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Article

Upregulation of microRNA-204 inhibits cell proliferation, migration and invasion in human renal cell carcinoma cells by downregulating SOX4

  • Authors:
    • Deyao Wu
    • Huixing Pan
    • Yunfeng Zhou
    • Zichun Zhang
    • Ping Qu
    • Jian Zhou
    • Wanxiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng City No. 1 People's Hospital, Yancheng, Jiangsu 224001, P.R. China, Inspection Branch, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng City No. 1 People's Hospital, Yancheng, Jiangsu 224001, P.R. China
  • Pages: 7059-7064
    |
    Published online on: August 27, 2015
       https://doi.org/10.3892/mmr.2015.4259
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Abstract

MicroRNA-204 (miR-204) has been reported to be frequently downregulated in various types of cancer, including renal, brain, ovary, hematological and colon cancer. The present study, investigated the effects of miR‑204 on renal cell carcinoma. Following transfection of miR‑204, an MTT assay, cell migration assay, cell invasion assay, western blot analysis and luciferase assay were performed in renal cell carcinoma cell lines. It was demonstrated that miR‑204 inhibits cell proliferation, migration and invasion in 786‑O and A498 cells. To the best of our knowledge, this study is the first to demonstrate that miR‑204 directly targets SOX4 in renal cell carcinoma. These results suggested that miR-204 may have value as a marker for the early detection of tumor metastasis and a therapeutic target preventing the invasion of renal cell carcinoma.
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1 

Lian JH, Wang WH, Wang JQ, Zhang YH and Li Y: MicroRNA-122 promotes proliferation, invasion and migration of renal cell carcinoma cells through the PI3K/Akt signaling pathway. Asian Pac J Cancer Prev. 14:5017–5021. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Motzer RJ, Bander NH and Nanus DM: Renal-cell carcinoma. N Engl J Med. 335:865–875. 1996. View Article : Google Scholar : PubMed/NCBI

3 

Toma MI, Erdmann K, Diezel M, Meinhardt M, Zastrow S, Fuessel S, Wirth MP and Baretton GB: Lack of ephrin receptor A1 is a favorable independent prognostic factor in clear cell renal cell carcinoma. PloS One. 9:e1022622014. View Article : Google Scholar : PubMed/NCBI

4 

Yang YQ and Chen J: Predictive role of vascular endothelial growth factor polymorphisms in the survival of renal cell carcinoma patients. Genet Mol Res. 13:5011–5017. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Kardas I, Mrózek K, Babinska M, Krajka K, Hadaczek P, Lubinski J, Roszkiewicz A, Kuziemska E and Limon J: Cytogenetic and molecular findings in 75 clear cell renal cell carcinomas. Oncol Rep. 13:949–956. 2005.PubMed/NCBI

6 

Girolami F, Passerini I, Gargano D, Frusconi S, Villari D, Nicita G and Torricelli F: Microsatellite analysis of chromosome 3p region in sporadic renal cell carcinomas. Pathol Oncol Res. 8:241–244. 2002. View Article : Google Scholar

7 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Wu D, Tao J, Xu B, Li P, Lu Q and Zhang W: Downregulation of Dicer, a component of the microRNA machinery, in bladder cancer. Mol Med Rep. 5:695–699. 2012.

9 

Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, Sohn SY, Cho Y, Zhang BT and Kim VN: Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell. 125:887–901. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Rådmark O, Kim S and Kim VN: The nuclear RNase III Drosha initiates microRNA processing. Nature. 425:415–419. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Lee Y, Han J, Yeom KH, Jin H and Kim VN: Drosha in primary microRNA processing. Cold Spring Harb Symp Quant Biol. 71:51–57. 2006. View Article : Google Scholar

12 

Yeom KH, Lee Y, Han J, Suh MR and Kim VN: Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing. Nucleic Acids Res. 34:4622–4629. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Bohnsack MT, Czaplinski K and Gorlich D: Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA. 10:185–191. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K and Shiekhattar R: TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 436:740–744. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Lund E, Guttinger S, Calado A, Dahlberg JE and Kutay U: Nuclear export of microRNA precursors. Science. 303:95–98. 2004. View Article : Google Scholar

16 

Berdnik D, Fan AP, Potter CJ and Luo L: MicroRNA processing pathway regulates olfactory neuron morphogenesis. Curr Biol. 18:1754–1759. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Fu W, Pang L, Chen Y, Yang L, Zhu J and Wei Y: The microRNAs as prognostic biomarkers for survival in esophageal cancer: A meta-analysis. Scientific World Journal. 2014:5239792014. View Article : Google Scholar : PubMed/NCBI

18 

Yuan W, Sui C, Liu Q, Tang W, An H and Ma J: Up-regulation of microRNA-145 associates with lymph node metastasis in colorectal cancer. PloS One. 9:e1020172014. View Article : Google Scholar : PubMed/NCBI

