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Article

Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne

  • Authors:
    • Chang‑Seob Seo
    • Hye‑Sun Lim
    • Soo‑Jin Jeong
    • Hyeun‑Kyoo Shin
  • View Affiliations / Copyright

    Affiliations: K-herb Research Center, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea
  • Pages: 7789-7795
    |
    Published online on: September 21, 2015
       https://doi.org/10.3892/mmr.2015.4342
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Abstract

Aucklandia lappa Decne, a well-known traditional herbal medicine, is used for the treatment of asthma, rheumatism, coughs, tuberculosis and numerous other diseases. The present study evaluated the inhibitory effects of the three sesquiterpene lactones costunolide, dehydrocostus lactone, and alantolactone, isolated from a 70% methanolic extract of Aucklandia lappa, on the expression of chemokine mRNA in HaCaT human keratinocyte cells. The cytotoxicities of the compounds on HaCaT cells were evaluated using a Cell Counting Kit8 assay. Furthermore, the inhibitory effects of the three compounds on chemokine expression in tumor necrosis factor (TNF)‑α‑ and interferon (IFN)‑γ‑stimulated HaCaT cells were analyzed by reverse transcription-polymerase chain reaction analysis. Treatment with the compounds caused a significant reduction in the mRNA expression of a range of chemokines, including TARC/CCL17, MDC/CCL22, RANTES/CCL5 and interleukin‑8 in TNF-α and IFN-γ-stimulated HaCaT cells. The present study indicated that costunolide, dehydrocostus lactone and alantolactone may have the potential to be used for treating inflammatory skin disorders by suppressing chemokine expression.
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Copy and paste a formatted citation
Spandidos Publications style
Seo CS, Lim HS, Jeong SJ and Shin HK: Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne. Mol Med Rep 12: 7789-7795, 2015.
APA
Seo, C., Lim, H., Jeong, S., & Shin, H. (2015). Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne. Molecular Medicine Reports, 12, 7789-7795. https://doi.org/10.3892/mmr.2015.4342
MLA
Seo, C., Lim, H., Jeong, S., Shin, H."Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne". Molecular Medicine Reports 12.5 (2015): 7789-7795.
Chicago
Seo, C., Lim, H., Jeong, S., Shin, H."Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne". Molecular Medicine Reports 12, no. 5 (2015): 7789-7795. https://doi.org/10.3892/mmr.2015.4342
Copy and paste a formatted citation
x
Spandidos Publications style
Seo CS, Lim HS, Jeong SJ and Shin HK: Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne. Mol Med Rep 12: 7789-7795, 2015.
APA
Seo, C., Lim, H., Jeong, S., & Shin, H. (2015). Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne. Molecular Medicine Reports, 12, 7789-7795. https://doi.org/10.3892/mmr.2015.4342
MLA
Seo, C., Lim, H., Jeong, S., Shin, H."Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne". Molecular Medicine Reports 12.5 (2015): 7789-7795.
Chicago
Seo, C., Lim, H., Jeong, S., Shin, H."Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne". Molecular Medicine Reports 12, no. 5 (2015): 7789-7795. https://doi.org/10.3892/mmr.2015.4342
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