Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2015 Volume 12 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2015 Volume 12 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Pitavastatin attenuates monocyte activation in response to orthopedic implant‑derived wear particles by suppressing the NF‑κB signaling pathway

  • Authors:
    • Zehua Zhang
    • Fei Dai
    • Peng Cheng
    • Fei Luo
    • Tianyong Hou
    • Qiang Zhou
    • Zhao Xie
    • Moyuan Deng
    • Jian‑Zhong Xu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China, National and Regional United Engineering Laboratory of Tissue Engineering, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China
  • Pages: 6932-6938
    |
    Published online on: September 9, 2015
       https://doi.org/10.3892/mmr.2015.4306
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Aseptic loosening secondary to particle‑induced periprosthetic osteolysis is considered to be the primary cause of long‑term implant failure in orthopedic surgery. Implant‑derived wear particles activate and recruit macrophages and osteoclasts, which cause a persistent inflammatory response with bone destruction that is followed by a loosening of the implant. Thus, strategies for inhibiting macrophage and osteoclast function may provide a therapeutic benefit for preventing aseptic loosening. The aim of the present study was to determine the effects of pitavastatin on the activation and cytokine response of polymethyl methacrylate (PMMA) particle‑induced monocytes. Peripheral blood monocytes were obtained and treated with PMMA and pitavastatin. ELISA demonstrated that pitavastatin inhibited mRNA and protein expression of interleukin (IL)‑1β, IL‑6 and tumor necrosis factor‑α. Western blot analysis and immunofluorescence staining demonstrated that pitavastatin downregulated inhibitor of κB phosphorylation and degradation, and nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB) p65 translocation. Together, these results indicate that pitavastatin may attenuate monocyte activation in response to orthopedic implant wear particles by suppression of the NF‑κB signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Snow R, Granata J, Ruhil AV, Vogel K, McShane M and Wasielewski R: Associations between preoperative physical therapy and post-acute care utilization patterns and cost in total joint replacement. J Bone Joint Surg Am. 96:e1652014. View Article : Google Scholar : PubMed/NCBI

2 

Gallo J, Goodman SB, Konttinen YT and Raska M: Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty. Innate Immun. 19:213–224. 2013. View Article : Google Scholar :

3 

Pearl JI, Ma T, Irani AR, Huang Z, Robinson WH, Smith RL and Goodman SB: Role of the Toll-like receptor pathway in the recognition of orthopedic implant wear-debris particles. Biomaterials. 32:5535–5542. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Holt G, Murnaghan C, Reilly J and Meek RM: The biology of aseptic osteolysis. Clin Orthop Relat Res. 460:240–252. 2007.PubMed/NCBI

5 

Masana L: Pitavastatin in cardiometabolic disease: Therapeutic profile. Cardiovasc Diabetol. 12(Suppl 1): S22013. View Article : Google Scholar : PubMed/NCBI

6 

Saito Y: Pitavastatin: An overview. Atheroscler Suppl. 12:271–276. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Wang J and Kitajima I: Pitavastatin inactivates NF-kappaB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells. Oncol Rep. 17:1149–1154. 2007.PubMed/NCBI

8 

Takano K, Yamamoto S, Tomita K, Takashina M, Yokoo H, Matsuda N, Takano Y and Hattori Y: Successful treatment of acute lung injury with pitavastatin in septic mice: Potential role of glucocorticoid receptor expression in alveolar macrophages. J Pharmacol Exp Ther. 336:381–390. 2011. View Article : Google Scholar

9 

Katsuki S, Matoba T, Nakashiro S, Sato K, Koga J, Nakano K, Nakano Y, Egusa S, Sunagawa K and Egashira K: Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes. Circulation. 129:896–906. 2014. View Article : Google Scholar

10 

Wan YD, Sun TW, Kan QC, Guan FX and Zhang SG: Effect of statin therapy on mortality from infection and sepsis: A meta-analysis of randomized and observational studies. Crit Care. 18:R712014. View Article : Google Scholar : PubMed/NCBI

