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Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review)

  • Authors:
    • Xiuting He
    • Jie Li
    • Jing Wu
    • Manli Zhang
    • Pujun Gao
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Gastroenterology, The Second Branch of The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6405-6414
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    Published online on: September 10, 2015
       https://doi.org/10.3892/mmr.2015.4312
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Abstract

The hepatitis B virus (HBV) infection is a major risk factor in the development of chronic hepatitis (CH) and hepatocellular carcinoma (HCC). The activation‑induced cytidine deaminase (AID)/apolipoprotein B mRNA editing enzyme, catalytic polypeptide‑like (APOBEC) family of cytidine deaminases is significant in innate immunity, as it restricts numerous viruses, including HBV, through hypermutation‑dependent and ‑independent mechanisms. It is important to induce covalently closed circular (ccc)DNA degradation by interferon‑α without causing side effects in the infected host cell. Furthermore, organisms possess multiple mechanisms to regulate the expression of AID/APOBECs, control their enzymatic activity and restrict their access to DNA or RNA substrates. Therefore, the AID/APOBECs present promising targets for preventing and treating viral infections. In addition, gene polymorphisms of the AID/APOBEC family may alter host susceptibility to HBV acquisition and CH disease progression. Through G‑to‑A hypermutation, AID/APOBECs also edit HBV DNA and facilitate the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. The AID/APOBEC family and their associated editing patterns may also exert oncogenic activity. Understanding the effects of cytidine deaminases in CH virus-induced hepatocarcinogenesis may aid with developing efficient prophylactic and therapeutic strategies against HCC.
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Copy and paste a formatted citation
Spandidos Publications style
He X, Li J, Wu J, Zhang M and Gao P: Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review). Mol Med Rep 12: 6405-6414, 2015.
APA
He, X., Li, J., Wu, J., Zhang, M., & Gao, P. (2015). Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review). Molecular Medicine Reports, 12, 6405-6414. https://doi.org/10.3892/mmr.2015.4312
MLA
He, X., Li, J., Wu, J., Zhang, M., Gao, P."Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review)". Molecular Medicine Reports 12.5 (2015): 6405-6414.
Chicago
He, X., Li, J., Wu, J., Zhang, M., Gao, P."Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review)". Molecular Medicine Reports 12, no. 5 (2015): 6405-6414. https://doi.org/10.3892/mmr.2015.4312
Copy and paste a formatted citation
x
Spandidos Publications style
He X, Li J, Wu J, Zhang M and Gao P: Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review). Mol Med Rep 12: 6405-6414, 2015.
APA
He, X., Li, J., Wu, J., Zhang, M., & Gao, P. (2015). Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review). Molecular Medicine Reports, 12, 6405-6414. https://doi.org/10.3892/mmr.2015.4312
MLA
He, X., Li, J., Wu, J., Zhang, M., Gao, P."Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review)". Molecular Medicine Reports 12.5 (2015): 6405-6414.
Chicago
He, X., Li, J., Wu, J., Zhang, M., Gao, P."Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review)". Molecular Medicine Reports 12, no. 5 (2015): 6405-6414. https://doi.org/10.3892/mmr.2015.4312
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