19 

Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Zhou X, Li L, Su J and Zhang G: Decreased miR-204 in H. pylori-associated gastric cancer promotes cancer cell proliferation and invasion by targeting SOX4. PloS One. 9:e1014572014. View Article : Google Scholar : PubMed/NCBI

22 

Kozomara A and Griffiths-Jones S: miRBase: Integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res. 39:D152–D157. 2011. View Article : Google Scholar :

23 

Griffiths-Jones S, Saini HK, van Dongen S and Enright AJ: miRBase: Tools for microRNA genomics. Nucleic Acids Res. 36:D154–D158. 2008. View Article : Google Scholar :

24 

Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright AJ: miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 34:D140–D144. 2006. View Article : Google Scholar :

25 

Zhou Y, Wu D, Tao J, Qu P, Zhou Z and Hou J: MicroRNA-133 inhibits cell proliferation, migration and invasion by targeting epidermal growth factor receptor and its downstream effector proteins in bladder cancer. Scand J Urol. 47:423–432. 2013. View Article : Google Scholar

26 

Xue YJ, Xiao RH, Long DZ, Zou XF, Wang XN, Zhang GX, Yuan YH, Wu GQ, Yang J, Wu YT, et al: Overexpression of FoxM1 is associated with tumor progression in patients with clear cell renal cell carcinoma. J Transl Med. 10:2002012. View Article : Google Scholar : PubMed/NCBI

27 

Bauer VL, Braselmann H, Henke M, Mattern D, Walch A, Unger K, Baudis M, Lassmann S, Huber R, Wienberg J, et al: Chromosomal changes characterize head and neck cancer with poor prognosis. J Mol Med (Berl). 86:1353–1365. 2008. View Article : Google Scholar

28 

Abou-Elhamd KE, Habib TN, Moussa AE and Badawy BS: The role of genetic susceptibility in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol. 265:217–222. 2008. View Article : Google Scholar

29 

Scully C, Field JK and Tanzawa H: Genetic aberrations in oral or head and neck squamous cell carcinoma 2: Chromosomal aberrations. Oral Oncol. 36:311–327. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A and Tuschl T: New microRNAs from mouse and human. RNA. 9:175–179. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Wang FE, Zhang C, Maminishkis A, Dong L, Zhi C, Li R, Zhao J, Majerciak V, Gaur AB, Chen S and Miller SS: MicroRNA-204/211 alters epithelial physiology. FASEB J. 24:1552–1571. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Gong M, Ma J, Li M, Zhou M, Hock JM and Yu X: MicroRNA-204 critically regulates carcinogenesis in malignant peripheral nerve sheath tumors. Neuro Oncol. 14:1007–1017. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Garzon R, Garofalo M, Martelli MP, Briesewitz R, Wang L, Fernandez-Cymering C, Volinia S, Liu CG, Schnittger S, Haferlach T, et al: Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci USA. 105:3945–3950. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Mikhaylova O, Stratton Y, Hall D, Kellner E, Ehmer B, Drew AF, Gallo CA, Plas DR, Biesiada J, Meller J and Czyzyk-Krzeska MF: VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. Cancer cell. 21:532–546. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Huang J, Zhao L, Xing L and Chen D: MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem cells. 28:357–364. 2010.

36 

Courboulin A, Paulin R, Giguère NJ, Saksouk N, Perreault T, Meloche J, Paquet ER, Biardel S, Provencher S, Côté J, et al: Role for miR-204 in human pulmonary arterial hypertension. J Exp Med. 208:535–548. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Conte I, Carrella S, Avellino R, Karali M, Marco-Ferreres R, Bovolenta P and Banfi S: miR-204 is required for lens and retinal development via Meis2 targeting. Proc Natl Acad Sci USA. 107:15491–15496. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Natera-Naranjo O, Aschrafi A, Gioio AE and Kaplan BB: Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons. RNA. 16:1516–1529. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Lee Y, Yang X, Huang Y, Fan H, Zhang Q, Wu Y, Li J, Hasina R, Cheng C, Lingen MW, et al: Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis. PLoS Comput Biol. 6:e10007302010. View Article : Google Scholar : PubMed/NCBI

40 

Chung TK, Lau TS, Cheung TH, Yim SF, Lo KW, Siu NS, Chan LK, Yu MY, Kwong J, Doran G, et al: Dysregulation of microRNA-204 mediates migration and invasion of endometrial cancer by regulating FOXC1. Int J Cancer. 130:1036–1045. 2012. View Article : Google Scholar

41 

Ryan J, Tivnan A, Fay J, Bryan K, Meehan M, Creevey L, Lynch J, Bray IM, O'Meara A, Tracey L, et al: MicroRNA-204 increases sensitivity of neuroblastoma cells to cisplatin and is associated with a favourable clinical outcome. Br J Cancer. 107:967–976. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Ying Z, Li Y, Wu J, Zhu X, Yang Y, Tian H, Li W, Hu B, Cheng SY and Li M: Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype. Cancer Res. 73:990–999. 2013. View Article : Google Scholar :

