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IDH1R132H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a

  • Authors:
    • Quan‑Min Nie
    • Ying‑Ying Lin
    • Xi Yang
    • Lin Shen
    • Lie‑Mei Guo
    • Shuang‑Lin Que
    • Xiao‑Xiong Li
    • Jian‑Wei Ge
    • Gui‑Song Wang
    • Wen‑Hao Xiong
    • Pin Guo
    • Yong‑Ming Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China, Shanghai Institute of Head Trauma, Shanghai 200127, P.R. China, Department of Neurosurgery, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, Fujian 364000, P.R. China, Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China
    Copyright: © Nie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6695-6701
    |
    Published online on: August 24, 2015
       https://doi.org/10.3892/mmr.2015.4241
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Abstract

Mutations in isocitrate dehydrogenase 1 (IDH1) are found in >70% of secondary glioblastomas and lower-grade gliomas (grades II-III). Among the numerous phenotypic differences between IDH1 mutant and wild-type glioma patients, the most salient is an improved survival rate for patients with a mutation. MicroRNAs (miRNAs) are a class of small, non‑coding, single‑stranded RNAs that can negatively regulate gene expression at the post‑transcriptional level, predominantly by binding to the 3'‑untranslated region of their target mRNAs. The dysregulated expression of several miRNAs has been reported to modulate glioma progression; however, it is unclear whether mutations in IDH1 regulate glioma cell proliferation through miRNA dysregulation. In the present study, stable overexpression of IDH1WT or IDH1R132H was established in the U87 glioma cell line. It was found that IDH1R132H decreased cell proliferation of U87 glioma cells by inducing the expression of the miRNA miR‑128a. This process was dependent on the transcription factor hypoxia inducible factor‑1α (HIF‑1α), which binds to a hypoxia response element in the promoter of miR‑128a. Furthermore, miR‑128a negatively regulated the expression of B‑cell‑specific Moloney murine leukemia virus integration site 1 protein (Bmi‑1), which is involved in suppressing cell proliferation. These findings suggest that the IDH1R132H‑HIF‑1α‑miR‑128a‑Bmi‑1 pathway is involved in glioma cell proliferation.
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1 

Johannessen TC, Prestegarden L, Grudic A, Hegi ME, Tysnes BB and Bjerkvig R: The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells. Neuro Oncol. 15:269–278. 2013. View Article : Google Scholar :

2 

Hill VK, Shinawi T, Ricketts CJ, Krex D, Schackert G, Bauer J, Wei W, Cruickshank G, Maher ER and Latif F: Stability of the CpG island methylator phenotype during glioma progression and identification of methylated loci in secondary glioblastomas. BMC Cancer. 14:5062014. View Article : Google Scholar : PubMed/NCBI

3 

Agarwal S, Sharma MC and Jha P, Pathak P, Suri V, Sarkar C, Chosdol K, Suri A, Kale SS, Mahapatra AK and Jha P: Comparative study of IDH1 mutations in gliomas by immunohistochemistry and DNA sequencing. Neuro Oncol. 15:718–726. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, et al: IDH1 and IDH2 mutations in gliomas. N Engl J Med. 360:765–773. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Henriksen M, Johnsen KB, Andersen HH, Pilgaard L and Duroux M: MicroRNA expression signatures determine prognosis and survival in glioblastoma multiforme - a systematic overview. Mol Neurobiol. 50:896–913. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Blenkiron C and Miska EA: MiRNAs in cancer: Approaches, aetiology, diagnostics and therapy. Hum Mol Genet. 16(Spec No 1): R106–R113. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Zhang W, Zhang J, Yan W, You G, Bao Z, Li S, Kang C, Jiang C, You Y, Zhang Y, et al: Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme. Cancer. 119:814–824. 2013. View Article : Google Scholar

8 

Srinivasan S, Patric IR and Somasundaram K: A ten-microRNA expression signature predicts survival in glioblastoma. PLoS One. 6:e174382011. View Article : Google Scholar : PubMed/NCBI

