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Gene microarray analyses for potential biomarkers of single and recurrent venous thromboembolism

  • Authors:
    • Wugang Zhou
    • Ke Zhang
    • Dongrui Chen
    • Pingjin Gao
    • Qiao Wang
  • View Affiliations / Copyright

    Affiliations: Emergency Department, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China, Department of Hypertension, Ruijin Hospital, Shanghai Key Lab of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7358-7366
    |
    Published online on: September 22, 2015
       https://doi.org/10.3892/mmr.2015.4349
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Abstract

Venous thromboembolism is a major cause of morbidity and mortality with a high recurrence rate. The present study aimed to explore the molecular mechanisms and potential biomarkers of single venous thromboembolism (SVTE) and recurrent venous thromboembolism (RVTE). The microarray dataset GSE19151 was downloaded from Gene Expression Omnibus, which contained data from whole blood samples from 63 healthy controls, 32 SVTE and 38 RVTE patients. Differentially expressed genes (DEGs) in the SVTE and RVTE groups compared with those in the controls were identified using the t‑test, followed by clustering analysis of DEGs and samples. Functional and pathway enrichment analyses were performed for DEGs in patients with RVTE and SVTE, as well as specific DEGs in patients with RVTE. The identified 42 DEGs in RVTE were mainly enriched in biological processes of cellular protein metabolism, gene expression and translational elongation as well as in pathways associated with ribosomes, Parkinson's disease and oxidative phosphorylation. In SVTE, 20 DEGs were identified, which were mainly involved in biological processes of biopolymer biosynthesis, translational elongation and cellular protein metabolism as well as pathways associated with ribosomes and cardiac muscle contraction. In RVTE, 22 specific DEGs were mainly involved in translational elongation, negative regulation of the force of heart contraction by chemical signals, cell proliferation, ribosomal pathways and protein export. The identified DEGs of SVTE, including COX7C and UQCRQ, may be potential biomarkers for SVTE, and the specific DEGs of RVTE, including ADRBK1, NDUFA5 and ATP5O, may be potential biomarkers for RVTE.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou W, Zhang K, Chen D, Gao P and Wang Q: Gene microarray analyses for potential biomarkers of single and recurrent venous thromboembolism. Mol Med Rep 12: 7358-7366, 2015.
APA
Zhou, W., Zhang, K., Chen, D., Gao, P., & Wang, Q. (2015). Gene microarray analyses for potential biomarkers of single and recurrent venous thromboembolism. Molecular Medicine Reports, 12, 7358-7366. https://doi.org/10.3892/mmr.2015.4349
MLA
Zhou, W., Zhang, K., Chen, D., Gao, P., Wang, Q."Gene microarray analyses for potential biomarkers of single and recurrent venous thromboembolism". Molecular Medicine Reports 12.5 (2015): 7358-7366.
Chicago
Zhou, W., Zhang, K., Chen, D., Gao, P., Wang, Q."Gene microarray analyses for potential biomarkers of single and recurrent venous thromboembolism". Molecular Medicine Reports 12, no. 5 (2015): 7358-7366. https://doi.org/10.3892/mmr.2015.4349
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou W, Zhang K, Chen D, Gao P and Wang Q: Gene microarray analyses for potential biomarkers of single and recurrent venous thromboembolism. Mol Med Rep 12: 7358-7366, 2015.
APA
Zhou, W., Zhang, K., Chen, D., Gao, P., & Wang, Q. (2015). Gene microarray analyses for potential biomarkers of single and recurrent venous thromboembolism. Molecular Medicine Reports, 12, 7358-7366. https://doi.org/10.3892/mmr.2015.4349
MLA
Zhou, W., Zhang, K., Chen, D., Gao, P., Wang, Q."Gene microarray analyses for potential biomarkers of single and recurrent venous thromboembolism". Molecular Medicine Reports 12.5 (2015): 7358-7366.
Chicago
Zhou, W., Zhang, K., Chen, D., Gao, P., Wang, Q."Gene microarray analyses for potential biomarkers of single and recurrent venous thromboembolism". Molecular Medicine Reports 12, no. 5 (2015): 7358-7366. https://doi.org/10.3892/mmr.2015.4349
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