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Article

High‑mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma

  • Authors:
    • Zhikui Liu
    • Changwei Dou
    • Yufeng Wang
    • Yuli Jia
    • Qing Li
    • Xin Zheng
    • Yingmin Yao
    • Qingguang Liu
    • Tao Song
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 5997-6004
    |
    Published online on: August 5, 2015
       https://doi.org/10.3892/mmr.2015.4182
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Abstract

High‑mobility group box 1 (HMGB1), a member of the high‑mobility group protein family, was originally characterized as a non‑histone, nuclear DNA‑binding protein. While the roles of HMGB1 in inflammation and cell differentiation have been previously reported, its role in tumor cell migration and invasion, particularly in hepatocellular carcinoma (HCC), has remained elusive. The present study reported that the expression of HMGB1 in HCC tissues was significantly higher than that in matched tumor‑adjacent tissues (P<0.05). HMGB1 was expressed at significantly elevated levels in tumors of patients with large tumor size, high histological grade and advanced tumor‑node‑metastasis stage (P<0.05). The positive expression of HMGB1 correlated with a poor three‑year overall and disease‑free survival of HCC patients (P<0.05). In addition, HMGB1 was an independent factor for predicting the three‑year overall and disease‑free survival of HCC patients (P<0.05). An in vitro experiment revealed that knockdown of HMGB1 inhibited cell migration and invasion in the HCC cell lines Huh7 and MHCC97H (P<0.05). Furthermore, western blot analysis showed that HMGB1 knockdown markedly inhibited epithelial mesenchymal transition in Huh7 and MHCC97H cells. These results suggested that HMGB1 may be utilized as an independent prognostic marker in HCC and may promote tumor progression by promoting cell migration and invasion.
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View References

1 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Smith MW, Yue ZN, Korth MJ, Do HA, Boix L, Fausto N, Bruix J, Carithers RL Jr and Katze MG: Hepatitis C virus and liver disease: Global transcriptional profling and identifcation of potential markers. Hepatology. 38:1458–1467. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Llovet JM, Di Bisceglie AM, Bruix J, Kramer BS, Lencioni R, Zhu AX, Sherman M, Schwartz M, Lotze M, Talwalkar J, et al: Design and endpoints of clinical trials in hepatocellular carcinoma. J Natl Cancer Inst. 100:698–711. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Talwalkar JA and Gores GJ: Diagnosis and staging of hepatocellular carcinoma. Gastroenterology. 127(5 Suppl 1): S126–S132. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Kim DH and Rossi JJ: Strategies for silencing human disease using RNA interference. Nat Rev Genet. 8:173–184. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Gartel AL and Kandel ES: RNA interference in cancer. Biomol Eng. 23:17–34. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Castanotto D and Rossi JJ: The promises and pitfalls of RNA-interference-based therapeutics. Nature. 457:426–433. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Javaherian K, Liu JF and Wang JC: Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. Science. 199:1345–1346. 1978. View Article : Google Scholar : PubMed/NCBI

9 

Lotze MT and Tracey KJ: High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal. Nat Rev Immunol. 5:331–42. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Sims GP, Rowe DC, Rietdijk ST, Herbst R and Coyle AJ: HMGB1 and RAGE in infammation and cancer. Annu Rev Immunol. 28:367–88. 2010. View Article : Google Scholar

11 

Tang D, Kang R, Zeh HJ III and Lotze MT: High-mobility group box 1 and cancer. Biochim Biophys Acta. 1799:131–40. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Kostova N, Zlateva S, Ugrinova I and Pasheva E: The expression of HMGB1 protein and its receptor RAGE in human malignant tumors. Mol Cell Biochem. 337:251–58. 2010. View Article : Google Scholar

13 

Park JS, Gamboni-Robertson F, He Q, Svetkauskaite D, Kim JY, Strassheim D, Sohn JW, Yamada S, Maruyama I, Banerjee A, et al: High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol. 290:C917–924. 2006. View Article : Google Scholar

14 

Yu M, Wang H, Ding A, Golenbock DT, Latz E, Czura CJ, Fenton MJ, Tracey KJ and Yang H: HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock. 26:174–79. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Wolfson RK, Chiang ET and Garcia JG: HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption. Microvasc Res. 81:189–97. 2011. View Article : Google Scholar

