos Publications style
Lei P, He H, Hu Y and Liao Z: Small interfering RNA-induced silencing of galectin-3 inhibits the malignant phenotypes of osteosarcoma in vitro Retraction in /10.3892/mmr.2021.12309. Mol Med Rep 12: 6316-6322, 2015.
APA
Lei, P., He, H., Hu, Y., & Liao, Z. (2015). Small interfering RNA-induced silencing of galectin-3 inhibits the malignant phenotypes of osteosarcoma in vitro Retraction in /10.3892/mmr.2021.12309. Molecular Medicine Reports, 12, 6316-6322. https://doi.org/10.3892/mmr.2015.4165
MLA
Lei, P., He, H., Hu, Y., Liao, Z."Small interfering RNA-induced silencing of galectin-3 inhibits the malignant phenotypes of osteosarcoma in vitro Retraction in /10.3892/mmr.2021.12309". Molecular Medicine Reports 12.4 (2015): 6316-6322.
Chicago
Lei, P., He, H., Hu, Y., Liao, Z."Small interfering RNA-induced silencing of galectin-3 inhibits the malignant phenotypes of osteosarcoma in vitro Retraction in /10.3892/mmr.2021.12309". Molecular Medicine Reports 12, no. 4 (2015): 6316-6322. https://doi.org/10.3892/mmr.2015.4165
Copy and paste a formatted citation
x
Spandidos Publications style
Lei P, He H, Hu Y and Liao Z: Small interfering RNA-induced silencing of galectin-3 inhibits the malignant phenotypes of osteosarcoma in vitro Retraction in /10.3892/mmr.2021.12309. Mol Med Rep 12: 6316-6322, 2015.
APA
Lei, P., He, H., Hu, Y., & Liao, Z. (2015). Small interfering RNA-induced silencing of galectin-3 inhibits the malignant phenotypes of osteosarcoma in vitro Retraction in /10.3892/mmr.2021.12309. Molecular Medicine Reports, 12, 6316-6322. https://doi.org/10.3892/mmr.2015.4165
MLA
Lei, P., He, H., Hu, Y., Liao, Z."Small interfering RNA-induced silencing of galectin-3 inhibits the malignant phenotypes of osteosarcoma in vitro Retraction in /10.3892/mmr.2021.12309". Molecular Medicine Reports 12.4 (2015): 6316-6322.
Chicago
Lei, P., He, H., Hu, Y., Liao, Z."Small interfering RNA-induced silencing of galectin-3 inhibits the malignant phenotypes of osteosarcoma in vitro Retraction in /10.3892/mmr.2021.12309". Molecular Medicine Reports 12, no. 4 (2015): 6316-6322. https://doi.org/10.3892/mmr.2015.4165
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