9 

Novakova J, Slaby O, Vyzula R and Michalek J: MicroRNA involvement in glioblastoma pathogenesis. Biochem Biophys Res Commun. 386:1–5. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E and Ambros V: Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 5:R132004. View Article : Google Scholar : PubMed/NCBI

11 

Wang Z, Bao Z, Yan W, You G, Wang Y, Li X and Zhang W: Isocitrate dehydrogenase 1 (IDH1) mutation-specific microRNA signature predicts favorable prognosis in glioblastoma patients with IDH1 wild type. J Exp Clin Cancer Res. 32:592013. View Article : Google Scholar : PubMed/NCBI

12 

Ma X, Yoshimoto K, Guan Y, Hata N, Mizoguchi M, Sagata N, Murata H, Kuga D, Amano T, Nakamizo A and Sasaki T: Associations between microRNA expression and mesenchymal marker gene expression in glioblastoma. Neuro Oncol. 14:1153–1162. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Papagiannakopoulos T, Friedmann-Morvinski D, Neveu P, Dugas JC, Gill RM, Huillard E, Liu C, Zong H, Rowitch DH and Barres BA: Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene. 31:1884–1895. 2012. View Article : Google Scholar

14 

Cui JG, Zhao Y, Sethi P, Li YY, Mahta A, Culicchia F and Lukiw WJ: Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation. J Neurooncol. 98:297–304. 2010. View Article : Google Scholar

15 

Sanson M, Marie Y, Paris S, Idbaih A, Laffaire J, Ducray F, El Hallani S, Boisselier B, Mokhtari K, Hoang-Xuan K and Delattre JY: Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J Clin Oncol. 27:4150–4154. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, et al: Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 324:261–265. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Hu YL, DeLay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS and Aghi MK: Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res. 72:1773–1783. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Lakomy R, Sana J, Hankeova S, Fadrus P, Kren L, Lzicarova E, Svoboda M, Dolezelova H, Smrcka M, Vyzula R, et al: MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients. Cancer Sci. 102:2186–2190. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Godlewski J, Nowicki MO, Bronisz A, Williams S, Otsuki A, Nuovo G, Raychaudhury A, Newton HB, Chiocca EA and Lawler S: Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 68:9125–9130. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Bralten LB, Kloosterhof NK, Balvers R, Sacchetti A, Lapre L, Lamfers M, Leenstra S, de Jonge H, Kros JM, Jansen EE, et al: IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo. Ann Neurol. 69:455–463. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Zhu J, Zuo J, Xu Q, Wang X, Wang Z and Zhou D: Isocitrate dehydrogenase mutations may be a protective mechanism in glioma patients. Med Hypotheses. 76:602–603. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Ciafrè SA, Galardi S, Mangiola A, Ferracin M, Liu CG, Sabatino G, Negrini M, Maira G, Croce CM and Farace MG: Extensive modulation of a set of microRNAs in primary glio-blastoma. Biochem Biophys Res Commun. 334:1351–1358. 2005. View Article : Google Scholar

23 

Peruzzi P, Bronisz A, Nowicki MO, Wang Y, Ogawa D, Price R, Nakano I, Kwon CH, Hayes J, Lawler SE, et al: MicroRNA-128 coordinately targets polycomb repressor complexes in glioma stem cells. Neuro Oncol. 15:1212–1224. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Shi ZM, Wang J, Yan Z, You YP, Li CY, Qian X, Yin Y, Zhao P, Wang YY, Wang XF, et al: MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1. PLoS One. 7:e327092012. View Article : Google Scholar : PubMed/NCBI

25 

Venkataraman S, Alimova I, Fan R, Harris P, Foreman N and Vibhakar R: MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence. PLoS One. 5:e107482010. View Article : Google Scholar : PubMed/NCBI

26 

Kamiyama H, Takano S, Tsuboi K and Matsumura A: Anti-angiogenic effects of SN38 (active metabolite of irinotecan): Inhibition of hypoxia-inducible factor 1 alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) expression of glioma and growth of endothelial cells. J Cancer Res Clin Oncol. 131:205–213. 2005. View Article : Google Scholar