11 

Clohisy JC, Frazier E, Hirayama T and Abu-Amer Y: RANKL is an essential cytokine mediator of polymethylmethacrylate particle-induced osteoclastogenesis. J Orthop Res. 21:202–212. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Clohisy JC, Teitelbaum S, Chen S, Erdmann JM and Abu-Amer Y: Tumor necrosis factor-alpha mediates polymethylmethacrylate particle-induced NF-kappaB activation in osteoclast precursor cells. J Orthop Res. 20:174–181. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Clohisy JC, Yamanaka Y, Faccio R and Abu-Amer Y: Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis. J Orthop Res. 24:1358–1365. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Peng Q, Liu H, Shi S and Li M: Lycium ruthenicum polysaccharide attenuates inflammation through inhibiting TLR4/NF-κB signaling pathway. Int J Biol Macromol. 67:330–335. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Li Q and Verma IM: NF-kappaB regulation in the immune system. Nat Rev Immunol. 2:725–734. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Grunfeld R, Aydogan U and Juliano P: Ankle arthritis: Review of diagnosis and operative management. Med Clin North Am. 98:267–289. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Gallo J, Goodman SB, Konttinen YT, Wimmer MA and Holinka M: Osteolysis around total knee arthroplasty: A review of pathogenetic mechanisms. Acta Biomater. 9:8046–8058. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Liu X, Qu X, Wu C, Zhai Z, Tian B, Li H, Ouyang Z, Xu X, Wang W, Fan Q, et al: The effect of enoxacin on osteoclastogenesis and reduction of titanium particle-induced osteolysis via suppression of JNK signaling pathway. Biomaterials. 35:5721–5730. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Sabokbar A, Fujikawa Y, Murray DW and Athanasou NA: Bisphosphonates in bone cement inhibit PMMA particle induced bone resorption. Ann Rheum Dis. 57:614–618. 1998. View Article : Google Scholar

20 

Lohmann CH, Dean DD, Küster G, Casasola D, Buchhorn GH, Fink U, Schwartz Z and Boyan BD: Ceramic and PMMA particles differentially affect osteoblast phenotype. Biomaterials. 23:1855–1863. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Ramachandran R, Goodman SB and Smith RL: The effects of titanium and polymethylmethacrylate particles on osteoblast phenotypic stability. J Biomed Mater Res A. 77:512–517. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Zambonin G, Colucci S, Cantatore F and Grano M: Response of human osteoblasts to polymethylmetacrylate in vitro. Calcif Tissue Int. 62:362–365. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Liu FX, Wu CL, Zhu ZA, Li MQ, Mao YQ, Liu M, Wang XQ, Yu DG and Tang TT: Calcineurin/NFAT pathway mediates wear particle-induced TNF-α release and osteoclastogenesis from mice bone marrow macrophages in vitro. Acta Pharmacol Sin. 34:1457–1466. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Crotti TN, Smith MD, Findlay DM, Zreiqat H, Ahern MJ, Weedon H, Hatzinikolous G, Capone M, Holding C and Haynes D: Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss: Expression of receptor activator NFkappaB, RANK ligand and osteoprotegerin. Biomaterials. 25:565–573. 2004. View Article : Google Scholar

25 

Jiang Y, Jia T, Gong W, Wooley PH and Yang SY: Effects of Ti, PMMA, UHMWPE and Co-Cr wear particles on differentiation and functions of bone marrow stromal cells. J Biomed Mater Res A. 101:2817–2825. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Fuller K, Murphy C, Kirstein B, Fox SW and Chambers TJ: TNFalpha potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL. Endocrinology. 143:1108–1118. 2002.PubMed/NCBI

27 

Guo H, Zhang J, Hao S and Jin Q: Adenovirus-mediated small interfering RNA targeting tumor necrosis factor-α inhibits titanium particle-induced osteoclastogenesis and bone resorption. Int J Mol Med. 32:296–306. 2013.PubMed/NCBI

28 

Quinn JM, Horwood NJ, Elliott J, Gillespie MT and Martin TJ: Fibroblastic stromal cells express receptor activator of NF-kappaB ligand and support osteoclast differentiation. J Bone Miner Res. 15:1459–1466. 2000. View Article : Google Scholar : PubMed/NCBI

29 

García-López S, Villanueva R and Meikle MC: Alterations in the synthesis of IL-1β, TNF-α, IL-6 and their downstream targets RANKL and OPG by mouse calvarial osteoblasts in vitro: Inhibition of bone resorption by cyclic mechanical strain. Front Endocrinol (Lausanne). 4:1602013.

