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Article Open Access

Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation

Corrigendum in: /mmr/12/6/8327
  • Authors:
    • Guo-Ying Su
    • Jing Wang
    • Zhen-Xing Xu
    • Xiao-Jun Qiao
    • Jing-Quan Zhong
    • Yun Zhang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Cardiology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5746-5752
    |
    Published online on: August 6, 2015
       https://doi.org/10.3892/mmr.2015.4193
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Abstract

The present study investigated the effects of rotigaptide (ZP123) on the expression, distribution and phosphorylation of connexin43 (Cx43) in myocardial cell membranes in cardioversion of ventricular fibrillation (VF). A model of prolonged VF (8, 12 and 30 min) was established in mongrel dogs (n=8/group), following treatment with ZP123 or normal saline (NS control). A sham control was included. Cardiopulmonary resuscitation was begun at the start of VF followed by defibrillation. Animals received a maximum of three defibrillations of increasing energy (70, 100 and 150 J biphasic shock) as required. The average defibrillation energy, defibrillation success rate, return of spontaneous circulation and survival rate were recorded. Cx43 and phosphorylated (p-)Cx43 expression in cardiomyocyte membranes was detected by western blot and immunofluorescence analyses. Compared with the NS-treated control groups, the success defibrillation rate in the 8-min and 12-min ZP123 groups was significantly higher (P<0.05), while the average defibrillation energy was significantly lower (P<0.05). Cx43 expression in the VF groups was significantly lower than that in the sham control group (P<0.05). Cx43 expression was higher in the 12-min and 30-min ZP123 groups than that in the NS control group (P<0.05), while p-Cx43 expression decreased, although the levels were significantly higher than those in the control groups (P<0.05). Cx43 expression was positively correlated with the defibrillation success rate (r=0.91; P<0.01) and negatively with the mean defibrillation energy (r=-0.854; P<0.01), while p-Cx43 expression was positively correlated with the success rate of the previous three defibrillations (r=0.926; P<0.01).In conclusion, ZP123 reduced Cx43 remodeling through regulating the expression, distribution and phosphorylation of Cx43, thereby reducing the defibrillation energy required for successful cardioversion.
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Copy and paste a formatted citation
Spandidos Publications style
Su G, Wang J, Xu Z, Qiao X, Zhong J and Zhang Y: Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation Corrigendum in /mmr/12/6/8327. Mol Med Rep 12: 5746-5752, 2015.
APA
Su, G., Wang, J., Xu, Z., Qiao, X., Zhong, J., & Zhang, Y. (2015). Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation Corrigendum in /mmr/12/6/8327. Molecular Medicine Reports, 12, 5746-5752. https://doi.org/10.3892/mmr.2015.4193
MLA
Su, G., Wang, J., Xu, Z., Qiao, X., Zhong, J., Zhang, Y."Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation Corrigendum in /mmr/12/6/8327". Molecular Medicine Reports 12.4 (2015): 5746-5752.
Chicago
Su, G., Wang, J., Xu, Z., Qiao, X., Zhong, J., Zhang, Y."Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation Corrigendum in /mmr/12/6/8327". Molecular Medicine Reports 12, no. 4 (2015): 5746-5752. https://doi.org/10.3892/mmr.2015.4193
Copy and paste a formatted citation
x
Spandidos Publications style
Su G, Wang J, Xu Z, Qiao X, Zhong J and Zhang Y: Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation Corrigendum in /mmr/12/6/8327. Mol Med Rep 12: 5746-5752, 2015.
APA
Su, G., Wang, J., Xu, Z., Qiao, X., Zhong, J., & Zhang, Y. (2015). Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation Corrigendum in /mmr/12/6/8327. Molecular Medicine Reports, 12, 5746-5752. https://doi.org/10.3892/mmr.2015.4193
MLA
Su, G., Wang, J., Xu, Z., Qiao, X., Zhong, J., Zhang, Y."Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation Corrigendum in /mmr/12/6/8327". Molecular Medicine Reports 12.4 (2015): 5746-5752.
Chicago
Su, G., Wang, J., Xu, Z., Qiao, X., Zhong, J., Zhang, Y."Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation Corrigendum in /mmr/12/6/8327". Molecular Medicine Reports 12, no. 4 (2015): 5746-5752. https://doi.org/10.3892/mmr.2015.4193
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