27 

Ichimura K: Molecular pathogenesis of IDH mutations in gliomas. Brain Tumor Pathol. 29:131–139. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Nanta R, Kumar D, Meeker D, et al: NVP-LDE-225 (Erismodegib) inhibits epithelial-mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128. Oncogenesis. 2:e422013. View Article : Google Scholar

29 

Li J, Gong LY, Song LB, Jiang LL, Liu LP, Wu J, Yuan J, Cai JC, He M, Wang L, et al: Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway. Am J Pathol. 176:699–709. 2010. View Article : Google Scholar :

30 

Farivar S, Zati Keikha R, Shiari R and Jadali F: Expression of bmi-1 in pediatric brain tumors as a new independent prognostic marker of patient survival. Biomed Res Int. 2013:1925482013. View Article : Google Scholar : PubMed/NCBI

31 

Siddique HR, Parray A, Zhong W, Karnes RJ, Bergstralh EJ, Koochekpour S, Rhim JS, Konety BR and Saleem M: BMI1, stem cell factor acting as novel serum-biomarker for Caucasian and African-American prostate cancer. PLoS One. 8:e529932013. View Article : Google Scholar : PubMed/NCBI

32 

Bruggeman SW, Hulsman D, Tanger E, Buckle T, Blom M, Zevenhoven J, van Tellingen O and van Lohuizen M: Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma. Cancer Cell. 12:328–341. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nie QM, Lin YY, Yang X, Shen L, Guo LM, Que SL, Li XX, Ge JW, Wang GS, Xiong WH, Xiong WH, et al: IDH1R132H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a. Mol Med Rep 12: 6695-6701, 2015.
APA
Nie, Q., Lin, Y., Yang, X., Shen, L., Guo, L., Que, S. ... Qiu, Y. (2015). IDH1R132H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a. Molecular Medicine Reports, 12, 6695-6701. https://doi.org/10.3892/mmr.2015.4241
MLA
Nie, Q., Lin, Y., Yang, X., Shen, L., Guo, L., Que, S., Li, X., Ge, J., Wang, G., Xiong, W., Guo, P., Qiu, Y."IDH1R132H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a". Molecular Medicine Reports 12.5 (2015): 6695-6701.
Chicago
Nie, Q., Lin, Y., Yang, X., Shen, L., Guo, L., Que, S., Li, X., Ge, J., Wang, G., Xiong, W., Guo, P., Qiu, Y."IDH1R132H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a". Molecular Medicine Reports 12, no. 5 (2015): 6695-6701. https://doi.org/10.3892/mmr.2015.4241
Copy and paste a formatted citation
x
Spandidos Publications style
Nie QM, Lin YY, Yang X, Shen L, Guo LM, Que SL, Li XX, Ge JW, Wang GS, Xiong WH, Xiong WH, et al: IDH1R132H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a. Mol Med Rep 12: 6695-6701, 2015.
APA
Nie, Q., Lin, Y., Yang, X., Shen, L., Guo, L., Que, S. ... Qiu, Y. (2015). IDH1R132H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a. Molecular Medicine Reports, 12, 6695-6701. https://doi.org/10.3892/mmr.2015.4241
MLA
Nie, Q., Lin, Y., Yang, X., Shen, L., Guo, L., Que, S., Li, X., Ge, J., Wang, G., Xiong, W., Guo, P., Qiu, Y."IDH1R132H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a". Molecular Medicine Reports 12.5 (2015): 6695-6701.
Chicago
Nie, Q., Lin, Y., Yang, X., Shen, L., Guo, L., Que, S., Li, X., Ge, J., Wang, G., Xiong, W., Guo, P., Qiu, Y."IDH1R132H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a". Molecular Medicine Reports 12, no. 5 (2015): 6695-6701. https://doi.org/10.3892/mmr.2015.4241
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