16 

Larocca C, Cohen JR, Fernando RI, Huang B, Hamilton DH and Palena C: An autocrine loop between TGF-β1 and the transcription factor brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype. Mol Cancer Ther. 12:1805–815. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Yang JD, Harmsen WS, Slettedahl SW, Chaiteerakij R, Enders FT, Therneau TM, Orsini L, Kim WR and Roberts LR: Factors that affect risk for hepatocellular carcinoma and effects of surveillance. Clin Gastroenterol Hepatol. 9:617–623.e1. 2011. View Article : Google Scholar : PubMed/NCBI

18 

El-Nahas AM: Plasticity of kidney cells: Role in kidney remodeling and scarring. Kidney Int. 64:1553–563. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Sato M, Shames DS and Hasegawa Y: Emerging evidence of epithelial-to-mesenchymal transition in lung carcinogenesis. Respirology. 17:1048–059. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Liu Z, Dou C, Jia Y, Li Q, Zheng X, Yai Y, Liu Q and Song T: RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9. Int J Oncol. 46:1710–720. 2015.PubMed/NCBI

21 

Rudmik LR and Magliocco AM: Molecular mechanisms of hepatic metastasis in colorectal cancer. J Surg Oncol. 92:347–59. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Kumar S and Weaver VM: Mechanics, malignancy and metastasis: The force journey of a tumor cell. Cancer Metastasis Rev. 28:113–27. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Naghavi MH, Nowak P, Andersson J, Sönnerborg A, Yang H, Tracey KJ and Vahlne A: Intracellular high mobility group B1 protein (HMGB1) represses HIV-1 LTR-directed transcription in a promoter-and cell-specifc manner. Virology. 314:179–189. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Ueda M, Takahashi Y, Shinden Y, Sakimura S, Hirata H, Uchi R, Takano Y, Kurashige J, Iguchi T, Eguchi H, et al: Prognostic signifcance of high mobility group box 1 (HMGB1) expression in patients with colorectal cancer. Anticancer Res. 34:5357–5362. 2014.PubMed/NCBI

25 

Li LC, Gao J and Li J: Emerging role of HMGB1 in fbrotic diseases. J Cell Mol Med. 18:2331–2339. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Dou C, Wang Y, Jia Y, Li Q, Zheng X, Yao Y, Liu Q and Song T: High‑mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma. Mol Med Rep 12: 5997-6004, 2015.
APA
Liu, Z., Dou, C., Wang, Y., Jia, Y., Li, Q., Zheng, X. ... Song, T. (2015). High‑mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma. Molecular Medicine Reports, 12, 5997-6004. https://doi.org/10.3892/mmr.2015.4182
MLA
Liu, Z., Dou, C., Wang, Y., Jia, Y., Li, Q., Zheng, X., Yao, Y., Liu, Q., Song, T."High‑mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma". Molecular Medicine Reports 12.4 (2015): 5997-6004.
Chicago
Liu, Z., Dou, C., Wang, Y., Jia, Y., Li, Q., Zheng, X., Yao, Y., Liu, Q., Song, T."High‑mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma". Molecular Medicine Reports 12, no. 4 (2015): 5997-6004. https://doi.org/10.3892/mmr.2015.4182
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Dou C, Wang Y, Jia Y, Li Q, Zheng X, Yao Y, Liu Q and Song T: High‑mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma. Mol Med Rep 12: 5997-6004, 2015.
APA
Liu, Z., Dou, C., Wang, Y., Jia, Y., Li, Q., Zheng, X. ... Song, T. (2015). High‑mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma. Molecular Medicine Reports, 12, 5997-6004. https://doi.org/10.3892/mmr.2015.4182
MLA
Liu, Z., Dou, C., Wang, Y., Jia, Y., Li, Q., Zheng, X., Yao, Y., Liu, Q., Song, T."High‑mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma". Molecular Medicine Reports 12.4 (2015): 5997-6004.
Chicago
Liu, Z., Dou, C., Wang, Y., Jia, Y., Li, Q., Zheng, X., Yao, Y., Liu, Q., Song, T."High‑mobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma". Molecular Medicine Reports 12, no. 4 (2015): 5997-6004. https://doi.org/10.3892/mmr.2015.4182
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