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Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction

  • Authors:
    • Jun-Min Yu
    • Xiao-Bo Zhang
    • Wen Jiang
    • Hui-Dong Wang
    • Yi-Na Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gerontology, The Fourth Clinical Medical College, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Gerontology, The Second Clinical Medical College, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6718-6726
    |
    Published online on: September 9, 2015
       https://doi.org/10.3892/mmr.2015.4307
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Abstract

The aim of the present study was to evaluate the effect of astragalosides (ASTs) on angiogenesis, as well as the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) following myocardial infarction (MI). MI was induced in rats by ligation of the left coronary artery. Twenty‑four hours after surgery, the rats were divided into low‑dose, high‑dose, control and sham surgery groups (n=8 per group). The low‑ and high‑dose groups were treated with ASTs (2.5 and 10 mg/kg/day, respectively, via intraperitoneal injection), while, the control and sham surgery group rats received saline. Serum levels, and mRNA and protein expression levels of VEGF and bFGF, as well as the microvessel density (MVD) were determined four weeks post‑treatment. Twenty‑four hours post‑surgery, VEGF and bFGF serum levels were observed to be comparable between the groups; while at four weeks, the VEGF and bFGF levels were higher in the AST‑treated rats (P<0.01). Similarly, VEGF and bFGF mRNA and protein expression levels were higher following AST treatment (P<0.05). No difference in VEGF mRNA expression between the low‑ and high‑dose groups was noted, however, an increase in the bFGF expression levels was detected in the high‑dose group. Newly generated blood vessels were observed following MI, with a significant increase in MVD observed in the AST‑treated groups (P<0.05). AST promotes angiogenesis of the heart and increases VEGF and bFGF expression levels. Thus, it is hypothesized that increased VEGF and bFGF levels may contribute to the AST‑induced increase in angiogenesis in rat models of MI.
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Copy and paste a formatted citation
Spandidos Publications style
Yu J, Zhang X, Jiang W, Wang H and Zhang Y: Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction. Mol Med Rep 12: 6718-6726, 2015.
APA
Yu, J., Zhang, X., Jiang, W., Wang, H., & Zhang, Y. (2015). Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction. Molecular Medicine Reports, 12, 6718-6726. https://doi.org/10.3892/mmr.2015.4307
MLA
Yu, J., Zhang, X., Jiang, W., Wang, H., Zhang, Y."Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction". Molecular Medicine Reports 12.5 (2015): 6718-6726.
Chicago
Yu, J., Zhang, X., Jiang, W., Wang, H., Zhang, Y."Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction". Molecular Medicine Reports 12, no. 5 (2015): 6718-6726. https://doi.org/10.3892/mmr.2015.4307
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Zhang X, Jiang W, Wang H and Zhang Y: Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction. Mol Med Rep 12: 6718-6726, 2015.
APA
Yu, J., Zhang, X., Jiang, W., Wang, H., & Zhang, Y. (2015). Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction. Molecular Medicine Reports, 12, 6718-6726. https://doi.org/10.3892/mmr.2015.4307
MLA
Yu, J., Zhang, X., Jiang, W., Wang, H., Zhang, Y."Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction". Molecular Medicine Reports 12.5 (2015): 6718-6726.
Chicago
Yu, J., Zhang, X., Jiang, W., Wang, H., Zhang, Y."Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction". Molecular Medicine Reports 12, no. 5 (2015): 6718-6726. https://doi.org/10.3892/mmr.2015.4307
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