43 

Penzo-Mendez AI: Critical roles for SoxC transcription factors in development and cancer. Int J Biochem Cell Biol. 42:425–428. 2010. View Article : Google Scholar :

44 

Gunes S, Yegin Z, Sullu Y, Buyukalpelli R and Bagci H: SOX4 expression levels in urothelial bladder carcinoma. Pathol Res Pract. 207:423–427. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Hur W, Rhim H, Jung CK, Kim JD, Bae SH, Jang JW, Yang JM, Oh ST, Kim DG, Wang HJ, et al: SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: Clinical implication and functional analysis in vitro. Carcinogenesis. 31:1298–1307. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Aaboe M, Birkenkamp-Demtroder K, Wiuf C, Sørensen FB, Thykjaer T, Sauter G, Jensen KM, Dyrskjøt L and Ørntoft T: SOX4 expression in bladder carcinoma: Clinical aspects and in vitro functional characterization. Cancer Res. 66:3434–3442. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Jang SM, Kang EJ, Kim JW, Kim CH, An JH and Choi KH: Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA. Biochem Biophys Res Commun. 438:445–451. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Jafarnejad SM, Wani AA, Martinka M and Li G: Prognostic significance of Sox4 expression in human cutaneous melanoma and its role in cell migration and invasion. Am J Pathol. 177:2741–2752. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Liao YL, Sun YM, Chau GY, Chau YP, Lai TC, Wang JL, Horng JT, Hsiao M and Tsou AP: Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma. Oncogene. 27:5578–5589. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Pramoonjago P, Baras AS and Moskaluk CA: Knockdown of Sox4 expression by RNAi induces apoptosis in ACC3 cells. Oncogene. 25:5626–5639. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu D, Pan H, Zhou Y, Zhang Z, Qu P, Zhou J and Wang W: Upregulation of microRNA-204 inhibits cell proliferation, migration and invasion in human renal cell carcinoma cells by downregulating SOX4. Mol Med Rep 12: 7059-7064, 2015.
APA
Wu, D., Pan, H., Zhou, Y., Zhang, Z., Qu, P., Zhou, J., & Wang, W. (2015). Upregulation of microRNA-204 inhibits cell proliferation, migration and invasion in human renal cell carcinoma cells by downregulating SOX4. Molecular Medicine Reports, 12, 7059-7064. https://doi.org/10.3892/mmr.2015.4259
MLA
Wu, D., Pan, H., Zhou, Y., Zhang, Z., Qu, P., Zhou, J., Wang, W."Upregulation of microRNA-204 inhibits cell proliferation, migration and invasion in human renal cell carcinoma cells by downregulating SOX4". Molecular Medicine Reports 12.5 (2015): 7059-7064.
Chicago
Wu, D., Pan, H., Zhou, Y., Zhang, Z., Qu, P., Zhou, J., Wang, W."Upregulation of microRNA-204 inhibits cell proliferation, migration and invasion in human renal cell carcinoma cells by downregulating SOX4". Molecular Medicine Reports 12, no. 5 (2015): 7059-7064. https://doi.org/10.3892/mmr.2015.4259
Copy and paste a formatted citation
x
Spandidos Publications style
Wu D, Pan H, Zhou Y, Zhang Z, Qu P, Zhou J and Wang W: Upregulation of microRNA-204 inhibits cell proliferation, migration and invasion in human renal cell carcinoma cells by downregulating SOX4. Mol Med Rep 12: 7059-7064, 2015.
APA
Wu, D., Pan, H., Zhou, Y., Zhang, Z., Qu, P., Zhou, J., & Wang, W. (2015). Upregulation of microRNA-204 inhibits cell proliferation, migration and invasion in human renal cell carcinoma cells by downregulating SOX4. Molecular Medicine Reports, 12, 7059-7064. https://doi.org/10.3892/mmr.2015.4259
MLA
Wu, D., Pan, H., Zhou, Y., Zhang, Z., Qu, P., Zhou, J., Wang, W."Upregulation of microRNA-204 inhibits cell proliferation, migration and invasion in human renal cell carcinoma cells by downregulating SOX4". Molecular Medicine Reports 12.5 (2015): 7059-7064.
Chicago
Wu, D., Pan, H., Zhou, Y., Zhang, Z., Qu, P., Zhou, J., Wang, W."Upregulation of microRNA-204 inhibits cell proliferation, migration and invasion in human renal cell carcinoma cells by downregulating SOX4". Molecular Medicine Reports 12, no. 5 (2015): 7059-7064. https://doi.org/10.3892/mmr.2015.4259
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