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Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma

  • Authors:
    • Xiao Chun Hong
    • Yuan Jian Fen
    • Guo Chun Yan
    • Hong Hong
    • Cao Hong Yan
    • Li Wei Bing
    • Yu Hai Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Nantong Cancer Hospital, Nantong, Jiangsu 226001, P.R. China, Department of Clinical Laboratory, Traditional Chinese Medicine Hospital, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Hong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6445-6450
    |
    Published online on: September 14, 2015
       https://doi.org/10.3892/mmr.2015.4326
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Abstract

Epithelial membrane protein 3 (EMP3) is a transmembrane signaling molecule, which is important in the regulation of apoptosis, differentiation and invasion of cancer cells. However, the specific function and regulatory mechanism of EMP3 in primary breast carcinoma remain to be elucidated. In the present study, the mRNA and protein levels of EMP3 were observed to be upregulated in primary breast carcinoma tissues, compared with normal tissues. It was hypothesized that the overexpression of EMP3 was correlated with the downregulation of microRNA‑765 (miR‑765), an underexpressed miRNA in primary breast carcinoma tissues. Functional analysis demonstrated that EMP3 was regulated by miR‑765 through binding to its 3'untranslated region. In addition, the knockdown of EMP3 and miR‑765 had similar effects on the inhibition of proliferation and invasion in SK‑BR‑3 cells. These results provided novel insight into the regulatory mechanism of EMP3 in primary breast carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Hong XC, Fen YJ, Yan GC, Hong H, Yan CH, Bing LW and Zhong YH: Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. Mol Med Rep 12: 6445-6450, 2015.
APA
Hong, X.C., Fen, Y.J., Yan, G.C., Hong, H., Yan, C.H., Bing, L.W., & Zhong, Y.H. (2015). Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. Molecular Medicine Reports, 12, 6445-6450. https://doi.org/10.3892/mmr.2015.4326
MLA
Hong, X. C., Fen, Y. J., Yan, G. C., Hong, H., Yan, C. H., Bing, L. W., Zhong, Y. H."Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma". Molecular Medicine Reports 12.5 (2015): 6445-6450.
Chicago
Hong, X. C., Fen, Y. J., Yan, G. C., Hong, H., Yan, C. H., Bing, L. W., Zhong, Y. H."Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma". Molecular Medicine Reports 12, no. 5 (2015): 6445-6450. https://doi.org/10.3892/mmr.2015.4326
Copy and paste a formatted citation
x
Spandidos Publications style
Hong XC, Fen YJ, Yan GC, Hong H, Yan CH, Bing LW and Zhong YH: Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. Mol Med Rep 12: 6445-6450, 2015.
APA
Hong, X.C., Fen, Y.J., Yan, G.C., Hong, H., Yan, C.H., Bing, L.W., & Zhong, Y.H. (2015). Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. Molecular Medicine Reports, 12, 6445-6450. https://doi.org/10.3892/mmr.2015.4326
MLA
Hong, X. C., Fen, Y. J., Yan, G. C., Hong, H., Yan, C. H., Bing, L. W., Zhong, Y. H."Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma". Molecular Medicine Reports 12.5 (2015): 6445-6450.
Chicago
Hong, X. C., Fen, Y. J., Yan, G. C., Hong, H., Yan, C. H., Bing, L. W., Zhong, Y. H."Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma". Molecular Medicine Reports 12, no. 5 (2015): 6445-6450. https://doi.org/10.3892/mmr.2015.4326
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