30 

Simsa-Maziel S, Zaretsky J, Reich A, Koren Y, Shahar R and Monsonego-Ornan E: IL-1RI participates in normal growth plate development and bone modeling. Am J Physiol Endocrinol Metab. 305:E15–E21. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Uekawa K, Hasegawa Y, Ma M, Nakagawa T, Katayama T, Sueta D, Toyama K, Kataoka K, Koibuchi N, Kawano T, et al: Rosuvastatin ameliorates early brain injury after subarachnoid hemorrhage via suppression of superoxide formation and nuclear factor-kappaB activation in rats. J Stroke Cerebrovasc Dis. 23:1429–1439. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Moon GJ, Kim SJ, Cho YH, Ryoo S and Bang OY: Antioxidant effects of statins in patients with atherosclerotic cerebrovascular disease. J Clin Neurol. 10:140–147. 2014. View Article : Google Scholar : PubMed/NCBI

33 

McGuire TR, Kalil AC, Dobesh PP, Klepser DG and Olsen KM: Anti-inflammatory effects of rosuvastatin in healthy subjects: A prospective longitudinal study. Curr Pharm Des. 20:1156–1160. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Yamanaka Y, Karuppaiah K and Abu-Amer Y: Polyubiquitination events mediate polymethylmethacrylate (PMMA) particle activation of NF-kappaB pathway. J Biol Chem. 286:23735–23741. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Hayden MS and Ghosh S: NF-κB in immunobiology. Cell Res. 21:223–244. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Dai F, Cheng P, Luo F, Hou T, Zhou Q, Xie Z, Deng M and Xu JZ: Pitavastatin attenuates monocyte activation in response to orthopedic implant‑derived wear particles by suppressing the NF‑κB signaling pathway. Mol Med Rep 12: 6932-6938, 2015.
APA
Zhang, Z., Dai, F., Cheng, P., Luo, F., Hou, T., Zhou, Q. ... Xu, J. (2015). Pitavastatin attenuates monocyte activation in response to orthopedic implant‑derived wear particles by suppressing the NF‑κB signaling pathway. Molecular Medicine Reports, 12, 6932-6938. https://doi.org/10.3892/mmr.2015.4306
MLA
Zhang, Z., Dai, F., Cheng, P., Luo, F., Hou, T., Zhou, Q., Xie, Z., Deng, M., Xu, J."Pitavastatin attenuates monocyte activation in response to orthopedic implant‑derived wear particles by suppressing the NF‑κB signaling pathway". Molecular Medicine Reports 12.5 (2015): 6932-6938.
Chicago
Zhang, Z., Dai, F., Cheng, P., Luo, F., Hou, T., Zhou, Q., Xie, Z., Deng, M., Xu, J."Pitavastatin attenuates monocyte activation in response to orthopedic implant‑derived wear particles by suppressing the NF‑κB signaling pathway". Molecular Medicine Reports 12, no. 5 (2015): 6932-6938. https://doi.org/10.3892/mmr.2015.4306
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Dai F, Cheng P, Luo F, Hou T, Zhou Q, Xie Z, Deng M and Xu JZ: Pitavastatin attenuates monocyte activation in response to orthopedic implant‑derived wear particles by suppressing the NF‑κB signaling pathway. Mol Med Rep 12: 6932-6938, 2015.
APA
Zhang, Z., Dai, F., Cheng, P., Luo, F., Hou, T., Zhou, Q. ... Xu, J. (2015). Pitavastatin attenuates monocyte activation in response to orthopedic implant‑derived wear particles by suppressing the NF‑κB signaling pathway. Molecular Medicine Reports, 12, 6932-6938. https://doi.org/10.3892/mmr.2015.4306
MLA
Zhang, Z., Dai, F., Cheng, P., Luo, F., Hou, T., Zhou, Q., Xie, Z., Deng, M., Xu, J."Pitavastatin attenuates monocyte activation in response to orthopedic implant‑derived wear particles by suppressing the NF‑κB signaling pathway". Molecular Medicine Reports 12.5 (2015): 6932-6938.
Chicago
Zhang, Z., Dai, F., Cheng, P., Luo, F., Hou, T., Zhou, Q., Xie, Z., Deng, M., Xu, J."Pitavastatin attenuates monocyte activation in response to orthopedic implant‑derived wear particles by suppressing the NF‑κB signaling pathway". Molecular Medicine Reports 12, no. 5 (2015): 6932-6938. https://doi.org/10.3892/mmr.2015.4306
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team