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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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November-2015 Volume 12 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

miR‑34a inhibits colon cancer proliferation and metastasis by inhibiting platelet‑derived growth factor receptor α

  • Authors:
    • Chunyan Li
    • Yulin Wang
    • Shuming Lu
    • Zhuqing Zhang
    • Hua Meng
    • Lina Liang
    • Yan Zhang
    • Bo Song
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Pathology, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China, Department of Pathology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China
  • Pages: 7072-7078
    |
    Published online on: August 28, 2015
       https://doi.org/10.3892/mmr.2015.4263
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Abstract

The microRNA (miRNA), miR‑34a is significant in colon cancer progression. In the present study, the role of miR‑34a in colon cancer cell proliferation and metastasis was investigated. It was found that the expression of miR‑34a in colon cancer tissues and cell lines was lower when compared with that of normal tissues and cells. Further research demonstrated that miR‑34a inhibited cell proliferation, induced G1 phase arrest, and suppressed metastasis and epithelial mesenchymal transition in colon cancer cells. Bioinformatic prediction indicated that platelet‑derived growth factor receptor α (PDGFRA) was a potential target gene of miR‑34a and a luciferase assay identified that PDGFRA was a novel direct target gene of miR‑34a. In addition, assays of western blot analyses and quantitative reverse‑transcription polymerase chain reaction confirmed that miR‑34a decreased PDGFRA mRNA expression and protein levels in colon cancer cells. Assessment of cellular function indicated that miR‑34a inhibited colon cancer progression via PDGFRA. These findings demonstrate that miR‑34a may act as a negative regulator in colon cancer by targeting PDGFRA.
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Copy and paste a formatted citation
Spandidos Publications style
Li C, Wang Y, Lu S, Zhang Z, Meng H, Liang L, Zhang Y and Song B: miR‑34a inhibits colon cancer proliferation and metastasis by inhibiting platelet‑derived growth factor receptor α. Mol Med Rep 12: 7072-7078, 2015.
APA
Li, C., Wang, Y., Lu, S., Zhang, Z., Meng, H., Liang, L. ... Song, B. (2015). miR‑34a inhibits colon cancer proliferation and metastasis by inhibiting platelet‑derived growth factor receptor α. Molecular Medicine Reports, 12, 7072-7078. https://doi.org/10.3892/mmr.2015.4263
MLA
Li, C., Wang, Y., Lu, S., Zhang, Z., Meng, H., Liang, L., Zhang, Y., Song, B."miR‑34a inhibits colon cancer proliferation and metastasis by inhibiting platelet‑derived growth factor receptor α". Molecular Medicine Reports 12.5 (2015): 7072-7078.
Chicago
Li, C., Wang, Y., Lu, S., Zhang, Z., Meng, H., Liang, L., Zhang, Y., Song, B."miR‑34a inhibits colon cancer proliferation and metastasis by inhibiting platelet‑derived growth factor receptor α". Molecular Medicine Reports 12, no. 5 (2015): 7072-7078. https://doi.org/10.3892/mmr.2015.4263
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Wang Y, Lu S, Zhang Z, Meng H, Liang L, Zhang Y and Song B: miR‑34a inhibits colon cancer proliferation and metastasis by inhibiting platelet‑derived growth factor receptor α. Mol Med Rep 12: 7072-7078, 2015.
APA
Li, C., Wang, Y., Lu, S., Zhang, Z., Meng, H., Liang, L. ... Song, B. (2015). miR‑34a inhibits colon cancer proliferation and metastasis by inhibiting platelet‑derived growth factor receptor α. Molecular Medicine Reports, 12, 7072-7078. https://doi.org/10.3892/mmr.2015.4263
MLA
Li, C., Wang, Y., Lu, S., Zhang, Z., Meng, H., Liang, L., Zhang, Y., Song, B."miR‑34a inhibits colon cancer proliferation and metastasis by inhibiting platelet‑derived growth factor receptor α". Molecular Medicine Reports 12.5 (2015): 7072-7078.
Chicago
Li, C., Wang, Y., Lu, S., Zhang, Z., Meng, H., Liang, L., Zhang, Y., Song, B."miR‑34a inhibits colon cancer proliferation and metastasis by inhibiting platelet‑derived growth factor receptor α". Molecular Medicine Reports 12, no. 5 (2015): 7072-7078. https://doi.org/10.3892/mmr.2015.4263
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