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Decreased 13N‑labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy

  • Authors:
    • Tao Wang
    • Xuemei Wang
    • Yulin He
    • Tao Zhang
    • Jianqiang Song
    • Xia Bai
    • Chunlei Han
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, P.R. China, Department of Nuclear Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, P.R. China, Turku PET Center, Turku University Hospital, Turku 20520, Finland
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6598-6604
    |
    Published online on: September 9, 2015
       https://doi.org/10.3892/mmr.2015.4303
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Abstract

Carotid artery plaques are a leading cause of ischemic stroke, and carotid endarterectomy (CEA) is one of the major treatment approaches for this disease. Changes in cerebral metabolism following CEA remain unclear. The present study aimed to evaluate the effect of cerebral ammonia metabolism following CEA using 13N‑labeled ammonia positron emission tomography (PET) in humans. A total of 20 patients were enrolled in the present study, with a mean age of 59.5 years, comprising 16 males and four females. Of these patients, eight underwent right CEA and 12 underwent left CEA. The rate of carotid artery stenosis was between 50‑69% in six of the patients, between 70‑99% in 11 of the patients and was at 100% (thrombosis) in three of the patients, measured by computerised tomography digital subtraction angiography prior to CEA. 13N‑labeled ammonia (137 MBq) PET scanning was performed prior and subsequent to CEA surgery for each patient. The first ammonia PET scan was performed 1 day prior to CEA, while the second PET scan was performed 1‑4 weeks following CEA. Following injection of 13N‑labeled ammonia, static PET was acquired for 10 min. The region of interest (ROI), covering the major cerebral hemisphere, was selected and ammonia uptake in the ROI was determined in the ipsilateral and contralateral hemispheres. No hyperperfusion syndrome was observed in the patients subsequent to CEA. No significant change in cerebral hemisphere ammonia uptake was observed between the ipsilateral and contralateral hemispheres prior to (ratio =0.98; P>0.01) or following (ratio =1.09; P>0.01) CEA. Ammonia uptake in the ipsilateral and contralateral hemispheres was significantly reduced to 23.2 and 23.5%, respectively, following CEA. Using 13N‑labeled ammonia PET to evaluate cerebral ammonia metabolism following CEA in patients with severe carotid artery stenosis, the present study demonstrated that uptake of ammonia in the ipsilateral and contralateral hemispheres was significantly reduced.
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Copy and paste a formatted citation
Spandidos Publications style
Wang T, Wang X, He Y, Zhang T, Song J, Bai X and Han C: Decreased 13N‑labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy. Mol Med Rep 12: 6598-6604, 2015.
APA
Wang, T., Wang, X., He, Y., Zhang, T., Song, J., Bai, X., & Han, C. (2015). Decreased 13N‑labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy. Molecular Medicine Reports, 12, 6598-6604. https://doi.org/10.3892/mmr.2015.4303
MLA
Wang, T., Wang, X., He, Y., Zhang, T., Song, J., Bai, X., Han, C."Decreased 13N‑labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy". Molecular Medicine Reports 12.5 (2015): 6598-6604.
Chicago
Wang, T., Wang, X., He, Y., Zhang, T., Song, J., Bai, X., Han, C."Decreased 13N‑labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy". Molecular Medicine Reports 12, no. 5 (2015): 6598-6604. https://doi.org/10.3892/mmr.2015.4303
Copy and paste a formatted citation
x
Spandidos Publications style
Wang T, Wang X, He Y, Zhang T, Song J, Bai X and Han C: Decreased 13N‑labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy. Mol Med Rep 12: 6598-6604, 2015.
APA
Wang, T., Wang, X., He, Y., Zhang, T., Song, J., Bai, X., & Han, C. (2015). Decreased 13N‑labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy. Molecular Medicine Reports, 12, 6598-6604. https://doi.org/10.3892/mmr.2015.4303
MLA
Wang, T., Wang, X., He, Y., Zhang, T., Song, J., Bai, X., Han, C."Decreased 13N‑labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy". Molecular Medicine Reports 12.5 (2015): 6598-6604.
Chicago
Wang, T., Wang, X., He, Y., Zhang, T., Song, J., Bai, X., Han, C."Decreased 13N‑labeled ammonia uptake in the ipsilateral and contralateral hemispheres following carotid endarterectomy". Molecular Medicine Reports 12, no. 5 (2015): 6598-6604. https://doi.org/10.3892/mmr.2015.4303
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